D-cymarose | 579-04-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-cymarose
• 英文别名: cymarose；β-D-cymarose；beta-D-Cymarose pyranose；(2R,4S,5R,6R)-4-methoxy-6-methyloxane-2,5-diol
• CAS: 579-04-4；89253-99-6
• 化学式: C₇H₁₄O₄
• 分子量: 162.186
• InChiKey: DBDJCJKVEBFXHG-XZBKPIIZSA-N

物化性质

• 熔点：
  93-94°
• 比旋光度：
  D20 +54.7° (c = 3.2 in water after 24 hrs)
• 沸点：
  208.87°C (rough estimate)
• 密度：
  1.0585 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  雌-4-烯-3-酮,10-乙基-17-羟基-,(17b)-(9CI) 、 D-cymarose 、 氯化亚锡 、 三乙胺 在 silver trifluoromethanesulfonate 二氯甲烷 、 Thevetose cymarose 、 silica gel 、 ethyl acetate n-hexane 作用下， 以 二氯甲烷 为溶剂， 反应 17.0h， 生成 Thevetose cymarose
  参考文献：
  名称：

  Pharmaceutical compositions having appetite suppressant activity

  摘要：

  一种药物组合物，其中包含可从Trichocaulon属或Hoodia属植物中提取的提取物，该提取物含有具有公式（1）的食欲抑制剂。还提供了获得提取物的方法以及合成化合物（1）及其类似物和衍生物的方法。本发明还扩展了使用这种提取物和化合物（1）及其类似物制造具有食欲抑制活性的药物。本发明还提供了合成化合物（1）的新型中间体。

  公开号：

  US06376657B1
• 作为产物：
  描述：

  caudatin-3-O-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside 在 硫酸 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 D-cymarose
  参考文献：
  名称：

  Antiepileptic C₂₁steroids from the roots ofCynanchum otophyllum

  摘要：

  In order to discover more natural products possessing potentially antiepileptic activities, three C-21 steroids, including a new one, characterized as caudatin-3-O--d-cymaropyranosyl-(14)--d-cymaropyranosyl-(14)--d-cymaropyranoside (1), and two known analogs, otophylloside B (2) and caudatin-3-O--d-oleandropyranosyl-(14)--d-oleandropyranosyl-(14)--d-cymaropyranosyl-(14)--d-cymaropyranoside (3), were isolated from the chloroform extract of the roots of Cynanchum otophyllum and evaluated for their antiepileptic activities by pentylenetrazole (PTZ)-induced zebrafish larval locomotor assay. The results showed that all of them had marked activities of suppressing PTZ-induced seizure behaviors in larval zebrafish at the dose of 10g/ml.

  DOI：

  10.1080/10286020.2014.1001380

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS<br/>[FR] COMPOSÉS ET MÉTHODES POUR LE TRAITEMENT D'INFECTIONS BACTÉRIENNES
  申请人：CIDARA THERAPEUTICS INC

  公开号：WO2018006063A1

  公开（公告）日：2018-01-04

  Compositions and methods for the treatment of bacterial infections include compounds containing dimers of cyclic heptapeptides conjugated to one or more monosaccharide or oligosaccharide moieties. In particular, compounds can be used in the treatment of bacterial infections caused by Gram-negative bacteria.

  用于治疗细菌感染的组合物和方法包括含有环七肽二聚体与一个或多个单糖或寡糖基团结合的化合物。特别是，这些化合物可用于治疗由革兰氏阴性细菌引起的细菌感染。
• CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：US20160051691A1

  公开（公告）日：2016-02-25

  The present invention provides iRNA agents comprising at least one subunit of the formula (I): wherein: A and B are each independently for each occurrence O, N(R N ) or S; X and Y are each independently for each occurrence H, OH, a hydroxyl protecting group, a phosphate group, a phosphodiester group, an activated phosphate group, an activated phosphite group, a phosphoramidite, a solid support, —P(Z′)(Z″)O-nucleoside, —P(Z′)(Z″)O-oligonucleotide, a lipid, a PEG, a steroid, a lipophile, a polymer, —P(Z′)(Z″)O-Linker-OP(Z′″)(Z″″)O-oligonucleotide, a nucleotide, an oligonucleotide, —P(Z′)(Z″)-formula(I), —P(Z′)(Z″)— or -Linker-R; R is L G , -Linker-L G , or has the structure shown below: L G is independently for each occurrence a carbohydrate, e.g., monosaccharide, disaccharide, trisaccharide, tetrasaccharide, oligosaccharide, polysaccharide; R N is independently for each occurrence H, methyl, ethyl, propyl, isopropyl, butyl, or benzyl; and Z′, Z″, Z′″ and Z″″ are each independently for each occurrence O or S.

