3,3-diphenyl-2-propen-1-amine | 5666-18-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3-diphenyl-2-propen-1-amine
• 英文别名: Diphenylpropenamine；3,3-diphenylprop-2-en-1-amine
• CAS: 5666-18-2
• 化学式: C₁₅H₁₅N
• 分子量: 209.291
• InChiKey: AXEZWCUFXPGSSA-UHFFFAOYSA-N

物化性质

• 沸点：
  360.0±37.0 °C(Predicted)
• 密度：
  1.043±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2921499090

反应信息

• 作为反应物：
  描述：

  3,3-diphenyl-2-propen-1-amine 在 水 、 potassium carbonate 作用下， 以 甲醇 、 乙醇 、 氯仿 、 丙酮 为溶剂， 反应 93.25h， 生成 N-(3,3-diphenylprop-2-enyl)-N'-<3-(imidazol-4-yl)propyl>guanidine
  参考文献：
  名称：

  Studies on histaminergic compounds VIII. A new series of compounds showing H1-antagonistic and H2-agonistic properties; synthesis, in vitro pharmacology and structure—activity relationships

  摘要：

  DOI：

  10.1016/0223-5234(87)90288-1
• 作为产物：
  描述：

  3-Amino-1,1-diphenyl-propanol-(1) 在 盐酸 、 溶剂黄146 作用下， 生成 3,3-diphenyl-2-propen-1-amine
  参考文献：
  名称：

  Adamson et al., Journal of the Chemical Society, 1949, p. Spl. 144, 152

  摘要：

  DOI：

文献信息

• Regioselective and Stereospecific Cross-Coupling of Primary Allylic Amines with Boronic Acids and Boronates through Palladium-Catalyzed CN Bond Cleavage
  作者：Man-Bo Li、Yong Wang、Shi-Kai Tian

  DOI：10.1002/anie.201109171

  日期：2012.3.19

  The NH2 group serves as an effective leaving group in the palladium‐catalyzed regioselective and stereospecific title reaction (see scheme). The reaction works well with aryl‐ and alkenylboronic acids and aryl‐, alkenyl‐, allyl‐, and benzylboronates, and complete transfer of chirality has been achieved when using α‐chiral primary allylic amines as the allylic electrophiles.

  NH 2 基团是钯催化的区域选择性和立体特异性标题反应中有效的离去基团（请参见方案）。该反应与芳基和烯基硼酸以及芳基，烯基，烯丙基和苄基硼酸酯反应良好，当使用α-手性伯烯丙基胺作为烯丙基亲电试剂时，已经实现了手性的完全转移。
• 2-(2,2-DIARYLETHYL)-CYCLIC AMINE DERIVATIVE OR SALT, SYNTHESIS THEREOF, AND APPLICATION AND COMPOSITION THEREOF
  申请人：DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES

  公开号：US20210155591A1

  公开（公告）日：2021-05-27

  The disclosure relates to a 2-(2,2-diarylethyl)-cyclic amine derivative or salt, a synthesis method, an application and a composition thereof. Biological activity test shows that this kind of 2-(2,2-diarylethyl)-cyclic amine derivative has good M-receptor antagonistic activity; and can be used as an active component of drugs for the treatment of the diseases mediated or regulated by muscarinic receptors, such as asthma, chronic obstructive pulmonary disease (COPD), overactive bladder (OAB), bronchospasm with chronic obstructive pulmonary disease, visceral spasm, irritable bowel syndrome, Parkinson's disease, depression or anxiety, schizophrenia and related mental diseases.

  本发明涉及一种2-(2,2-二芳基乙基)-环胺衍生物或盐，其合成方法、应用及组合物。生物活性测试显示，这类2-(2,2-二芳基乙基)-环胺衍生物具有优良的M受体拮抗活性；并且可以用作治疗由毒蕈碱受体介导或调节的疾病的药物中的活性成分，如哮喘、慢性阻塞性肺病（COPD）、过度活动膀胱（OAB）、慢性阻塞性肺病伴随的支气管痉挛、内脏痉挛、肠易激综合症、帕金森病、抑郁或焦虑、精神分裂症及相关精神疾病。
• Cascade reaction of propargylic alcohols with hydroxylamine hydrochloride: facile synthesis of α,β-unsaturated oximes and nitriles
  作者：Qi Zhang、Linjing Zhang、Chaojun Tang、Huan Luo、Xuediao Cai、Yonghai Chai

