2-(N-乙酰氧基-N-乙酰氨基)菲 | 26541-57-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 中文名称: 2-(N-乙酰氧基-N-乙酰氨基)菲
• 英文名称: N-Acetoxy-2-acetamidophenanthren
• 英文别名: N-acetoxy-N-2-phenanthrylacetamide；N-acetoxyacetylaminophenanthrene；N-Acetoxy-2-acetylaminophenanthrene；[acetyl(phenanthren-2-yl)amino] acetate
• CAS: 26541-57-1
• 化学式: C₁₈H₁₅NO₃
• 分子量: 293.322
• InChiKey: PBUJMRDTXSUQHF-UHFFFAOYSA-N

物化性质

• 沸点：
  435.17°C (rough estimate)
• 密度：
  1.2278 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2924299090

制备方法与用途

类别：有毒物品

可燃性危险特性：

• 可燃；
• 加热分解会释放有毒氮氧化物烟雾。

储运特性：

• 应存放在通风、低温和干燥的库房内。

灭火剂：

• 干粉、泡沫、砂土、二氧化碳或雾状水均可用于灭火。

反应信息

• 作为反应物：
  描述：

  2-(N-乙酰氧基-N-乙酰氨基)菲 以 硝基苯 为溶剂， 生成 2-Acetylamino-phenanthryl-acetat
  参考文献：
  名称：

  The synthesis and reactions of some carcinogenic N-(2-Phenanthryl)hydroxylamine derivatives

  摘要：

  报告了 2-nitrophenanthrene 的合成。一些 2-取代菲和 9,l0-二氢菲的 羟胺衍生物，并确定了重排产物的结构。 重排产物的结构。

  DOI：

  10.1071/ch9741791

文献信息

• Multi-stage stem cell carcinogenesis
  申请人：Krtolica Ana

  公开号：US20100162416A1

  公开（公告）日：2010-06-24

  The present invention relates to a system of multi-stage stem cell carcinogenesis and a method of generating such multi-stage stem cell carcinogenesis system. Various stages of cancer stem cells can be generated from normal stem cells via mutagenesis. The system of the present invention enables monitoring changes in the ability of cells to transition from one stage of carcinogenesis to another and to identify genetic pathways and molecules that influence carcinogenesis. The present invention also enables a high-throughput and nonbiased screening for targets that preferentially affect cancer stem cells relative to non-cancer stem cells or their derivatives during stem cell carcinogenesis, thus is useful in developing anti-cancer therapeutics.
• [EN] MULTI-STAGE STEM CELL CARCINOGENESIS<br/>[FR] CARCINOGENESE DE CELLULES SOUCHES MULTIETAPES
  申请人：STEMLIFELINE INC

  公开号：WO2010037134A2

  公开（公告）日：2010-04-01

  The present invention relates to a system of multi-stage stem cell carcinogenesis and a method of generating such multi-stage stem cell carcinogenesis system. Various stages of cancer stem cells can be generated from normal stem cells via mutagenesis. The system of the present invention enables monitoring changes in the ability of cells to transition from one stage of carcinogenesis to another and to identify genetic pathways and molecules that influence carcinogenesis. The present invention also enables a high-throughput and nonbiased screening for targets that preferentially affect cancer stem cells relative to non-cancer stem cells or their derivatives during stem cell carcinogenesis, thus is useful in developing anti-cancer therapeutics.