4-(4-Chlor-phenoxy)-pyridin | 28231-84-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(4-Chlor-phenoxy)-pyridin
• 英文别名: 4-(4-Chlorophenoxy)pyridine
• CAS: 28231-84-7
• 化学式: C₁₁H₈ClNO
• 分子量: 205.644
• InChiKey: BJAMKBIPIKVOEO-UHFFFAOYSA-N

物化性质

• 沸点：
  306.2±17.0 °C(Predicted)
• 密度：
  1.244±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(4-Chlor-phenoxy)-pyridin 在 sodium tetrahydroborate 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  Oxamides as novel NR2B selective NMDA receptor antagonists

  摘要：

  A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.053
• 作为产物：
  描述：

  4-氯吡啶 、 对氯苯酚 在 1-(4-吡啶基)吡啶氯盐酸盐 作用下， 反应 6.0h， 生成 4-(4-Chlor-phenoxy)-pyridin
  参考文献：
  名称：

  Oxamides as novel NR2B selective NMDA receptor antagonists

  摘要：

  A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.053

文献信息

• Low Catalyst Loadings for Copper-Catalyzed O-Arylation of Phenols with Aryl and Heteroaryl Halides under Mild Conditions
  作者：Yong-Chua Teo、Fui-Fong Yong、Yaw-Kai Yan、Guan-Leong Chua

  DOI：10.1055/s-0031-1290110

  日期：2012.1

  A practical and mild strategy has been developed for the cross-coupling of O-arylation of phenol with differently substituted aryl halides and heteroaryl iodides using low catalyst loading of copper iodide under low operating temperature in DMF with TMHD as the ligand and Cs2CO3 as the base. This method tolerates a variety of functional groups including sterically hindered phenols and heteroaryl iodides

  已经开发了一种实用且温和的策略，用于在 DMF 中以 TMHD 为配体和 Cs2CO3 为碱，在低操作温度下，使用低催化剂负载量的碘化铜将苯酚与不同取代的芳基卤化物和杂芳基碘化物的 O-芳基化交叉偶联. 该方法可耐受各种官能团，包括空间位阻酚和杂芳基碘化物，以提供良好至极好的产率（高达 95%）的产品。
• US4218456A
  申请人：——

  公开号：US4218456A

  公开（公告）日：1980-08-19
• Oxamides as novel NR2B selective NMDA receptor antagonists
  作者：Gizella Barta-Szalai、István Borza、Éva Bozó、Csilla Kiss、Béla Ágai、Ágnes Proszenyák、György M Keserű、Anikó Gere、Sándor Kolok、Kornél Galgóczy、Csilla Horváth、Sándor Farkas、György Domány

  DOI：10.1016/j.bmcl.2004.05.053

  日期：2004.8

  A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test. (C) 2004 Elsevier Ltd. All rights reserved.