phenyl(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)methanone | 16143-96-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenyl(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)methanone
• 英文别名: [4-(Oxan-2-yloxy)phenyl]-phenylmethanone
• CAS: 16143-96-7
• 化学式: C₁₈H₁₈O₃
• 分子量: 282.339
• InChiKey: UXIJSXWONXSCBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  phenyl(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)methanone 在 palladium on activated charcoal 、 氢气 、 三氟乙酸 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙酸乙酯 为溶剂， 生成 ethyl 3-(4-hydroxyphenyl)-3-phenylpropanoate
  参考文献：
  名称：

  Discovery of the imidazole-derived GPR40 agonist AM-3189

  摘要：

  As a follow-up to the GPR40 agonist AMG 837, which was evaluated in clinical trials for the treatment of type II diabetes, further optimization led to the discovery of AM-3189 (13k). AM-3189 is representative of a new class of compounds with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.11.050
• 作为产物：
  描述：

  magnesium,2-(phenoxy)oxane,bromide 在 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 phenyl(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)methanone
  参考文献：
  名称：

  Discovery of the imidazole-derived GPR40 agonist AM-3189

  摘要：

  As a follow-up to the GPR40 agonist AMG 837, which was evaluated in clinical trials for the treatment of type II diabetes, further optimization led to the discovery of AM-3189 (13k). AM-3189 is representative of a new class of compounds with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.11.050

文献信息

• Polyarylene, Process For Producing The Same, Solid Polyelectrolyte, And Proton-Conductive Film
  申请人：Yamakawa Yoshitaka

  公开号：US20080015389A1

  公开（公告）日：2008-01-17

  A polyarylene having a structural unit shown by the following formula (1) is disclosed. wherein X and Y indicate a divalent organic group or a single bond, Z shows an oxygen atom or a sulfur atom, R represents at least one atom or group selected from the group consisting of a hydrogen atom, a fluorine atom, an alkyl group, and a fluorine-substituted alkyl group, a is an integer of 1 to 20, n is an integer of 1 to 5, and p is an integer of 1 to 10.

  披氏芳烃具有以下公式（1）所示的结构单元，其中X和Y表示二价有机基团或单键，Z表示氧原子或硫原子，R代表至少选择自氢原子、氟原子、烷基团和氟代烷基团组成的一种原子或基团，a为1至20之间的整数，n为1至5之间的整数，p为1至10之间的整数。
• A catalyst-free synthesis of asymmetric diaryl ketones from aryltins
  作者：Gustavo F. Silbestri、Romina Bogel Masson、María T. Lockhart、Alicia B. Chopa

  DOI：10.1016/j.jorganchem.2005.12.027

  日期：2006.4

  A series of diaryl ketones have been synthesized in good yields (40–78%) through the catalyst-free reaction of trimethylarylstannanes with aroyl chlorides in chlorobenzene as solvent. In addition, an attractive feature is that these reactions are completely regioselective making possible the synthesis of diarylketones which are not usually available under the influence of the directing forces of the

  通过三甲基芳基锡烷与芳酰氯在氯苯中作为溶剂的无催化剂反应，已合成了一系列高收率（40-78％）的二芳基酮。另外，一个吸引人的特征是这些反应是完全区域选择性的，使得二芳基酮的合成成为可能，该二芳基酮通常在存在于芳环中的取代基的导向力的影响下是不可用的。而且，反应条件温和到足以适用于酸敏感性分子。
• Zirconium sulfophenyl phosphonate as a heterogeneous catalyst in tetrahydropyranylation of alcohols and phenols
  作者：Massimo Curini、Francesco Epifano、Maria Carla Marcotullio、Ornelio Rosati、Umberto Costantino

  DOI：10.1016/s0040-4039(98)01817-6

  日期：1998.10

  Zirconium Sulfophenyl Phosphonate Zr(O3PCH3)(1.2)(O3PC6H4SO3H)(0.8) was found to be an efficient heterogeneous catalyst for the tetrahydropyranylation of alcohols and phenols. (C) 1998 Elsevier Science Ltd. All rights reserved.
• US3940407A
  申请人：——

  公开号：US3940407A

  公开（公告）日：1976-02-24
• US7893303B2
  申请人：——

  公开号：US7893303B2

  公开（公告）日：2011-02-22