溴焦酚红 | 16574-43-9

• 物质功能分类: 化学试剂 - 有机试剂 - 酚类
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 溴焦酚红
• 中文别名: 溴焦性没食子酸红；二溴邻苯三酚磺酞；溴邻苯三酚红
• 英文名称: bromopyrogallol red
• 英文别名: 2',7'-dibromo-1,1-dioxospiro[2,1λ6-benzoxathiole-3,9'-xanthene]-3',4',5',6'-tetrol
• CAS: 16574-43-9
• 化学式: C₁₉H₁₀Br₂O₈S
• 分子量: 558.158
• InChiKey: QFXYYBXMARTXHI-UHFFFAOYSA-N

物化性质

• 熔点：
  300 °C
• 沸点：
  681.2±55.0 °C(Predicted)
• 密度：
  2.39±0.1 g/cm3(Predicted)
• 蒸气密度：
  19.2 (vs air)
• 稳定性/保质期：
  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  30
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  142
• 氢给体数：
  4
• 氢受体数：
  8

安全信息

• TSCA：
  Yes
• 危险品标志：
  Xn
• 安全说明：
  S22,S24/25
• 危险类别码：
  R20/21/22
• 海关编码：
  32041900

制备方法与用途

化学性质
红棕色粉末状物质，熔点为300℃，能溶于醇中，溶液呈红色，并且微溶于水。

用途
主要用于分析试剂及络合滴定指示剂。此外，它还可作为钴、镍、钍、铌等金属的显色剂；同时也是稀土金属的络合滴定指示剂。

生产方法
由邻苯三酚红经溴化反应制得。具体步骤为：将邻苯三酚红悬浮于冰醋酸中，加热至沸，在搅拌下逐滴滴加溴的乙酸溶液。反应完成后冷却至室温，过滤去除游离溴，并用冰醋酸清洗。随后进行干燥处理，再以冰醋酸与丙酮的混合液进行重结晶，即可得到成品。

文献信息

• Inhibition of Shp2/PTPN11 Protein Tyrosine Phosphatase by NSC-87877, NSC-117199 and Their Analogs
  申请人：Wu Jie

  公开号：US20080176309A1

  公开（公告）日：2008-07-24

  Compounds and associated methods for inhibiting a protein tyrosine phosphatase. By a combination of experimental and virtual screenings of the NCI Diversity Set chemical library, NSC-87877 and NSC-117199 have been identified as Shp2 PTP inhibitors. Significantly, NSC-87877 is active in cell-based assays and has no detectable off-target effects in the EGF-stimulated Erk1/2 activation pathway. Additionally, a number of analogs of NSC-117199 have been produced. These analogs exhibit enhanced protein tyrosine phosphatase inhibition and are found to be potent and/or selective inhibitors of Shp1 and/or Shp2 protein tyrosine phosphatases.

  化合物及其相关方法，用于抑制蛋白酪氨酸磷酸酶。通过NCI Diversity Set化学库的实验和虚拟筛选的组合，已经确定NSC-87877和NSC-117199是Shp2 PTP抑制剂。值得注意的是，NSC-87877在基于细胞的实验中是活性的，并且在EGF刺激的Erk1/2激活途径中没有检测到任何非靶效应。此外，已经生产了许多NSC-117199的类似物。这些类似物表现出增强的蛋白酪氨酸磷酸酶抑制作用，并被发现是Shp1和/或Shp2蛋白酪氨酸磷酸酶的有效和/或选择性抑制剂。
• Methods for coating surfaces with antimicrobial agents
  申请人：The Board of Regents of the University of Texas System

  公开号：US10589003B2

  公开（公告）日：2020-03-17

  Disclosed are methods for coating or impregnating a surface with an antimicrobial agent that involve contacting the surface with a composition that includes an antimicrobial agent and a solvent, and curing the surface by applying heat. Also disclosed are methods for reducing the risk of development or progression of an infection in a subject in need of a medical device, that involve coating or impregnating a surface of the medical device with an antimicrobial agent and then curing the surface by applying heat, wherein the risk of development or progression of an infection is reduced.

  本发明公开了用抗菌剂涂覆或浸渍表面的方法，包括用包括抗菌剂和溶剂的组合物接触表面，并通过加热固化表面。还公开了降低需要使用医疗器械的受试者发生或恶化感染风险的方法，包括用抗菌剂涂覆或浸渍医疗器械表面，然后通过加热固化表面，从而降低发生或恶化感染的风险。
• COMPOSITION FOR SIMULTANEOUSLY LIGHTENING AND COLORING HAIR UTILIZING BLEACH-STABLE ACID AND BASIC DYES
  申请人：L'Avant Garde Inc.

  公开号：EP1372581A1

  公开（公告）日：2004-01-02
• EP1372581A4
  申请人：——

  公开号：EP1372581A4

  公开（公告）日：2005-04-20
• Methods for coating and impregnating medical devices with antiseptic compositions
  申请人：Raad Issam

  公开号：US20050197634A1

  公开（公告）日：2005-09-08

  The present invention provides methods of coating or impregnating medical devices with an antiseptic composition that will inhibit or prevent the nosocomial infections typically associated with the use of such medical devices. The present invention further provides methods of coating or impregnating medical devices that produce devices with effective activity against infection, while avoiding destroying the devices or causing the devices to become toxic. In addition, the invention provides medical devices coated or impregnated with antiseptic compositions by the aforementioned novel methods.

表征谱图