2-(4-ethylphenyl)-4,5-diphenyl-1H-imidazole | 331984-05-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-ethylphenyl)-4,5-diphenyl-1H-imidazole
• CAS: 331984-05-5
• 化学式: C₂₃H₂₀N₂
• 分子量: 324.425
• InChiKey: PAYCQQWPVMVJMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  联苯甲酰 、 4-乙基苯甲醛 在 ammonium acetate 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以91%的产率得到2-(4-ethylphenyl)-4,5-diphenyl-1H-imidazole
  参考文献：
  名称：

  非均相条件下UO 2（NO 3）2·6H 2 O催化高效，新颖的一锅合成2,4,5-三芳基-1 H-咪唑

  摘要：

  硝酸铀酰六水合物[UO 2（NO 3）2 ·6H]催化的高效，便捷，新颖的一锅法，使用苄基苯，芳烃甲醛和乙酸铵合成2,4,5-三芳基-1 H-咪唑据报道，负载在酸性氧化铝上的2 O]在非均相条件下可产生良好至极好的收率。通过UV-VIS光谱数据证实了反应物-催化剂配合物的形成。还研究了合成化合物的抗菌（MIC）和抗氧化活性。

  DOI：

  10.2478/s11696-011-0028-z

文献信息

• Highly efficient one-pot synthesis of trisubstituted imidazoles under catalyst-free conditions
  作者：Najmadin Azizi、Nairreh Dado、Alireza Khajeh Amiri

  DOI：10.1139/v11-141

  日期：2012.2

  Operationally simple, atom economical, and scalable synthesis of 2,4,5-trisubstituted imidazoles from benzil, aldehydes, and ammonium acetate is shown to proceed readily in methanol with high yield. The scope of the reaction is quite broad; a variety of aromatic and aliphatic activated and unactivated aldehydes have all been shown to be viable substrates for this reaction. Excellent yields and purity were obtained by washing the products with hot ethanol.

  操作简单，原子经济，可扩展的合成2,4,5-三取代咪唑的方法从苯二酮、醛和醋酸铵开始，在甲醇中迅速进行，产率高。该反应的范围非常广泛；各种芳香族和脂肪族活化和未活化的醛都被证明是这种反应的可行底物。通过用热乙醇洗涤产物，得到了优异的产率和纯度。
• ZrO₂-β-cyclodextrin catalyzed synthesis of 2,4,5-trisubstituted imidazoles and 1,2-disubstituted benzimidazoles under solvent free conditions and evaluation of their antibacterial study
  作者：Yarabhally R. Girish、Kothanahally S. Sharath Kumar、Kuntebommanahalli N. Thimmaiah、Kanchugarakoppal S. Rangappa、Sheena Shashikanth

  DOI：10.1039/c5ra13891d

  日期：——

  A series of 2,4,5-trisubstituted imidazoles and 1,2-disubstituted benzimidazoles catalyzed by ZrO₂-supported-β-cyclodextrin (ZrO₂-β-CD) under solvent free conditions have been synthesized and characterized by spectral methods.

  通过ZrO₂支持的β-环糊精（ZrO₂-β-CD）催化的一系列2,4,5-三取代咪唑和1,2-二取代苯并咪唑在无溶剂条件下合成，并通过光谱方法进行了表征。
• DABCO as a mild and efficient catalytic system for the synthesis of highly substituted imidazoles via multi-component condensation strategy
  作者：S. Narayana Murthy、B. Madhav、Y.V.D. Nageswar

  DOI：10.1016/j.tetlet.2010.07.128

  日期：2010.10

  A simple and efficient protocol for the synthesis of highly substituted imidazoles is developed through the condensation of 1,2-dicarbonyl compound, aldehyde, and ammonium acetate or amine via multi-component condensation strategy. The present method gives good to excellent yields of substituted imidazoles.

  通过多组分缩合策略缩合1,2-二羰基化合物，醛和乙酸铵或胺，开发了一种简单高效的合成高度取代的咪唑的方法。本方法使取代的咪唑的收率良好至优异。
• A novel bioglycerol-based recyclable carbon catalyst for an efficient one-pot synthesis of highly substituted imidazoles
  作者：K. Ramesh、S. Narayana Murthy、K. Karnakar、Y.V.D. Nageswar、Kukuma Vijayalakhshmi、Bethala L.A. Prabhavathi Devi、R.B.N. Prasad

  DOI：10.1016/j.tetlet.2011.12.092

  日期：2012.2

  The new bioglycerol-based carbon catalyst acts as an efficient, readily available, and reusable catalyst for the synthesis of 2,4,5-trisubstituted imidazoles/1,2,4,5-tetrasubstituted imidazoles, when aromatic aldehyde, ammonium acetate/amine, and 1,2-diketone are reacted in acetonitrile. (C) 2011 Elsevier Ltd. All rights reserved.