{[Bis-(2-methoxy-ethyl)-carbamoyl]-methoxy}-acetic acid | 215101-73-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: {[Bis-(2-methoxy-ethyl)-carbamoyl]-methoxy}-acetic acid
• 英文别名: Acetic acid, [2-[bis(2-methoxyethyl)amino]-2-oxoethoxy]-；2-[2-[bis(2-methoxyethyl)amino]-2-oxoethoxy]acetic acid
• CAS: 215101-73-8
• 化学式: C₁₀H₁₉NO₆
• mdl: MFCD13198472
• 分子量: 249.264
• InChiKey: RQHSQLIUQUOKOM-UHFFFAOYSA-N

物化性质

• 沸点：
  419.9±45.0 °C(Predicted)
• 密度：
  1.177±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  17
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  85.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  {[Bis-(2-methoxy-ethyl)-carbamoyl]-methoxy}-acetic acid 、 N-[n'-Fmoc-(2'-氨基乙基)]甘氨酸 在 N-甲基吗啉 、 三甲基乙酰氯 、 碳酸氢钠 、 potassium carbonate 作用下， 以 水 、 丙酮 、 乙腈 为溶剂， 反应 0.5h， 以78%的产率得到2-[[2-[2-[bis(2-methoxyethyl)amino]-2-oxoethoxy]acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]acetic acid
  参考文献：
  名称：

  PNA solubility enhancers

  摘要：

  Fmoc-protected hydrophilic amino acids were prepared and incorporated into peptide nucleic acid (FNA). N- and C-terminal modification of FNA did not affect its ability to hybridize to complementary nucleic acid targets as determined by dot blot, PNA-FISH and Tm experiments. The compounds allowed us to prepare several probes which were previously impossible to make, purify or use due to limited aqueous solubility or self-aggregation. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01581-0
• 作为产物：
  描述：

  二甘醇酐 、 双(2-甲氧基乙基)胺 以 二氯甲烷 为溶剂， 反应 2.0h， 以59%的产率得到{[Bis-(2-methoxy-ethyl)-carbamoyl]-methoxy}-acetic acid
  参考文献：
  名称：

  PNA solubility enhancers

  摘要：

  Fmoc-protected hydrophilic amino acids were prepared and incorporated into peptide nucleic acid (FNA). N- and C-terminal modification of FNA did not affect its ability to hybridize to complementary nucleic acid targets as determined by dot blot, PNA-FISH and Tm experiments. The compounds allowed us to prepare several probes which were previously impossible to make, purify or use due to limited aqueous solubility or self-aggregation. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01581-0

文献信息

• PNA solubility enhancers
  作者：Brian D. Gildea、Shelagh Casey、Joan MacNeill、Heather Perry-O'Keefe、Ditte Sørensen、James M. Coull

  DOI：10.1016/s0040-4039(98)01581-0

  日期：1998.10

  Fmoc-protected hydrophilic amino acids were prepared and incorporated into peptide nucleic acid (FNA). N- and C-terminal modification of FNA did not affect its ability to hybridize to complementary nucleic acid targets as determined by dot blot, PNA-FISH and Tm experiments. The compounds allowed us to prepare several probes which were previously impossible to make, purify or use due to limited aqueous solubility or self-aggregation. (C) 1998 Elsevier Science Ltd. All rights reserved.