1,2-Epoxy-1-vinylcyclododecene | 53601-11-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: 1,2-Epoxy-1-vinylcyclododecene
• 英文别名: 1-vinyl-13-oxabicyclo[10.1.0]tridecane；1-ethenyl-13-oxabicyclo[10.1.0]tridecane
• CAS: 53601-11-9
• 化学式: C₁₄H₂₄O
• 分子量: 208.344
• InChiKey: GKPLONGGOJXWJN-UHFFFAOYSA-N

物化性质

• 沸点：
  281.5±9.0 °C(Predicted)
• 密度：
  0.954±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-苯基硫烷基环十二烷-1-酮 在 potassium hydride 作用下， 以 四氢呋喃 、 六甲基磷酰三胺 为溶剂， 反应 48.17h， 生成 1,2-Epoxy-1-vinylcyclododecene
  参考文献：
  名称：

  Alkoxide-promoted [1,3] rearrangements of 1,3-dithianes

  摘要：

  DOI：

  10.1021/jo01300a040

文献信息

• Process for preparing epoxy compounds, aromatic compositions containing the same
  申请人：Soda Aromatic Co., Ltd.

  公开号：US06525207B1

  公开（公告）日：2003-02-25

  This invention provides a process for producing an epoxy compound industrially advantageously at low cost in a short process. Furthermore, this invention provides a novel fruity, camphoric, floral, amber or woody fragrance-, flavor- or scent-imparting composition containing said epoxy compound, and foods & drinks, perfumes, cosmetics and tobaccos containing said composition. The epoxy compound can be produced by letting an &agr;-halocyclododecanone and an organic magnesium compound react with each other for Grignard reaction, hydrolyzing to obtain a halohydrin and letting the halohydrin and a base react with each other in the presence of an phase transfer catalyst or adding an aprotic polar solvent for reaction.

  这项发明提供了一种在生产环氧化合物方面具有工业优势、成本低廉、过程短暂的工艺。此外，这项发明还提供了一种新颖的水果香、樟脑香、花香、琥珀香或木香气味-、风味-或香味赋予成分，其中包含所述环氧化合物，并且还包括含有该成分的食品和饮料、香水、化妆品和烟草。环氧化合物可以通过让α-卤代环十二酮和有机镁化合物进行格氏试剂反应，水解得到卤水合物，然后在相转移催化剂的存在下让卤水合物和碱反应，或者在无极性极性溶剂中加入一种脱水极性溶剂进行反应来制备。
• Process for producing 2-vinylcyclododecanone.
  申请人：Takasago International Corporation

  公开号：EP1162189A2

  公开（公告）日：2001-12-12

  A process for producing 2-vinylcyclododecanone, the process comprising isomerizing 2-ethylidenecyclododecanone represented by the following formula (1): wherein the wave line shows that the double bond is a Z-isomer, an E-isomer or a mixture of an E-isomer and a Z-isomer; in the presence of a catalyst and separating 2-vinylcyclododecanone represented by the following formula (2) from the reaction product by fractionation:    2-Vinylcyclododecanone can be produced using 2-ethylidenecyclododecanone, which can be manufactured simply from cyclododecanone in a high yield through no chlorination, without using any solvent having safety problems in a high yield by using a simple process involving neither washing nor solvent recovery.

  一种生产 2-乙烯基环十二酮的工艺，该工艺包括将下式(1)代表的 2-亚乙基环十二酮异构化： 其中波浪线表示双键是 Z-异构体、E-异构体或 E-异构体和 Z-异构体的混合物；在催化剂存在下，通过分馏从反应产物中分离出下式（2）代表的 2-乙烯基环十二酮： 可以使用 2-亚乙基环十二酮生产 2-乙烯基环十二酮，这种环十二酮可以简单地从环 十二酮中生产出来，无需氯化，不使用任何有安全问题的溶剂，采用简单的工艺，既不 涉及洗涤，也不涉及溶剂回收，产量很高。
• PROCESS FOR PREPARING EPOXY COMPOUNDS, AROMATIC COMPOSITIONS CONTAINING THE COMPOUNDS, AND DRINKS, PERFUMES, COSMETICS, CIGARETTES, AND TOBACCOS CONTAINING THE COMPOSITIONS
  申请人：SODA AROMATIC COMPANY, LIMITED

