L-glutamic acid γ-p-nitroanilide methyl ester | 706757-21-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-glutamic acid γ-p-nitroanilide methyl ester
• 英文别名: methyl (2S)-2-amino-5-(4-nitroanilino)-5-oxopentanoate
• CAS: 706757-21-3
• 化学式: C₁₂H₁₅N₃O₅
• 分子量: 281.268
• InChiKey: WKSQBJPGNJVZHM-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  双甘肽 、 L-glutamic acid γ-p-nitroanilide methyl ester 在 HCl buffer 、 rat kidney γ-glutamyltranspeptidase 作用下， 生成 Glu-Gly-Gly
  参考文献：
  名称：

  Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and Their kinetic studies with γ-Glutamyltranspeptidase

  摘要：

  A new series Of L-glutamic acid p-nitroanilide analogues has been synthesized and tested as substrates and inhibitors of rat kidney gamma-glutamyltranspeptidase (GGT). Kinetic parameters (K-m and k(cat)) were determined for each analogue and provide insight into the scope and limits of GGT catalytic efficiency. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00083-0
• 作为产物：
  描述：

  (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-(4-nitro-phenylcarbamoyl)-butyric acid methyl ester 在 肼 作用下， 以 甲醇 为溶剂， 生成 L-glutamic acid γ-p-nitroanilide methyl ester
  参考文献：
  名称：

  Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and Their kinetic studies with γ-Glutamyltranspeptidase

  摘要：

  A new series Of L-glutamic acid p-nitroanilide analogues has been synthesized and tested as substrates and inhibitors of rat kidney gamma-glutamyltranspeptidase (GGT). Kinetic parameters (K-m and k(cat)) were determined for each analogue and provide insight into the scope and limits of GGT catalytic efficiency. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00083-0

文献信息

• Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and Their kinetic studies with γ-Glutamyltranspeptidase
  作者：Christian Lherbet、Mylène Morin、Roselyne Castonguay、Jeffrey W Keillor

  DOI：10.1016/s0960-894x(03)00083-0

  日期：2003.3

  A new series Of L-glutamic acid p-nitroanilide analogues has been synthesized and tested as substrates and inhibitors of rat kidney gamma-glutamyltranspeptidase (GGT). Kinetic parameters (K-m and k(cat)) were determined for each analogue and provide insight into the scope and limits of GGT catalytic efficiency. (C) 2003 Elsevier Science Ltd. All rights reserved.