溴烯比妥 | 561-86-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 溴烯比妥
• 中文别名: 溴烯巴比妥；溴双丙烯比妥溴烯巴比妥；溴双丙烯比妥
• 英文名称: Brallobarbital
• 英文别名: 5-allyl-5-(2-bromo-allyl)-barbiturate；5-allyl-5-(2-bromo-allyl)-pyrimidine-2,4,6-trione；Brallobarbital, 5-Allyl-5-<2-brom-allyl>-barbitursaeure；5-Allyl-5-<2-brom-allyl>-barbitursaeure；5-(2-bromoprop-2-enyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
• CAS: 561-86-4
• 化学式: C₁₀H₁₁BrN₂O₃
• 分子量: 287.113
• InChiKey: DYODAJAEQDVYFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  75.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] S-NITROSOMERCAPTO COMPOUNDS AND RELATED DERIVATIVES<br/>[FR] COMPOSÉS DE S-NITROSOMERCAPTO ET DÉRIVÉS APPARENTÉS
  申请人：GALLEON PHARMACEUTICALS INC

  公开号：WO2009151744A1

  公开（公告）日：2009-12-17

  The present invention is directed to mercapto-based and S- nitrosomercapto-based SNO compounds and their derivatives, and their use in treating a lack of normal breathing control, including the treatment of apnea and hypoventilation associated with sleep, obesity, certain medicines and other medical conditions.

  本发明涉及基于巯基和S-亚硝基巯基的SNO化合物及其衍生物，以及它们在治疗正常呼吸控制缺失方面的用途，包括治疗与睡眠、肥胖、某些药物和其他医疗状况相关的呼吸暂停和低通气。
• Analgesic Compounds, Compositions, and Uses Thereof
  申请人：Mannion James C.

  公开号：US20110224269A1

  公开（公告）日：2011-09-15

  The invention relates to compounds, compositions, and methods for diminishing pain in a subject in need thereof comprising administering the compounds and compositions herein described.

  这项发明涉及化合物、组合物和方法，用于减轻需要的受试者的疼痛，包括给予所述的化合物和组合物。
• [EN] IMMUNOCONJUGATE SYNTHESIS METHOD<br/>[FR] PROCÉDÉ DE SYNTHÈSE D'IMMUNOCONJUGUÉ
  申请人：BOLT BIOTHERAPEUTICS INC

  公开号：WO2018191746A1

  公开（公告）日：2018-10-18

  A method for producing an immunoconjugate, the method comprising combining one or more compounds of Formula I and an antibody of Formula II, wherein Formula II is an antibody with one or more lysine residues, in an aqueous solution buffered at a pH of about 7.5 to about 9 until at least 33 mol% of the one or more compounds of Formula I is conjugated to the antibody of Formula II to provide the immunoconjugate of Formula III, wherein Adj is an adjuvant, Z is –CH2–, –C(O)NH–, –C(O)O–, or –C(O)–, L is a linker, E is an ester, and r is the average number of adjuvants attached to the antibody and is a positive number up to about 8, in a first buffered aqueous solution.

  一种制备免疫结合物的方法，所述方法包括将一种或多种I式化合物与II式抗体结合，其中II式抗体具有一种或多种赖氨酸残基，在pH约为7.5至9的缓冲水溶液中混合，直至至少33摩尔％的一种或多种I式化合物与II式抗体结合，以提供III式免疫结合物，其中Adj是一种佐剂，Z是-CH2-，-C(O)NH-，-C(O)O-或-C(O)-，L是一个连接物，E是一个酯，r是附着到抗体上的佐剂的平均数量，是一个正数，最多约为8，在第一个缓冲水溶液中。
• Nitric Oxide Releasing Prodrugs of Therapeutic Agents
  申请人：SATYAM Apparao

  公开号：US20110263526A1

  公开（公告）日：2011-10-27

  The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.

  本发明涉及已知药物或治疗剂的一氧化氮释放前药，其在此处表示为式(I)的化合物，其中药物或治疗剂包含一个或多个功能基团，独立地选自羧酸、氨基、羟基和巯基。该发明还涉及制备一氧化氮释放前药（式(I)的化合物）的方法，含有它们的药物组合物以及使用这些前药的方法。
• [EN] COMPOUNDS AND METHODS FOR TREATING ADDICTION AND RELATED DISORDERS<br/>[FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT D'UNE DÉPENDANCE ET DE TROUBLES ASSOCIÉS
  申请人：ASTROCYTE PHARMACEUTICALS INC

  公开号：WO2019157317A1

  公开（公告）日：2019-08-15

  The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example an addiction or compulsive disorder.

  本发明涉及化合物及其治疗某些疾病和症状的方法，例如成瘾或强迫性障碍。

表征谱图