3-hydroxy-5-butyloxy-benzyl alcohol | 350035-56-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-hydroxy-5-butyloxy-benzyl alcohol
• 英文别名: 3-Butoxy-5-hydroxybenzenemethanol；3-butoxy-5-(hydroxymethyl)phenol
• CAS: 350035-56-2
• 化学式: C₁₁H₁₆O₃
• 分子量: 196.246
• InChiKey: LXUKIJIOKJLQRO-UHFFFAOYSA-N

物化性质

• 沸点：
  371.7±27.0 °C(Predicted)
• 密度：
  1.120±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxy-5-butyloxy-benzyl alcohol 在 18-冠醚-6 、 四溴化碳 、 potassium carbonate 、 三苯基膦 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 39.0h， 生成 4-Bromomethyl-6-butoxy-3',5'-bis-(3-butoxy-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-biphenyl
  参考文献：
  名称：

  Toward Globular Macromolecules with Functionalized Interiors:  Design and Synthesis of Dendrons with an Interesting Twist

  摘要：

  [GRAPHCIS]Design and synthesis of a novel class of monodendrons, in which the functional units can potentially be directed toward the concave interiors of dendrimers, are described. The key feature of the design is the placement of the amphiphilic and the AB(2) functional groups in orthogonal planes.

  DOI：

  10.1021/ol016064b
• 作为产物：
  描述：

  1-碘丁烷 、 3,5-二羟基苯甲醇 在 18-冠醚-6 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 以54%的产率得到3-hydroxy-5-butyloxy-benzyl alcohol
  参考文献：
  名称：

  Toward Globular Macromolecules with Functionalized Interiors:  Design and Synthesis of Dendrons with an Interesting Twist

  摘要：

  [GRAPHCIS]Design and synthesis of a novel class of monodendrons, in which the functional units can potentially be directed toward the concave interiors of dendrimers, are described. The key feature of the design is the placement of the amphiphilic and the AB(2) functional groups in orthogonal planes.

  DOI：

  10.1021/ol016064b

文献信息

• Invertible amphiphilic polymers
  申请人：Thayumanavan Sankaran

  公开号：US20070293669A1

  公开（公告）日：2007-12-20

  Amphiphilic monomeric compounds and corresponding homopolymers and copolymers capable of assembly and invertible configuration in introduction to and change in fluid medium.

  具有两性单体化合物及相应的同聚物和共聚物能够在流体介质中进行组装和可逆配置。
• Homopolymer Micelles in Heterogeneous Solvent Mixtures
  作者：Subhadeep Basu、Dharma Rao Vutukuri、S. Thayumanavan

  DOI：10.1021/ja056042a

  日期：2005.12.1

  Amphiphilic homopolymers containing a hydrophilic and a hydrophobic functionality in each monomer unit have been shown to form polar or apolar containers depending on the solvent environment. When presented with a mixture of solvents, these polymeric containers are capable of releasing certain guest molecules. The fundamental mechanism behind these properties is investigated, and the utility of these assemblies in separations has been demonstrated with an example.
• US7507840B2
  申请人：——

  公开号：US7507840B2

  公开（公告）日：2009-03-24
• US7687600B2
  申请人：——

  公开号：US7687600B2

  公开（公告）日：2010-03-30
• [EN] BIARYL MONOMERS AND DENDRITIC POLYMERS DERIVED THEREFROM<br/>[FR] MONOMERES BIARYLES ET POLYMERES DENDRITIQUES DERIVES
  申请人：UNIV TULANE

  公开号：WO2002077037A2

  公开（公告）日：2002-10-03

  Globular dendritic polymers having functional groups oriented on the exterior and interior surfaces of the polymer are disclosed (Fig 1). The inventive polymers are composed of biaryl monomer units having at least two substituents. One of the substituents orients toward the exterior surface of the globular dendritic polymer and the other substituent orients toward the interior surface of the polymer. Each substituent can be selected to have an affinity for a solvent having a particular solvent property, such as, for example, hydrophobicity, hydrophilicity, solvent polarity, pH, ionic strength. When the polymer is dissolved in a solvent having a solvent having a solvent parameter for which a substituent has an affinity, that substituent orients toward the external surface of the polymer. When one substituent is hydrophilic and one substituent is hydrophobic, the polymers are facially amphiphilic. The dendeitic polymers are useful for encapsulation and controlled release of phamraceutical and agrochemical agents, catalysis, and targeted drug delivery.