2-(3-氟苯基)-组胺 | 133118-41-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-(3-氟苯基)-组胺
• 英文名称: 2-(3-fluorophenyl)-histamine
• 英文别名: 2-<2-(3-fluorophenyl)-4-imidazolyl>ethanamine；2-(3-fluorophenyl)histamine；2-[2-(3-fluorophenyl)-1H-imidazol-5-yl]ethanamine
• CAS: 133118-41-9
• 化学式: C₁₁H₁₂FN₃
• 分子量: 205.235
• InChiKey: LRDYABKFMHSIPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-acetoxy-4N-phthalimidobutan-2-one 、 3-fluorobenzenecarboximidic acid methyl ester hydrochloride 生成 2-(3-氟苯基)-组胺
  参考文献：
  名称：

  Histamine analogues. 33rd communication: 2-phenylhistamines with high histamine H1-agonistic activity

  摘要：

  DOI：

  10.1016/0223-5234(90)90132-m

文献信息

• Analgesic compositions comprising an antihistamine
  申请人：Charleston Laboratories, Inc.

  公开号：EP2813144A1

  公开（公告）日：2014-12-17

  Pharmaceutical compositions are provided which comprise effective amounts of analgesic to treat a subject, including to reduce or eliminate an adverse effect associated with the analgesic.

  提供的药物组合物包含有效量的镇痛剂，用于治疗受试者，包括减少或消除与镇痛剂相关的不良反应。
• PHARMACEUTICAL COMPOSITIONS FOR TREATING HEADACHE AND ELIMINATING NAUSEA
  申请人：Charleston Laboratories, Inc.

  公开号：EP3090743A1

  公开（公告）日：2016-11-09

  Methods and compositions are provided which comprise effective amounts of analgesic to treat a subject, including reducing or eliminating an adverse effect associated with the analgesic.

  提供的方法和组合物包含有效量的镇痛剂，用于治疗受试者，包括减少或消除与镇痛剂相关的不良反应。
• Pharmaceutical compositions for treating or preventing pain
  申请人：LOCL PHARMA, INC.

  公开号：US10016368B2

  公开（公告）日：2018-07-10

  Methods and compositions are provided which comprise effective amounts of one or more analgesics, such as hydrocodone or acetaminophen, and an antiemetic, such as promethazine, to treat or prevent pain in a subject, and to reduce or prevent an adverse effect associated with the analgesics.

  所提供的方法和组合物包含有效量的一种或多种镇痛剂（如氢可酮或对乙酰氨基酚）和止吐剂（如异丙嗪），用于治疗或预防受试者的疼痛，并减少或预防与镇痛剂相关的不良反应。
• Pharmaceutical compositions
  申请人：LOCL PHARMA, INC.

  公开号：US10064856B2

  公开（公告）日：2018-09-04

  Methods and compositions are provided which comprise effective amounts of an analgesic to treat a subject, including reducing or eliminating an adverse effect associated with the analgesic.

  提供的方法和组合物包含有效量的镇痛剂，用于治疗受试者，包括减少或消除与镇痛剂相关的不良反应。
• Pharmaceutical compositions comprising 5HT receptor agonist and antiemetic particulates
  申请人：CHARLESTON LABORATORIES, INC.

  公开号：US10179109B2

  公开（公告）日：2019-01-15

  Pharmaceutical compositions and methods are provided to treat headache, headache-associated symptoms, photophobia, or adverse effects associated with the headache. Also provided herein are small smooth particulates comprising a 5HT1B/1D receptor agonist. Compositions for oral administration are described herein wherein the compositions comprise a combination of active agents, such as a 5HT1B/1D receptor agonist and one or more antiemetics.

  提供了治疗头痛、头痛相关症状、畏光或头痛相关不良反应的药物组合物和方法。本文还提供了包含 5HT1B/1D 受体激动剂的小光滑微粒。本文描述了用于口服给药的组合物，其中组合物包含活性剂的组合，如5HT1B/1D受体激动剂和一种或多种止吐药。