4-(dimethylamino)-2-propoxybenzaldehyde | 1268353-45-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(dimethylamino)-2-propoxybenzaldehyde
• 英文别名: 4-(Dimethylamino)-2-propoxybenzaldehyde
• CAS: 1268353-45-2
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: ZPCOWRSVMGZPHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(dimethylamino)-2-propoxybenzaldehyde 、 2,3-diaminomaleonitrile 在 哌啶 作用下， 以 苯 为溶剂， 反应 8.0h， 以46.5%的产率得到2,3-bis((4-(dimethylamino)-2-propoxybenzylidene)amino)but-2-enedinitrile
  参考文献：
  名称：

  Effect of phenyl ring substitution on J-aggregate formation ability of novel bisazomethine dyes in vapour-deposited films

  摘要：

  Bisazomethine dyes, which are synthesized using diaminomaleonitrile and aminobenzaldehydes, exhibit red fluorescence in solution and in the solid state. Several bisazomethine dyes are known to form J-aggregates in vapour-deposited films. In this work, novel bisazomethine dyes were synthesized and the effect of phenyl ring substitution on the J-aggregate formation in vapour-deposited films was examined. The optical properties of the dyes were examined in solution and in the solid state through molecular orbital calculations. Four derivatives were found to form J-aggregates in vapour-deposited films as determined from the shape of the spectrum and the absorption edge. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2010.11.009
• 作为产物：
  描述：

  3-羟基-N,N-二甲基苯胺 在 potassium carbonate 、 三氯氧磷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 4-(dimethylamino)-2-propoxybenzaldehyde
  参考文献：
  名称：

  Effect of phenyl ring substitution on J-aggregate formation ability of novel bisazomethine dyes in vapour-deposited films

  摘要：

  Bisazomethine dyes, which are synthesized using diaminomaleonitrile and aminobenzaldehydes, exhibit red fluorescence in solution and in the solid state. Several bisazomethine dyes are known to form J-aggregates in vapour-deposited films. In this work, novel bisazomethine dyes were synthesized and the effect of phenyl ring substitution on the J-aggregate formation in vapour-deposited films was examined. The optical properties of the dyes were examined in solution and in the solid state through molecular orbital calculations. Four derivatives were found to form J-aggregates in vapour-deposited films as determined from the shape of the spectrum and the absorption edge. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2010.11.009

文献信息

• QUINOLIN-2(1H)-ONE INHIBITORS OF LATE SV40 FACTOR
  申请人：TRUSTEES OF BOSTON UNIVERSITY

  公开号：US20220062272A1

  公开（公告）日：2022-03-03

  The present invention is directed to compositions, methods and kits for treatment of cancer, e.g., hepatocellular carcinoma (HCC). In some embodiments, the present invention discloses the use of a small-molecule compounds of Formula (I) to inhibit tubulin acetylation, to inhibit cell migration, or to modulate cell compaction.

  本发明涉及用于治疗癌症（例如肝细胞癌）的组合物、方法和试剂盒。在某些实施例中，本发明揭示了使用式（I）的小分子化合物来抑制微管蛋白乙酰化、抑制细胞迁移或调节细胞紧密度。
• NOUVEAUX DERIVES HYDRAZIDE OU HYDRAZONE DE L ACIDE HEXAHYDRO -PYRIDAZINE-3-CARBOXYLIQUE, CHIMIOTHEQUES LES CONTENANT, LEUR UTILISATION COMME MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEURS PROCEDES DE PREPARATION
  申请人：Aventis Pharma S.A.

  公开号：EP1515953A2

  公开（公告）日：2005-03-23
• [EN] NOVEL HEXAHYDRO-PYRIDAZINE-3-CARBOCYLIC ACID HYDRAZIDE OR HYDRAZONE DERIVATIVES, COMBINATORIAL LIBRARIES CONTAINING SAME, USE THEREOF AS MEDICINES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND METHODS FOR PREPARING SAME<br/>[FR] NOUVEAUX DERIVES HYDRAZIDE OU HYDRAZONE DE L'ACIDE HEXAHYDRO-PYRIDAZINE-3-CARBOXYLIQUE, CHIMIOTHEQUES LES CONTENANT, LEUR UTILISATION COMME MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEURS PROCEDES DE PREPARATION
  申请人：AVENTIS PHARMA SA

  公开号：WO2003106431A2

  公开（公告）日：2003-12-24

  L'invention a pour objet un composé de formule générale (I). L'invention a aussi pour objet les chimiothèques les contenant, leur utilisation comme médicaments, compositions pharmaceutiques et leurs procédés de préparation.
• Effect of phenyl ring substitution on J-aggregate formation ability of novel bisazomethine dyes in vapour-deposited films
  作者：Byung-Soon Kim、Daisuke Kashibuchi、Young-A. Son、Sung-Hoon Kim、Shinya Matsumoto

  DOI：10.1016/j.dyepig.2010.11.009

  日期：2011.7

  Bisazomethine dyes, which are synthesized using diaminomaleonitrile and aminobenzaldehydes, exhibit red fluorescence in solution and in the solid state. Several bisazomethine dyes are known to form J-aggregates in vapour-deposited films. In this work, novel bisazomethine dyes were synthesized and the effect of phenyl ring substitution on the J-aggregate formation in vapour-deposited films was examined. The optical properties of the dyes were examined in solution and in the solid state through molecular orbital calculations. Four derivatives were found to form J-aggregates in vapour-deposited films as determined from the shape of the spectrum and the absorption edge. (C) 2010 Elsevier Ltd. All rights reserved.