N-butyl-N-methylacrylamide | 57181-89-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-butyl-N-methylacrylamide
• 英文别名: N-butyl methyl acrylamide；N-butyl-N-methylprop-2-enamide
• CAS: 57181-89-2
• 化学式: C₈H₁₅NO
• 分子量: 141.213
• InChiKey: OWVWGCVNBQLTDH-UHFFFAOYSA-N

物化性质

• 沸点：
  238.9±9.0 °C(Predicted)
• 密度：
  0.882±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-butyl-N-methylacrylamide 在 sodium azide 、 溴 、 caesium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 26.0h， 生成 N-butyl-1-(2-chlorophenyl)-N-methylpyrrolo[1,2-a]pyrazine-3-carboxamide
  参考文献：
  名称：

  Design, synthesis and anxiolytic-like activity of 1-arylpyrrolo[1,2-a]pyrazine-3-carboxamides

  摘要：

  A series of 1-arylpyrrolo[1,2-a] pyrazine-3-carboxamides were designed and synthesized as 18 kDa translocator protein (TSPO) ligands. Anxiolytic-like activity of compounds was evaluated in the open field test and elevated plus maze test. Compounds 1a and 1b demonstrated high anxiolytic-like effect in the dose range of 0.1-1.0 mg/kg comparable with that of diazepam. The involvement of TSPO receptor in the mechanism of anxiolytic-like activity of new compounds was proved by antagonism of the most active compound 1a with TSPO selective inhibitor PK11195. In vitro binding studies demonstrated high TSPO affinities for compounds 1a and 1b. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.04.049
• 作为产物：
  描述：

  甲基丁胺 、 丙烯酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以80%的产率得到N-butyl-N-methylacrylamide
  参考文献：
  名称：

  Design, synthesis and anxiolytic-like activity of 1-arylpyrrolo[1,2-a]pyrazine-3-carboxamides

  摘要：

  A series of 1-arylpyrrolo[1,2-a] pyrazine-3-carboxamides were designed and synthesized as 18 kDa translocator protein (TSPO) ligands. Anxiolytic-like activity of compounds was evaluated in the open field test and elevated plus maze test. Compounds 1a and 1b demonstrated high anxiolytic-like effect in the dose range of 0.1-1.0 mg/kg comparable with that of diazepam. The involvement of TSPO receptor in the mechanism of anxiolytic-like activity of new compounds was proved by antagonism of the most active compound 1a with TSPO selective inhibitor PK11195. In vitro binding studies demonstrated high TSPO affinities for compounds 1a and 1b. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.04.049

文献信息

• PI3 KINASE INHIBITORS AND USES THEREOF
  申请人：NIU DEQIANG

  公开号：US20110230476A1

  公开（公告）日：2011-09-22

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用相同的方法。
• ERK INHIBITORS AND USES THEREOF
  申请人：Celgene Avilomics Research, Inc.

  公开号：US20140228322A1

  公开（公告）日：2014-08-14

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用它们的方法。
• SILICONE COMPOUND HAVING A RADICAL-POLYMERIZABLE GROUP AND A METHOD FOR THE PREPARATION THEREOF
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20150087853A1

  公开（公告）日：2015-03-26

  A purpose of the present invention is to provide a polymerizable group-containing silicone compound which is liquid at room temperature, has good handling properties and compatibility with other polymerizable monomers. The present invention provides a silicone compound represented by the general formula (1) which has a structure represented by the following formula (2) or (3): wherein R c is an alkyl group having 1 to 10 carbon atoms and Z is a radical-polymerizable group; wherein p 1 and p 2 are, independently of each other, positive integers such that a total number of p 1 and p 2 is 3 to 10, and Z is a radical-polymerizable group; and has a silicone structure bonded to the aforesaid formula (2) or (3) via a substituted or unsubstituted divalent hydrocarbon group having 1 to 10 carbon atoms. The present invention further provides a method for preparation the aforesaid silicone compound.

  本发明的目的是提供一种聚合物化基团含硅化合物，该化合物在室温下为液体，具有良好的操控性能和与其他可聚合单体的相容性。本发明提供了一种由一般式(1)表示的硅氧烷化合物，其具有以下式(2)或(3)表示的结构：其中Rc是具有1至10个碳原子的烷基基团，Z是一个基团-可聚合基团；其中p1和p2是彼此独立的正整数，使得p1和p2的总数为3至10，Z是一个基团-可聚合基团；并且具有通过具有1至10个碳原子的取代或未取代的二价碳氢基团与上述式(2)或(3)结合的硅氧烷结构。本发明还提供了制备上述硅氧烷化合物的方法。
• HETEROARYL COMPOUNDS AND USES THEREOF
  申请人：Singh Juswinder

  公开号：US20100249092A1

  公开（公告）日：2010-09-30

  The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

  本发明提供化合物及其药学上可接受的组成物，以及使用它们的方法。
• HCV PROTEASE INHIBITORS AND USES THEREOF
  申请人：Niu Deqiang

  公开号：US20100041591A1

  公开（公告）日：2010-02-18

  The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

  本发明提供化合物、药学上可接受的组合物以及使用它们的方法。