2-(3-(1-phenyl-tetrazol-5-ylthio)propyl)-1H-isoindole-1,3(2H)-dione | 933873-52-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(3-(1-phenyl-tetrazol-5-ylthio)propyl)-1H-isoindole-1,3(2H)-dione
• 英文别名: 2-[3-(1-Phenyltetrazol-5-yl)sulfanylpropyl]isoindole-1,3-dione
• CAS: 933873-52-0
• 化学式: C₁₈H₁₅N₅O₂S
• 分子量: 365.415
• InChiKey: ZKEUMPWZDNTNRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  106
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(3-(1-phenyl-tetrazol-5-ylthio)propyl)-1H-isoindole-1,3(2H)-dione 在 肼 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 生成 3-(1-phenyl-1H-tetrazol-5-yl-thio)propan-1-amine
  参考文献：
  名称：

  Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains

  摘要：

  A novel series of ketolides with 11,12-sulfur contained aryl alkyl side chains were synthesized and evaluated for their antibacterial activity. These ketolides exhibited potent activity against key macrolide sensitive and resistant respiratory pathogens. The newly synthesized 9a, 9e, 9k and 9n showed a similar antimicrobial spectrum and comparable activity to telithromycin, the commercial ketolide antibacterial. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.11.004
• 作为产物：
  描述：

  N-(3-溴丙基)苯二胺 、 1-苯基-5-巯基四氮唑 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以88%的产率得到2-(3-(1-phenyl-tetrazol-5-ylthio)propyl)-1H-isoindole-1,3(2H)-dione
  参考文献：
  名称：

  Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains

  摘要：

  A novel series of ketolides with 11,12-sulfur contained aryl alkyl side chains were synthesized and evaluated for their antibacterial activity. These ketolides exhibited potent activity against key macrolide sensitive and resistant respiratory pathogens. The newly synthesized 9a, 9e, 9k and 9n showed a similar antimicrobial spectrum and comparable activity to telithromycin, the commercial ketolide antibacterial. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.11.004