雷索替丁 | 84071-15-8

• 物质功能分类: 原料药 - 消化系统用药 - 抗酸及胃黏膜保护药
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 雷索替丁
• 英文名称: N-[2-(5-dimethylaminomethylfuran-2-ylmethylthio)ethyl]-3-pyridinecarboxamide 1-oxide
• 英文别名: ramixotidine；N-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-oxidopyridin-1-ium-3-carboxamide
• CAS: 84071-15-8
• 化学式: C₁₆H₂₁N₃O₃S
• 分子量: 335.427
• InChiKey: HIVRCMFJEMKPDS-UHFFFAOYSA-N

物化性质

• 沸点：
  592.3±50.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  96.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Pharmaceutical preparation comprising an active dispersed on a matrix
  申请人：——

  公开号：US20040058896A1

  公开（公告）日：2004-03-25

  The present invention relates to the field of pharmaceutical technology and describes a novel advantageous preparation for an active ingredient. The novel preparation is suitable for producing a large number of pharmaceutical dosage forms. In the new preparation an active ingredient is present essentially uniformly dispersed in an excipient matrix composed of one or more excipients selected from the group of fatty alcohol, triglyceride, partial glyceride and fatty acid ester.

  本发明涉及制药技术领域，描述了一种新的有利的活性成分制备方法。这种新的制备方法适用于生产大量的药物剂型。在这种新的制备方法中，活性成分基本上均匀地分散在由脂肪醇、甘油三酯、部分甘油酯和脂肪酸酯等多种赋形剂中选择的一种或多种赋形剂组成的赋形剂基质中。
• Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
  申请人：Scaramuzzino, Giovanni

  公开号：EP1336602A1

  公开（公告）日：2003-08-20

  New pharmaceutical compounds of general formula (I): F-(X)q where q is an integer from 1 to 5, preferably 1; -F is chosen among drugs described in the text, -X is chosen among 4 groups -M, -T, -V and -Y as described in the text. The compounds of general formula (I) are nitrate prodrugs which can release nitric oxide in vivo in a controlled and selective way and without hypotensive side effects and for this reason they are useful for the preparation of medicines for prevention and treatment of inflammatory, ischemic, degenerative and proliferative diseases of musculoskeletal, tegumental, respiratory, gastrointestinal, genito-urinary and central nervous systems.

  通式（I）的新药物化合物：F-（X）q，其中q是1到5的整数，最好是1；-F是在文本中描述的药物中选择的，-X是在文本中描述的4个组-M，-T，-V和-Y中选择的。通式（I）的化合物是硝酸盐前药，可以在体内以受控和选择性的方式释放一氧化氮，而不会产生降压副作用，因此它们非常适用于制备用于预防和治疗肌肉骨骼，皮肤，呼吸，消化，泌尿和中枢神经系统的炎症，缺血，退行性和增生性疾病的药物。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• A method of applying an oral composition
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP1393710A1

  公开（公告）日：2004-03-03

  The present invention relates to a method of applying oral care benefit agent to the oral tissues. More specifically, a method for treating an oral cavity is provided comprising the application of an aqueous composition comprising oral care benefit agents to a large proportion of the oral cavity, application occurring as part of the daily oral care routine shortly before retiring, and the composition remaining in contact with the oral tissues while sleeping. The method and aqueous compositions of the invention provide overnight application and delivery of oral care benefit agents with improved ease of use and consumer aesthetics

  本发明涉及一种向口腔组织施用口腔护理剂的方法。更具体地说，本发明提供了一种治疗口腔的方法，包括将含有口腔护理剂的水性组合物涂抹在口腔的大部分区域，涂抹作为退休前不久的日常口腔护理程序的一部分，组合物在睡眠时与口腔组织保持接触。本发明的方法和水性组合物提供了口腔护理益处剂的隔夜应用和递送，并改善了使用的便利性和消费者的审美观
• A Delivery System for an Oral Care Substance using a Strip of Material having Low Flexural Stiffness
  申请人：The Procter and Gamble Company

  公开号：EP1779846A2

  公开（公告）日：2007-05-02

  The invention relates to a delivery system for delivering a phosphate to a surface of the oral cavity, the delivery system comprising a strip of flexible material and an oral care substance applied to the strip of material, the oral care substabnce comprising the phosphate such that when the delivery system is placed on the oral surface, the substance contacts the surface providing the phosphate onto the surface.

  本发明涉及一种向口腔表面输送磷酸盐的输送系统，该输送系统包括柔性材料条和涂抹在材料条上的口腔护理物质，口腔护理物质包括磷酸盐，当输送系统放置在口腔表面时，该物质与表面接触，将磷酸盐输送到表面。