Tert-butyl 3-(2-methoxyprop-2-enyl)indole-1-carboxylate | 1007396-26-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Tert-butyl 3-(2-methoxyprop-2-enyl)indole-1-carboxylate
• CAS: 1007396-26-0
• 化学式: C₁₇H₂₁NO₃
• 分子量: 287.359
• InChiKey: DKXDHCZZHYRPIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  40.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Tert-butyl 3-(2-methoxyprop-2-enyl)indole-1-carboxylate 、 1,2,4,5-四嗪-3,6-二羧酸二甲酯 以 1,4-二氧六环 为溶剂， 反应 18.0h， 以31%的产率得到dimethyl 4-((1-(tert-butoxycarbonyl)-1H-indol-3-yl)methyl)pyridazine-3,6-dicarboxylate
  参考文献：
  名称：

  [EN] UPP AMPHIPHILIC ALPHA-HELIX MIMETICS
  [FR] MIMÉTIQUES AMPHIPHILES À HÉLICE ALPHA DE L'UPP

  摘要：

  公开号：

  WO2009020603A9
• 作为产物：
  描述：

  Tebbe's reagent 、 N-BOC-吲哚-3-乙酸甲酯 以 四氢呋喃 、 甲苯 为溶剂， 反应 2.5h， 生成 Tert-butyl 3-(2-methoxyprop-2-enyl)indole-1-carboxylate
  参考文献：
  名称：

  [EN] UPP AMPHIPHILIC ALPHA-HELIX MIMETICS
  [FR] MIMÉTIQUES AMPHIPHILES À HÉLICE ALPHA DE L'UPP

  摘要：

  公开号：

  WO2009020603A9

文献信息

• ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE
  申请人：Rebek, JR. Julius

  公开号：US20100022549A1

  公开（公告）日：2010-01-28

  The synthesis of new α-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available dimethyl pyridazine-3,6-dicarboxylate building block. These scaffolds may be thought of as synthetic counterparts of amphiphilic α-helices having a hydrophilic face along one side and a hydrophobic face along the other side of the helix.

  合成了模拟i、i+3或i+4、i+7残基的新α-螺旋支架。常见的吡啶嗪杂环来自易得的二甲基吡啶嗪-3,6-二甲酸二酯基块。这些支架可以被视为具有一个疏水面和一个疏水面的两侧的两性α-螺旋的合成对应物。
• OXAZOLE-PYRIDAZINE-OXAZOLE ALPHA-HELIX MIMETIC
  申请人：Rebek, JR. Julius

  公开号：US20100113466A1

  公开（公告）日：2010-05-06

  There are provided alpha helix scaffolds mimicking i, i+3/i+4, i+7 or i+11 residues having the general structure oxazole-pyridazine-piperidine or oxazole-pyridazine-oxazole. The common pyridazine heterocycle originates from substituted or unsubstituted dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate. These scaffolds are synthetic counterparts of amphiphilic alpha helices having a hydrophilic face along one side and a hydrophobic face along the other side of the helix.

  提供了模拟i，i+3/i+4，i+7或i+11残基的α螺旋支架，具有氧唑-吡啶嗪-哌啶或氧唑-吡啶嗪-氧唑的一般结构。常见的吡啶嗪杂环起源于取代或未取代的二甲基1,2,4,5-四氮唑-3,6-二羧酸酯。这些支架是具有亲水侧面和疏水侧面的两栖性α螺旋的合成对应物。
• Facile Synthesis of Pyridazine-Based a-Helix Mimetics
  作者：Julius Rebek、Lionel Moisan、Trevor J. Dale、Naran Gombosuren、Shannon M. Biros、Enrique Mann、Jun-Li Hou、Fernando P. Crisostomo

  DOI：10.3987/com-07-s(u)45

  日期：——
• [EN] ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE<br/>[FR] MIMÉTIQUE ALPHA HÉLICOÏDAL À PYRAZINE FONCTIONNALISÉE
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2010011864A2

  公开（公告）日：2010-01-28

  The synthesis of new α-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available dimethyl pyridazine-3,6-dicarboxylate building block. These scaffolds may be thought of as synthetic counterparts of amphiphilic ?-helices having a hydrophilic face along one side and a hydrophobic face along the other side of the helix.
• [EN] OXAZOLE-PYRIDAZINE-OXAZOLE ALPHA-HELIX MIMETIC<br/>[FR] MIMÉTIQUE DE TYPE HÉLICE ALPHA DE L'OXAZOLE-PYRIDAZINE-OXAZOLE
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2010042758A2

  公开（公告）日：2010-04-15

  There are provided alpha helix scaffolds mimicking i, i+3/i+4, i+7 or i+11 residues having the general structure oxazole-pyridazine-piperidine or oxazole-pyridazine-oxazole. The common pyridazine heterocycle originates from substituted or unsubstituted dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate. These scaffolds are synthetic counterparts of amphiphilic alpha helices having a hydrophilic face along one side and a hydrophobic face along the other side of the helix.