4,5,6,7-tetraethyl-2-methylpyrazolo[1,5-a]pyridine | 1260159-64-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 4,5,6,7-tetraethyl-2-methylpyrazolo[1,5-a]pyridine
• 英文别名: 4,5,6,7-Tetraethyl-2-methylpyrazolo[1,5-a]pyridine
• CAS: 1260159-64-5
• 化学式: C₁₆H₂₄N₂
• 分子量: 244.38
• InChiKey: YTFLNLQWZCAKJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  17.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-甲基吡唑 、 (3Z,5Z)-4,5-diethyl-3,6-diiodoocta-3,5-diene 在 copper(l) iodide 、 2-(phenyliminomethyl)pyridine 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以27%的产率得到4,5,6,7-tetraethyl-2-methylpyrazolo[1,5-a]pyridine
  参考文献：
  名称：

  Domino N−H/C−H Bond Activation: Copper-Catalyzed Synthesis of Nitrogen-Bridgehead Heterocycles Using Azoles and 1,4-Dihalo-1,3-dienes

  摘要：

  Copper-catalyzed tandem coupling of 1,4-dihalo-1,3-dienes with azoles via an N-H bond and its adjacent C-H bond activation has been described. The reaction exhibits good regioselectivity when unsymmetrical 1,4-dihalo-1,3-diene is employed. This method provided a novel route to the synthesis of nitrogen-bridgehead azolopyridine derivatives.

  DOI：

  10.1021/ol1026365

文献信息

• Domino N−H/C−H Bond Activation: Copper-Catalyzed Synthesis of Nitrogen-Bridgehead Heterocycles Using Azoles and 1,4-Dihalo-1,3-dienes
  作者：Qian Liao、Liyun Zhang、Shutao Li、Chanjuan Xi

  DOI：10.1021/ol1026365

  日期：2011.1.21

  Copper-catalyzed tandem coupling of 1,4-dihalo-1,3-dienes with azoles via an N-H bond and its adjacent C-H bond activation has been described. The reaction exhibits good regioselectivity when unsymmetrical 1,4-dihalo-1,3-diene is employed. This method provided a novel route to the synthesis of nitrogen-bridgehead azolopyridine derivatives.