2,6-diido-3-methoxymethoxypyridine | 437709-82-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-diido-3-methoxymethoxypyridine
• 英文别名: 2,6-Diiodo-3-methoxymethoxy-pyridine；2,6-diiodo-3-(methoxymethoxy)pyridine
• CAS: 437709-82-5
• 化学式: C₇H₇I₂NO₂
• 分子量: 390.947
• InChiKey: PDAOPJUGRFZICD-UHFFFAOYSA-N

物化性质

• 沸点：
  390.9±42.0 °C(Predicted)
• 密度：
  2.250±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-diido-3-methoxymethoxypyridine 在 2,2,6,6-四甲基哌啶 、 正丁基锂 、 silver carbonate 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 18.0h， 生成 2,6-diiodo-4-methoxy-3-methoxymethoxypyridine
  参考文献：
  名称：

  First Synthesis of Caerulomycin B. A New Synthesis of Caerulomycin C

  摘要：

  Caerulomycins produced by Streptomyces caeruleus are bipyridinic molecules endowed with antibiotic properties. The first synthesis of caerulomycin B (1) as well as a new synthesis of caerulomycin C (2) are reported. Starting from 3-hydroxypyridine, the same methodology was used to prepare both compounds 1 and 2. Efficiently controlled reactions such as metalation to allow the synthesis of 2,6-diiodo-3,4-dialkoxypyridines, which are key intermediates, and further halogen lithium exchange and cross-coupling to reach the targets molecules 1 and 2 have been developed.

  DOI：

  10.1021/jo010913r
• 作为产物：
  描述：

  2,6-二碘-3-羟基吡啶 、 氯甲基甲基醚 在 sodium hydride 作用下， 以 二甲基亚砜 为溶剂， 反应 15.5h， 以87%的产率得到2,6-diido-3-methoxymethoxypyridine
  参考文献：
  名称：

  First Synthesis of Caerulomycin B. A New Synthesis of Caerulomycin C

  摘要：

  Caerulomycins produced by Streptomyces caeruleus are bipyridinic molecules endowed with antibiotic properties. The first synthesis of caerulomycin B (1) as well as a new synthesis of caerulomycin C (2) are reported. Starting from 3-hydroxypyridine, the same methodology was used to prepare both compounds 1 and 2. Efficiently controlled reactions such as metalation to allow the synthesis of 2,6-diiodo-3,4-dialkoxypyridines, which are key intermediates, and further halogen lithium exchange and cross-coupling to reach the targets molecules 1 and 2 have been developed.

  DOI：

  10.1021/jo010913r

文献信息

• (Pyridinyl and pyrimidyl) trienoic acid derivatives as retinoid x receptor modulators
  申请人：——

  公开号：US20040248913A1

  公开（公告）日：2004-12-09

  The present invention relates to a method of modulating retinoid X receptor activity in a mammal, novel compounds and pharmaceutical compositions for modulating retinoid X receptor activity in a mammal, and methods of making compounds that modulate retinoid X receptor activity in a mammal. The compounds are represented by Structural Formula I: The compounds of Structural Formula I are efficacious insulin sensitizers and do not have the undesirable side effects of increasing triglycerides or suppressing the thyroid hormone axis. 1

  本发明涉及一种在哺乳动物中调节视黄醇X受体活性的方法，用于调节哺乳动物视黄醇X受体活性的新型化合物和制备这些化合物的方法。这些化合物由结构式I表示：结构式I的化合物是有效的胰岛素增敏剂，不具有增加甘油三酯或抑制甲状腺激素轴的不良副作用。1
• (PYRIDINYL AND PYRIMIDYL)TRIENOIC ACID DERIVATIVES AS RETINOID X RECEPTOR MODULATORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1414450A1

  公开（公告）日：2004-05-06
• [EN] (PYRIDINYL AND PYRIMIDYL) TRIENOIC ACID DERIVATIVES AS RETINOID X RECEPTOR MODULATORS<br/>[FR] DERIVES D'ACIDE TRIENOIQUE (PYRIDINYLE ET PYRIMIDYLE) AGISSANT COMME MODULATEURS DU RECEPTEUR RETINOIDE X
  申请人：LILLY CO ELI

  公开号：WO2003007950A1

  公开（公告）日：2003-01-30

  The present invention relates to a method of modulating retinoid X receptor activity in a mammal, novel compounds and pharmaceutical compositions for modulating retinoid X receptor activity in a mammal, and methods of making compounds that modulate retinoid X receptor activity in a mammal. The compounds are represented by Structural Formula I: The compounds of Structural Formula I are efficacious insulin sensitizers and do not have the undesirable side effects of increasing triglycerides or suppressing the thyroid hormone axis.