(5Z)-5-[(4-hydroxyphenyl)methylidene]-2-methyl-3-(2H-triazol-4-ylmethyl)imidazol-4-one | 1360156-05-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (5Z)-5-[(4-hydroxyphenyl)methylidene]-2-methyl-3-(2H-triazol-4-ylmethyl)imidazol-4-one
• CAS: 1360156-05-3
• 化学式: C₁₄H₁₃N₅O₂
• 分子量: 283.29
• InChiKey: DZRXYVXAAAQRQW-MLPAPPSSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  94.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (Z)-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate 在 copper(ll) sulfate pentahydrate 、 水 、 potassium carbonate 、 sodium ascorbate 作用下， 以 乙醇 为溶剂， 反应 20.0h， 生成 (5Z)-5-[(4-hydroxyphenyl)methylidene]-2-methyl-3-(2H-triazol-4-ylmethyl)imidazol-4-one
  参考文献：
  名称：

  β-Cyclodextrin as a mimetic of the natural GFP-chromophore environment

  摘要：

  The green fluorescent protein (GFP) chromophore has been anchored to beta-cyclodextrin (beta CD) via a copper(I)-catalyzed azide-alkyne cycloaddition. The photophysical properties of this new GFP-CD derivative have been evaluated, showing the formation of a self-inclusion complex and enhancement of fluorescence of the GFP-chromophore covalently bound to the beta CD. This enhancement of fluorescence by encapsulation and hence fixation of the chromophore in a binding pocket mimics the effect exerted by the natural protein environment. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.053

文献信息

• β-Cyclodextrin as a mimetic of the natural GFP-chromophore environment
  作者：Martina Cacciarini、Mogens Brøndsted Nielsen、Elisa Martinez de Castro、Lavinia Marinescu、Mikael Bols

  DOI：10.1016/j.tetlet.2011.12.053

  日期：2012.2

  The green fluorescent protein (GFP) chromophore has been anchored to beta-cyclodextrin (beta CD) via a copper(I)-catalyzed azide-alkyne cycloaddition. The photophysical properties of this new GFP-CD derivative have been evaluated, showing the formation of a self-inclusion complex and enhancement of fluorescence of the GFP-chromophore covalently bound to the beta CD. This enhancement of fluorescence by encapsulation and hence fixation of the chromophore in a binding pocket mimics the effect exerted by the natural protein environment. (C) 2011 Elsevier Ltd. All rights reserved.