Aceton-(2-pyridyl)hydrazon | 19848-72-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Aceton-(2-pyridyl)hydrazon
• 英文别名: Aceton-pyridyl-(2)-hydrazon；3-Methyl-1-(pyridyl-2)-1,2-diaza.buten-2；acetone-[2]pyridylhydrazone；N-(propan-2-ylideneamino)pyridin-2-amine
• CAS: 19848-72-7
• 化学式: C₈H₁₁N₃
• 分子量: 149.195
• InChiKey: OFYFYHPWFDCWAA-UHFFFAOYSA-N

物化性质

• 熔点：
  73 °C
• 沸点：
  249.7±32.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Aceton-(2-pyridyl)hydrazon 在 羰基镁 、 sodium carbonate 、 三(4-三氟甲苯基)膦 作用下， 以 1,4-二氧六环 、 甲苯 为溶剂， 60.0~100.0 ℃ 、101.33 kPa 条件下， 反应 34.0h， 生成 ethyl 2,2-difluoro-2-{3-(4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)phenyl}acetate
  参考文献：
  名称：

  锰催化的羰基化环化用于氧化还原中性后期多样化

  摘要：

  廉价，无毒的锰催化剂可在环境压力下实现前所未有的氧化还原中性羰基环化反应。锰催化剂的性能优于所有其他常用的碱金属和贵金属催化剂。充足的底物范围反映了锰催化歧管出色的多功能性，为在无消旋条件下对许多市售药物和天然产物（包括生物碱，氨基酸，类固醇和碳水化合物）进行有效的后期操作奠定了基础。

  DOI：

  10.1002/anie.201801111
• 作为产物：
  描述：

  1-甲基-2-吡啶酮 在 五氯化磷 、 一水合肼 、 三氯氧磷 作用下， 生成 Aceton-(2-pyridyl)hydrazon
  参考文献：
  名称：

  Fargher; Furness, Journal of the Chemical Society, 1915, vol. 107, p. 695

  摘要：

  DOI：

文献信息

• Surface Modifications and Methods for their Synthesis and Use
  申请人：McGall Glenn H.

  公开号：US20110143966A1

  公开（公告）日：2011-06-16

  Novel processes are disclosed for forming an array of polymers by functionalizing the surface of particles by methods that include covalently attaching a functionalized silicon compound. Substrates such as microparticles having functionalized silicon compounds attached thereto are produced by introducing at least one carboxyl group directly by silanating a carboxylated silane compound to the surface of a microparticle. In a further aspect of the invention, the silane compound is a dipodal carboxylated silane.

  本发明公开了用于形成聚合物阵列的新颖工艺，包括通过共价连接功能化硅化合物来功能化粒子表面。通过向微粒子表面引入至少一个羧基团，直接将羧基化硅烷化合物偶联到微粒子表面，从而生产出附着有功能化硅化合物的基材，例如微粒子。在本发明的另一方面，所述硅烷化合物是双官能团羧基硅烷。
• SURFACE MODIFICATIONS AND METHODS FOR THEIR SYNTHESIS AND USE
  申请人：McGALL Glenn H.

  公开号：US20110143967A1

  公开（公告）日：2011-06-16

  Novel processes are disclosed for forming an array of polymers by functionalizing the surface of particles by methods that include covalently attaching a functionalized silicon compound. Substrates such as microparticles having functionalized silicon compounds attached thereto are produced by introducing at least one carboxyl group directly by silanating a carboxylated silane compound to the surface of a microparticle. In a further aspect of the invention, the silane compound is a dipodal carboxylated silane.

  本发明揭示了通过将功能化硅化合物共价连接到颗粒表面的方法来形成聚合物阵列的新型工艺。通过硅烷化羧化硅烷化合物直接引入至少一个羧基到微粒表面，制备具有功能化硅化合物的基底，如具有功能化硅化合物的微粒。在发明的另一方面，硅烷化合物是二极羧化硅烷。
• Weinmaier, Josef Helmut; Brunnhuber, Gabriele; Schmidpeter, Alfred, Chemische Berichte, 1980, vol. 113, # 6, p. 2278 - 2290
  作者：Weinmaier, Josef Helmut、Brunnhuber, Gabriele、Schmidpeter, Alfred

  DOI：——

  日期：——
• N-arylation of 3-alkoxypyrazoles, the case of the pyridines
  作者：Sandrine Guillou、Frédéric J. Bonhomme、Di Betina Chahine、Olivier Nesme、Yves L. Janin

  DOI：10.1016/j.tet.2010.02.032

  日期：2010.4

  In the course of a research program focused on the preparation of libraries of new chemical entities derived from 3-alkoxypyrazoles, we studied their N-pyridylation using 2, 3 or 4-bromopyridines This was achieved using Cristau and Taillefer copper-catalyzed arylation method and mostly led to the 3-alkoxy-1H-pyrazol-1-yl pyridine isomer along with lesser amount of the alternative 5-alkoxy-1H-pyrazol-1-yl pyridine The structures of these isomers were often established via their chemical tansformations and sometimes recourse to unambiguous synthetic routes for comparison purposes The alternative use of 2-fluoropyridine-based arylation was also investigated and lifted some of the limitations encountered in the course of this study (C) 2010 Elsevier Ltd All rights reserved
• WEINMAIER J. H.; BRUNNHUBER G.; SCHMIDPETER A., CHEM. BER., 1980, 113, NO 6, 2278-2290
  作者：WEINMAIER J. H.、 BRUNNHUBER G.、 SCHMIDPETER A.

  DOI：——

  日期：——