1-chloro-2-methoxy-buta-1,3-diene | 58369-90-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: 1-chloro-2-methoxy-buta-1,3-diene
• 英文别名: 1-Chlor-2-methoxy-buta-1,3-dien；(1Z)-1-chloro-2-methoxybuta-1,3-diene
• CAS: 58369-90-7
• 化学式: C₅H₇ClO
• 分子量: 118.563
• InChiKey: OJSFTRQUYKRDRZ-PLNGDYQASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  乙烯基乙炔 、 甲醇 在 氯 作用下， 生成 1-chloro-2-methoxy-buta-1,3-diene
  参考文献：
  名称：

  Baum; Vogt; Hennion, Journal of the American Chemical Society, 1939, vol. 61, p. 1459

  摘要：

  DOI：

文献信息

• PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS
  申请人：Omeros Corporation

  公开号：US20170152238A1

  公开（公告）日：2017-06-01

  Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing a compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.
• Baum; Vogt; Hennion, Journal of the American Chemical Society, 1939, vol. 61, p. 1459
  作者：Baum、Vogt、Hennion

  DOI：——

  日期：——