4,5-bis(4-dimethylaminophenyl)-1H-2-(2-pyridyl)imidazole | 1201275-38-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4,5-bis(4-dimethylaminophenyl)-1H-2-(2-pyridyl)imidazole
• 英文别名: 4-[4-[4-(dimethylamino)phenyl]-2-pyridin-2-yl-1H-imidazol-5-yl]-N,N-dimethylaniline
• CAS: 1201275-38-8
• 化学式: C₂₄H₂₅N₅
• 分子量: 383.496
• InChiKey: WXBBYUPKGPNTJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  48
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氰基吡啶 、 对二甲氨基苯甲醛 在 ammonium acetate 作用下， 反应 0.57h， 以80%的产率得到4,5-bis(4-dimethylaminophenyl)-1H-2-(2-pyridyl)imidazole
  参考文献：
  名称：

  Microwave Enabled Umpulong Mechanism Based Rapid and Efficient Four- and Six-Component Domino Formations of 2-(2′-Azaaryl)imidazoles and anti-1,2-Diarylethylbenzamides

  摘要：

  Concise and efficient six-component and four-component domino approaches to anti-1,2-diarylethylbenzamides and highly Substituted 2-(2'-azaaryl)imidazoles have been developed under solvent-free and microwave-irradiation conditions. The reactions showed a broad scope of substrates in which a wide range of common commercial aromatic aldehydes and heteroaryl nitriles can be used. The syntheses were Finished within short periods (15-34 min) with good to excellent chemical yields and stereoselectivity that avoided tedious workup isolations. New mechanisms involving an umpolung have been proposed for these two reaction processes.

  DOI：

  10.1021/jo902204s