1-(6-methylpyridin-2-yl)nonan-3-ol | 92512-83-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(6-methylpyridin-2-yl)nonan-3-ol
• 英文别名: 2-Methyl-6-(3-hydroxynonyl)pyridine
• CAS: 92512-83-9
• 化学式: C₁₅H₂₅NO
• 分子量: 235.37
• InChiKey: DGKNUARKWNZXSN-UHFFFAOYSA-N

物化性质

• 沸点：
  346.1±27.0 °C(Predicted)
• 密度：
  0.959±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(6-methylpyridin-2-yl)nonan-3-ol 在 吡啶 、 盐酸 、 重铬酸吡啶 、 对甲苯磺酸 、 三氟乙酸 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 2.0h， 生成 2-hexyl-2-[2-(6-methylpyridyl)-ethyl]-1,3-dioxolane
  参考文献：
  名称：

  摘要：

  The venom alkaloids from the workers of nine collections of Solenopsis (Diplorhoptrum) from California contain either (5E,9E)-3-hexyl-5-methylindolizidine (Ic) or (5Z,9E)-3-hexyl-5-methylindolizidine (Id) along with cis-2-methyl-6-nonylpiperidine. The structures of these compounds were determined from their mass spectra and by comparison of their GC-FTIR spectra with those of a synthetic mixture. In view of the facts that a third diastereomer of 3-hexyl-5-methylindolizidine had been reported in previous collections of Solenopsis (Diplorhoptrum) queens from Puerto Rico, and that indolizidines along with other ant venom alkaloids are sequestered by amphibians, the determination of species in this difficult group of ants is significant. In particular, the chemotaxonomic value of the stereochemistry of these venom alkaloids is discussed.

  DOI：

  10.1023/a:1022381719471
• 作为产物：
  描述：

  1-(6-methylpyridin-2-yl)-1-(phenylthio)-nonan-3-ol 在 镍 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以75%的产率得到1-(6-methylpyridin-2-yl)nonan-3-ol
  参考文献：
  名称：

  Alkylation of 2-Substituted (6-Methyl-2-pyridyl)methyllithium Species with Epoxides

  摘要：

  Substituted (6-methyl-2-pyridyl)methyllithium species were reacted with 1,2-epoxyoctane and 2-methyl-2,3-epoxynonane. The monosubstituted epoxide reacted efficiently with lutidyllithium and a number of 2-substituted (6-methyl-2-pyridyl)methyllithium derivatives. The trisubstituted epoxide gave low yields of adducts with all (2-pyridyl)methyllithium species studied. These results are discussed in the context of a proposed synthesis of cananodine.

  DOI：

  10.1021/jo802267n