  本发明提供了包含至少一个式(I)的亚单位的iRNA试剂： 其中： A和B分别独立于每次出现O、N(RN)或S； X和Y分别独立于每次出现H、OH、一个羟基保护基团、一个磷酸基团、一个磷酸二酯基团、一个活化磷酸基团、一个活化亚磷酸基团、一个磷酰胺基团、一个固相支持、-P(Z')(Z″)O-核苷、-P(Z')(Z″)O-寡核苷酸、一个脂质、一个PEG、一个类固醇、一个亲脂物质、一个聚合物、-P(Z')(Z″)O-连接子-OP(Z′″)(Z″″)O-寡核苷酸、一个核苷酸、一个寡核苷酸、-P(Z')(Z″)-式(I)、-P(Z')(Z″)-或-连接子-R； R是LG、-连接子-LG，或具有下面所示结构： LG独立于每次出现的是一种碳水化合物，例如，单糖、双糖、三糖、四糖、寡糖、多糖； RN独立于每次出现的是H、甲基、乙基、丙基、异丙基、丁基或苄基； Z'、Z″、Z′″和Z″″分别独立于每次出现的是O或S。
• [EN] POLYNUCLEOTIDE CONSTRUCTS HAVING DISULFIDE GROUPS<br/>[FR] CONSTRUCTIONS POLYNUCLÉOTIDIQUES CONTENANT DES GROUPES DISULFURE
  申请人：SOLSTICE BIOLOG LTD

  公开号：WO2015069932A1

  公开（公告）日：2015-05-14

  The invention features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components is attached to an internudeotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains one or more bulky groups proximal to the disulfide group. The invention also features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components (i) is attached to an internudeotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains at least 4 atoms in a chain between the disulfide linkage and the phosphorus atom of the internudeotide bridging group or the terminal group; and where the chain does not contain a phosphate, an amide, an ester, or an alkenylene. The invention also features methods of delivering a polynucleotide to a cell using the polynucleotide constructs of the invention.

  该发明涉及包含一个或多个组分（i）的聚核苷酸构造，其中每个一个或多个组分连接到聚核苷酸构造的一个核苷酸桥连基团或末端基团上，每个一个或多个组分（i）包含靠近二硫键的一个或多个臃肿基团。该发明还涉及包含一个或多个组分（i）的聚核苷酸构造，其中每个一个或多个组分（i）连接到聚核苷酸构造的一个核苷酸桥连基团或末端基团上，每个一个或多个组分（i）在二硫键和核苷酸桥连基团或末端基团的磷原子之间的链中至少包含4个原子；并且该链不包含磷酸酯、酰胺、酯或烯基烃。该发明还涉及使用该发明的聚核苷酸构造将聚核苷酸传递到细胞的方法。
• Steroidal Glycosides from Roots of Cynanchum otophyllum
  作者：Xin-Xin Yang、Yong-Rui Bao、Shuai Wang、Rui-Qing Zhu、Li-Na Bao、Yu-Peng Guan、Xian-Sheng Meng

  DOI：10.1007/s10600-015-1388-3

  日期：2015.7

  Four steroids were isolated from the ethyl acetate extract of the roots of Cynanchum otophyllum. Their structures were identified as qinyangshengenin-3-O-β-D-oleandropyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside (1), gagamine (2), otophylloside B (3), and caudatin (4). Compound 1 is a new steroidal glycoside, and the structures of these compounds were established on the basis of chemical and spectroscopic methods.

  从牛皮消（Cynanchum otophyllum）根部的乙酸乙酯提取物中分离得到4个甾体化合物，其结构被鉴定为：青阳参苷（qinyangshengenin-3-O-β-D-oleandropyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside，1）、加加明（gagamine，2）、牛皮消苷B（otophylloside B，3）和牛皮消苷元（caudatin，4）。化合物1是一种新的甾体糖苷，这些化合物的结构是通过化学和光谱方法确定的。
• Three New Steroidal Glycosides from the Roots of Cynanchum auriculatum
  作者：Yu Lu、Hong-Li Teng、Guang-Zhong Yang、Zhi-Nan Mei

  DOI：10.3390/molecules16021901

  日期：——

  Three new steroidal glycosides, cyanoauriculosides F, G and H (1-3), were isolated from the roots of Cynanchum auriculatum (Asclepiadaceae) along with two known steroidal derivatives. On the basis of spectroscopic analysis and chemical methods, their structures were identified as 20-O-acetyl-8,14-seco-penupogenin-8-one 3-O-α-L-cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-diginopyranosyl-(1→

  三种新的甾体糖苷，氰基木糖甙 F、G 和 H (1-3)，与两种已知的甾体衍生物一起从金合欢 (Asclepiadaceae) 的根中分离出来。经光谱分析和化学方法鉴定，其结构为20-O-acetyl-8,14-seco-penupogenin-8-one 3-O-α-L-cymaropyranosyl-(1→4)-β- D-cymaropyranosyl-(1→4)-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside (1), 2',3'-Z-gagaminine 3-O-α-L-cymaropyranosyl- (1→4)-β-D-cymaro-pyranosyl-(1→4)-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside (2), 17-O-acetyl-kidjoranin 3- O-α-L-c