  公开号：EP1316551A1

  公开（公告）日：2003-06-04

  This invention provides a process for producing an epoxy compound industrially advantageously at low cost in a short process. Furthermore, this invention provides a novel fruity, camphoric, floral, amber or woody fragrance-, flavor- or scent-imparting composition containing said epoxy compound, and foods & drinks, perfumes, cosmetics and tobaccos containing said composition. In this invention, the epoxy compound can be produced by letting an a-halocyclododecanone represented by the following general formula (1) (where X1 denotes chlorine, bromine or iodine) and an organic magnesium compound represented by the following general formula (2)         R1MgX1     (2) (where R1 denotes an alkyl group with 1 to 5 carbon atoms, alkenyl group with 2 to 5 carbon atoms or alkynyl group with 2 to 5 carbon atoms, and X1 denotes chlorine, bromine or iodine) react with each other for Grignard reaction, hydrolyzing to obtain a halohydrin represented by the following general formula (3) (where R1 denotes an alkyl group with 1 to 5 carbon atoms, alkenyl group with 2 to 5 carbon atoms or alkynyl group with 2 to 5 carbon atoms; X1 denotes chlorine, bromine or iodine; and the wavy line denotes cis form, trans form or a mixture consisting of cis form and trans form), and letting the halohydrin and a base react with each other in the presence of an phase transfer catalyst or adding an aprotic polar solvent for reaction.

  本发明提供了一种工业化生产环氧化合物的工艺，该工艺成本低，流程短。此外，本发明还提供了一种含有所述环氧化合物的新型果味、樟脑味、花香、琥珀香或木香的香料、香精或香味诱导组合物，以及含有所述组合物的食品和饮料、香水、化妆品和烟草。 在本发明中，环氧化合物可以通过以下通式（1）代表的 a-卤代环十二酮来生产 (其中 X1 表示氯、溴或碘）和由以下通式（2）表示的有机镁化合物 R1MgX1 (2) (其中 R1 表示具有 1 至 5 个碳原子的烷基、具有 2 至 5 个碳原子的烯基或具有 2 至 5 个碳原子的炔基，X1 表示氯、溴或碘）相互反应，进行格氏反应，水解得到由以下通式（3）表示的卤代醇 (其中 R1 表示 1 至 5 个碳原子的烷基、2 至 5 个碳原子的烯基或 2 至 5 个碳原子的炔基；X1 表示氯、溴或碘；波浪线表示顺式、反式或由顺式和反式组成的混合物），让卤代醇和碱在相转移催化剂存在下相互反应，或加入非沸腾极性溶剂进行反应。
• Composition based on a vegetable extract for the treatment of cutaneous inflammatory forms, in particular psoriasis.
  申请人：Oser S.r.l.

  公开号：EP2554179A1

  公开（公告）日：2013-02-06

  The present invention concerns, in one aspect, a composition comprising an extract of beet plant in a biologically active amount and a physiologically acceptable excipient or carrier. The composition of the invention finds application in the dermatological or cosmetic treatment of inflammatory skin affection such as reddening or psoriatic lesions.

  本发明的一个方面涉及一种组合物，该组合物包含具有生物活性的甜菜植物提取物和生理上可接受的赋形剂或载体。本发明的组合物可用于皮肤病或美容治疗，如皮肤发红或牛皮癣等炎症性皮肤病。
• JP2003089635A
  申请人：——

  公开号：JP2003089635A

  公开（公告）日：2003-03-28