An Approach to the Bis-oxazole Macrocycle of Diazonamides
摘要:
A convergent approach to a macrocyclic compound embodying the complete "eastern" quadrant of diazonamides is described. The opening sequence in this work relies on an oxazole-forming reaction devised earlier in this group, while a late step involves a Robinson-Gabriel cyclization of an amidoketone to form a second oxazole.
A direct route to 2-alkyl-4-carbethoxy-5-vinyloxazoles
摘要:
The reaction of an alpha-chloroglycinate ester with the dimethylaluminum acetylide derivative of phenyl propargyl ether provides the corresponding 5-vinyloxazole in 40-50% yield. (C) 2010 Elsevier Ltd. All rights reserved.
Synthesis of 5-Amino-oxazole-4-carboxylates from α-Chloroglycinates
作者:Jianmin Zhang、Pierre-Yves Coqueron、Jean-Pierre Vors、Marco A. Ciufolini
DOI:10.1021/ol101704r
日期:2010.9.3
Aluminum-based Lewis acids are effective promoters of the condensation of alpha-chloroglycinates with isonitriles or with cyanide ion, leading to the formation of 5-amino-oxazoles.
An Approach to the Bis-oxazole Macrocycle of Diazonamides
作者:Jianmin Zhang、Marco A. Ciufolini
DOI:10.1021/ol102678j
日期:2011.2.4
A convergent approach to a macrocyclic compound embodying the complete "eastern" quadrant of diazonamides is described. The opening sequence in this work relies on an oxazole-forming reaction devised earlier in this group, while a late step involves a Robinson-Gabriel cyclization of an amidoketone to form a second oxazole.
A direct route to 2-alkyl-4-carbethoxy-5-vinyloxazoles
作者:Jianmin Zhang、Marco A. Ciufolini
DOI:10.1016/j.tetlet.2010.06.130
日期:2010.9
The reaction of an alpha-chloroglycinate ester with the dimethylaluminum acetylide derivative of phenyl propargyl ether provides the corresponding 5-vinyloxazole in 40-50% yield. (C) 2010 Elsevier Ltd. All rights reserved.