  DOI：10.1016/j.tet.2016.09.010

  日期：2016.11

  We have developed an easy and practical method for the synthesis of α,β-unsaturated oximes and nitriles from readily available propargylic alcohols with hydroxylamine hydrochloride (NH2OH·HCl) under metal-free conditions. By using or not using p-toluenesulfonyl chloride (p-TsCl) as the dehydrating promoter, the desired nitriles or oximes could be obtained, respectively via a three-step one-pot or two-step

  我们已经开发了一种简便实用的方法，可在无金属条件下，用容易得到的炔丙醇与盐酸羟胺（NH 2 OH·HCl）合成α，β-不饱和肟和腈。通过使用或不使用对甲苯磺酰氯（p -TsCl）作为脱水促进剂，可以分别通过三步一锅法或两步一锅法以中等至优异的产率获得所需的腈或肟。具有良好的功能组兼容性。
• Aminomethyltetrazoles as potential inhibitors of the γ-aminobutyric acid transporters mGAT1–mGAT4: Synthesis and biological evaluation
  作者：Eva S. Schaffert、Georg Höfner、Klaus T. Wanner

  DOI：10.1016/j.bmc.2011.08.039

  日期：2011.11

  1,5-Disubstituted and 5-monosubstituted aminomethyltetrazole derivatives derived from glycine were synthesized employing a TMSN3-modified variant of the Ugi reaction as a key step. All compounds were evaluated regarding their inhibitory potency and subtype selectivity at the four murine GABA transporter subtypes mGAT1–mGAT4. Though none of the 5-monosubstituted tetrazoles turned out to inhibit [3H]GABA

  以Ugi反应的TMSN 3修饰的变体为关键步骤，合成了衍生自甘氨酸的1，5-二取代和5-单取代的氨基甲基四唑衍生物。对所有化合物在四种鼠类GABA转运蛋白亚型mGAT1–mGAT4上的抑制力和亚型选择性进行了评估。尽管没有5取代的四唑类化合物能抑制[ 3H] GABA的吸收程度很高，1，5-二取代的四唑衍生物表现出独特的活性，尤其是在GABA转运蛋白mGAT2-mGAT4处。因此，发现了合理的有效和选择性的mGAT3抑制剂。另外，鉴定出另外两种化合物是mGAT2的有效抑制剂。这是特别相关的，因为到目前为止，只有很少几种不影响mGAT1的有效mGAT2抑制剂是已知的。
• [EN] 4-(METHYL SULFONYL AMINO) PHENYL ANALOGUES AS VANILLOID ANTAGONIST SHOWING EXCELLENT ANALGESIC ACTIVITY AND THE PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME<br/>[FR] ANALOGUES DE 4-(METHYL SULFONYL AMINO)PHENYLE UTILISES EN TANT QU'ANTAGONISTES DU RECEPTEUR VANILLOIDE AYANT UNE EXCELLENTE ACTIVITE ANALGESIQUE, ET COMPOSITIONS PHARMACEUTIQUE LES COMPRENANT
  申请人：DIGITALBIOTECH CO LTD

  公开号：WO2005003084A1

  公开（公告）日：2005-01-13

  The present invention relates to novel 4-(methylsulfonylamino) phenyl analogue as a potent vanilloid receptor antagonist and the pharmaceutical compositions comprising the same. The inventive compound can be useful for analgesics to prevent, alleviate or treat pain diseases or inflammatory disease comprising pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease, inflammatory disease and urgent urinary incontinence.

  本发明涉及一种新型的4-(甲磺胺基)苯基类似物，作为有效的辣椒素受体拮抗剂，以及包含该类似物的药物组合物。这种创新化合物可用于镇痛药，用于预防、缓解或治疗疼痛疾病或包括疼痛的炎症性疾病，如急性疼痛、慢性疼痛、神经痛、术后疼痛、偏头痛、关节痛、神经病、神经损伤、糖尿病性神经病、神经退行性疾病、神经性皮肤疾病、中风、膀胱过敏、肠易激综合征、哮喘或慢性阻塞性肺疾病等呼吸道疾病、皮肤、眼睛或粘膜的刺激、发热、胃十二指肠溃疡、炎症性肠病、炎症性疾病和急性尿失禁。