N-acetylmannosamine-6-phosphate | 7433-20-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-acetylmannosamine-6-phosphate
• 英文别名: N-Acetylmannosamin-6-phosphorsaeure；aldehydo-N-acetyl-D-mannosamine 6-phosphate；[(2R,3S,4R,5S)-5-acetamido-2,3,4-trihydroxy-6-oxohexyl] dihydrogen phosphate
• CAS: 7433-20-7
• 化学式: C₈H₁₆NO₉P
• 分子量: 301.19
• InChiKey: QDSLHWJDSQGPEE-WCTZXXKLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  174
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• ENGINEERED INTRACELLULAR SIALYLATION PATHWAYS
  申请人：THE UNIVERSITY OF WYOMING

  公开号：US20140024812A1

  公开（公告）日：2014-01-23

  Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins.

  提供了一种操作感兴趣细胞中碳水化合物处理途径的方法。该方法旨在通过利用重组DNA技术和底物供应方法来操纵与唾液酸化反应有关的多个途径，从而使感兴趣细胞中产生唾液酸化糖蛋白。这些碳水化合物工程努力包括实施新的碳水化合物生物测定方法，检查一系列昆虫细胞系，并利用生物信息学来鉴定关键处理酶的基因序列。这些组成部分包括产生唾液酸化糖蛋白的感兴趣细胞。这些方法和组成物对于异源表达糖蛋白非常有用。
• Detection of endometrial secretion markers for assesment of endometriosis
  申请人：LABORATORIOS S.A.L.V.A.T., S.A.

  公开号：EP2065707A1

  公开（公告）日：2009-06-03

  The present invention refers to a group of biomarkers and to non-invasive in vitro methods for the diagnosis or prognosis of endometriosis, as well as to a kit to perform said methods.

  本发明涉及一组生物标志物和用于诊断或预后子宫内膜异位症的非侵入性体外方法，以及用于执行上述方法的试剂盒。
• Combination vaccines with whole cell pertussis antigen
  申请人：Novartis Vaccines and Diagnostics S.r.l.

  公开号：EP2206515A1

  公开（公告）日：2010-07-14

  Vaccines have been studied that comprise (a) D-T-Pw-HepB-Hib antigens and (b) one or more meningococcal conjugate antigens. A number of improvements and variations of these vaccines have been discovered. The vaccines can be prepared extemporaneously at the time of use by mixing together two components: (a) a first component comprising D, T, wP and HBsAg antigens; and (b) a second component comprising a Hib conjugate and one or more meningococcal conjugates.

  研究的疫苗包括 (a) D-T-Pw-HepB-Hib 抗原和 (b) 一种或多种脑膜炎球菌结合抗原。已经发现了这些疫苗的许多改进和变体。疫苗可在使用时通过将两种成分混合在一起即刻制备：(a) 由 D、T、wP 和 HBsAg 抗原组成的第一种成分；以及 (b) 由 Hib 结合体和一种或多种脑膜炎球菌结合体组成的第二种成分。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• Method of engineering a cytidine monophosphate-sialic acid synthetic pathway in fungi and yeast
  申请人：GlycoFi, Inc.

  公开号：EP2365089A1

  公开（公告）日：2011-09-14

  The present invention provides methods for generating CMP-sialic acid in a non-human host which lacks endogenous CMP-Sialic by providing the host with enzymes involved in CMP-sialic acid synthesis from a bacterial, mammalian or hybrid CMP-sialic acid biosynthetic pathway. Novel fungal hosts expressing a CMP-sialic acid biosynthetic pathway for the production of sialylated glycoproteins are also provided.

  本发明提供了在缺乏内源性 CMP-Sialic的非人类宿主中生成 CMP-sialic酸的方法，方法是为宿主提供参与 CMP-sialic酸合成的酶，这些酶来自细菌、哺乳动物或杂交 CMP-sialic酸生物合成途径。此外，还提供了表达 CMP-ialic酸生物合成途径的新型真菌宿主，用于生产苷元化糖蛋白。