7-ethyl-N,N-dimethyltryptamine | 74798-67-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 7-ethyl-N,N-dimethyltryptamine
• 英文别名: 2-(7-ethyl-1H-indol-3-yl)-N,N-dimethylethanamine
• CAS: 74798-67-7
• 化学式: C₁₄H₂₀N₂
• 分子量: 216.326
• InChiKey: DNEWEHQANHHHCZ-UHFFFAOYSA-N

物化性质

• 熔点：
  58-62 °C
• 沸点：
  90-95 °C(Press: 0.2 Torr)
• 密度：
  1.041±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  19
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-乙基苯胺 在 盐酸 、 sodium tetrahydroborate 、 lithium aluminium tetrahydride 、 三氯化铝 、 三氯化硼 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醚 、 水 为溶剂， 反应 41.25h， 生成 7-ethyl-N,N-dimethyltryptamine
  参考文献：
  名称：

  Studies on several 7-substituted N,N-dimethyltryptamines

  摘要：

  Several 7-substituted derivatives of N,N-dimethyltryptamine (DMT) were prepared and evaluated in the rat fundus serotonin receptor assay and in a behavioral (discriminative stimulus) assay in rats. Both 7-Me- and 5-OMe-7-Me-DMT possess a higher pA2, and 5,7-(OMe)2-DMT a lower pA2, than that of DMT itself. Like DMT, all three of these compounds produce behavioral effects in rats which are similar to those of the hallucinogen 5-OMe-DMT. Although 7-ET- and 7-Br-DMT possess a higher serotonin receptor affinity than DMT, neither produce behavioral effects which parallel those of 5-OMe-DMT. In contrast, 6-Me-DMT and its 5-OMe derivative do not interact with the serotonin receptors in a competitive manner and are inactive in the discriminative stimulus assay.

  DOI：

  10.1021/jm00185a014

文献信息

• GLENNON R. A.; SCHUBERT E.; JACYNO J. M.; ROSECRANS J. A., J. MED. CHEM., 1980, 23, NO 11, 1222-1226
  作者：GLENNON R. A.、 SCHUBERT E.、 JACYNO J. M.、 ROSECRANS J. A.

  DOI：——

  日期：——
• Studies on several 7-substituted N,N-dimethyltryptamines
  作者：R. A. Glennon、E. Schubert、J. M. Jacyno、J. A. Rosecrans

  DOI：10.1021/jm00185a014

  日期：1980.11

  Several 7-substituted derivatives of N,N-dimethyltryptamine (DMT) were prepared and evaluated in the rat fundus serotonin receptor assay and in a behavioral (discriminative stimulus) assay in rats. Both 7-Me- and 5-OMe-7-Me-DMT possess a higher pA2, and 5,7-(OMe)2-DMT a lower pA2, than that of DMT itself. Like DMT, all three of these compounds produce behavioral effects in rats which are similar to those of the hallucinogen 5-OMe-DMT. Although 7-ET- and 7-Br-DMT possess a higher serotonin receptor affinity than DMT, neither produce behavioral effects which parallel those of 5-OMe-DMT. In contrast, 6-Me-DMT and its 5-OMe derivative do not interact with the serotonin receptors in a competitive manner and are inactive in the discriminative stimulus assay.