1-Formyl-1-propyl-cyclohexan | 103649-07-6

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机氧化物
• 英文名称: 1-Formyl-1-propyl-cyclohexan
• 英文别名: 1-propyl-cyclohexanecarbaldehyde；1-Propyl-cyclohexancarbaldehyd；1-Propyl-cyclohexanecarbaldehyde；1-propylcyclohexane-1-carbaldehyde
• CAS: 103649-07-6
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: DKJIWXITRCKDOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Formyl-1-propyl-cyclohexan 在 硫酸 、 苯 作用下， 生成 1-环己基-1-丁酮
  参考文献：
  名称：

  Preparation of Sunstituted 4-Pentenals

  摘要：

  DOI：

  10.1021/ja01522a057
• 作为产物：
  描述：

  (1-Propyl-cyclohexyl)-methanol 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 生成 1-Formyl-1-propyl-cyclohexan
  参考文献：
  名称：

  Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives

  摘要：

  Design and synthesis of an EP2-receptor selective agonist began with the chemical modification of alpha- and omega-chains of butaprost 1a, which exhibits an affinity for the IP-receptor. Two series of prostaglandin (PG) analogues with a 16-hydroxy-17,17-trimethylene moiety as an omega-chain were identified. Among those tested, 4a,b,e,f,h and 6a,b,e,f,h were found to be highly selective EP2-receptor agonists. Structure activity relationships are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00369-8

文献信息

• Radical Carbonyl Propargylation by Dual Catalysis
  作者：Huan‐Ming Huang、Peter Bellotti、Constantin G. Daniliuc、Frank Glorius

  DOI：10.1002/anie.202011996

  日期：2021.2

  Carbonyl propargylation has been established as a valuable tool in the realm of carbon–carbon bond forming reactions. The 1,3‐enyne moiety has been recognized as an alternative pronucleophile in the above transformation through an ionic mechanism. Herein, we report for the first time, the radical carbonyl propargylation through dual chromium/photoredox catalysis. A library of valuable homopropargylic

  羰基炔丙基化已被确立为碳-碳键形成反应领域中的一种宝贵工具。在上述通过离子机理的转化中，1,3-烯炔部分被认为是另一种亲核试剂。在此，我们首次报道了通过双重铬/光氧化还原催化的羰基羰基化。通过1,3-炔烃，醛和合适的自由基前体的催化自由基三组分偶联，可以获得带有全碳季中心的有价值的均丙醇的库（41个实例）。这种氧化还原中性的多组分反应在非常温和的条件下发生，显示出很高的官能团耐受性。十分稳定，无毒且价格便宜的CrCl 3可以用作铬源。初步的机械研究表明，自由基-极性交叉机制为从简单化学物质制备有价值的合成结构提供了一种补充和新颖的方法。
• Weiss,F. et al., Bulletin de la Societe Chimique de France, 1966, p. 1149 - 1150
  作者：Weiss,F. et al.

  DOI：——

  日期：——
• α,α-Cyclobisalkylation of aldehydes via ω-haloaldimines
  作者：Christian V. Stevens、Norbert G. De Kimpe、Alan R. Katritzky

  DOI：10.1016/s0040-4039(00)73093-0

  日期：1994.5

  The construction of a cycloalkyl ring at the alpha-position of aldehydes by cyclization of omega-haloaldimines is described. Alkylation of the corresponding aldimines with alpha,omega-dihaloalkanes followed by treatment with LDA results in a convenient access to alpha,alpha-cyclobisalkylated aldimines which are hydrolyzed to the alpha,alpha-cycloalkylaldehydes.
• Preparation of Sunstituted 4-Pentenals
  作者：Kent C. Brannock

  DOI：10.1021/ja01522a057

  日期：1959.7
• Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives
  作者：Kousuke Tani、Atsushi Naganawa、Akiharu Ishida、Kenji Sagawa、Hiroyuki Harada、Mikio Ogawa、Takayuki Maruyama、Shuichi Ohuchida、Hisao Nakai、Kigen Kondo、Masaaki Toda

  DOI：10.1016/s0968-0896(01)00369-8

  日期：2002.4

  Design and synthesis of an EP2-receptor selective agonist began with the chemical modification of alpha- and omega-chains of butaprost 1a, which exhibits an affinity for the IP-receptor. Two series of prostaglandin (PG) analogues with a 16-hydroxy-17,17-trimethylene moiety as an omega-chain were identified. Among those tested, 4a,b,e,f,h and 6a,b,e,f,h were found to be highly selective EP2-receptor agonists. Structure activity relationships are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.