2-(N-甲基乙酰氨基)乙酸乙酯 | 34597-05-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-(N-甲基乙酰氨基)乙酸乙酯
• 英文名称: N-acetyl-N-methyl-glycine ethyl ester
• 英文别名: N-Acetyl-sarkosin-aethylester；(Methyl-acetyl-amino)-essigsaeure-aethylester；N-Acetyl-N-methyl-glycin-aethylester；Ethyl 2-(N-methylacetamido)acetate；ethyl 2-[acetyl(methyl)amino]acetate
• CAS: 34597-05-2
• 化学式: C₇H₁₃NO₃
• 分子量: 159.185
• InChiKey: CLDAJCQRVCXYIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  2-(N-甲基乙酰氨基)乙酸乙酯 生成 2-(acetyl-methyl-amino)-3-oxo-propionic acid ethyl ester
  参考文献：
  名称：

  Brown, Chemistry of Penicillin

  摘要：

  DOI：
• 作为产物：
  描述：

  溴乙酸乙酯 、 N-甲基-N-(三甲基硅基)乙酰胺 生成 2-(N-甲基乙酰氨基)乙酸乙酯
  参考文献：
  名称：

  Kricheldorf,H.R.; Greber,G., Chemische Berichte, 1971, vol. 104, p. 3131 - 3145

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS<br/>[FR] COMPOSÉS DE CYCLOPROPYLE SUBSTITUÉS UTILES À TITRE D'AGONISTES DE GPR119
  申请人：MERCK SHARP & DOHME

  公开号：WO2013074388A1

  公开（公告）日：2013-05-23

  Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included

  公开了公式（I）的环丙基化合物及其药学上可接受的盐，用于治疗或预防2型糖尿病和类似疾病。这些化合物可作为G蛋白偶联受体GPR-119的激动剂。还包括药物组合物和治疗方法。
• Structure dependence in the solvolysis kinetics of amino acid esters
  作者：John Haseltine、Jason W. Runyon

  DOI：10.1016/j.tetlet.2010.04.063

  日期：2010.6

  To better understand acyl transfer reactions of oligopeptides, seventeen N-acyl amino acid esters were solvolyzed in mildly basic methanol-d4. All show pseudo-first-order kinetics by 1H NMR. The rate constant varies up to 400-fold with the identity of the amino acid and up to 6200-fold with the identity of the N-acyl group. The impact of the N-acyl group on the rate constant is discussed in terms of

  为了更好地理解寡肽的酰基转移反应，在温和的碱性甲醇-d 4中溶剂化了十七种N-酰基氨基酸酯。通过1 H NMR均显示拟一级动力学。速率常数随氨基酸的同一性而变化多达400倍，而随着N-酰基的同一性而变化高达6200倍。根据拥挤，酰胺构象和酰胺CO键特征讨论了N-酰基对速率常数的影响。
• COMPOSITION, ARTIFICIAL NAIL COMPOSITION, NAIL DECORATION MATERIAL, ARTIFICIAL NAIL, STORED CONTAINER, IMAGE FORMING APPARATUS, AND IMAGE FORMING METHOD
  申请人：Suenaga Takenori

  公开号：US20200038309A1

  公开（公告）日：2020-02-06

  Provided is a composition including: an acrylamide compound represented by general formula (1) in 20% by mass or greater but 50% by mass or less; a multifunctional monomer in 40% by mass or greater but 70% by mass or less; and a polymerization initiator, where in general formula (1), R 1 represents alkyl group containing 1 through 6 carbon atoms, X represents alkylene group containing 1 through 6 carbon atoms, and Y represents any one selected from the group consisting of general formula (2) below and general formula (3) below, where in general formula (2), R 2 represents alkyl group containing 1 through 10 carbon atoms, and * represents binding site with X above, where in general formula (3), R 2 represents alkyl group containing 1 through 10 carbon atoms, and * represents binding site with X above.

  提供的是一种组合物，包括：质量分数为20%或更高但不超过50%的一种由一般式（1）表示的丙烯酰胺化合物；质量分数为40%或更高但不超过70%的多功能单体；以及聚合引发剂。其中，在一般式（1）中，R1表示含有1至6个碳原子的烷基基团，X表示含有1至6个碳原子的亚烷基基团，Y表示从以下公式（2）和以下公式（3）组成的群中任选一种。在一般式（2）中，R2表示含有1至10个碳原子的烷基基团，“*”表示与上述X结合的结合位点。在一般式（3）中，R2表示含有1至10个碳原子的烷基基团，“*”表示与上述X结合的结合位点。
• Propylene polymer catalyst donor component
  申请人：Uhrhammer Roger

  公开号：US20080125614A1

  公开（公告）日：2008-05-29

  A solid, hydrocarbon-insoluble, catalyst component useful in polymerizing olefins containing magnesium, titanium, and halogen further contains an internal electron donor comprising a compound containing electron donating substituents with a structure: wherein D 1 and D 2 are selected individually from and R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 individually are hydrocarbon or substituted hydrocarbon groups containing 1 to 20 carbon atoms and R 1 , R 2 , R 3 , R 4 , R 6 , and R 7 may be hydrogen; R 4 may be —NR 2 ; and wherein groups R 1 and R 2 , R 2 and R 3 , R 3 and R 4 , R 3 and R 5 , and groups R 6 and R 7 may be joined to form a cyclic structure.

  一种固体、烃类不溶性催化剂组分，可用于聚合含有镁、钛和卤素的烯烃，进一步包含一种内部电子给体，其包含一种具有以下结构的电子给体取代基的化合物：其中D1和D2分别选自和，R、R1、R2、R3、R4、R5、R6和R7分别为含有1至20个碳原子的烃基或取代烃基，其中R1、R2、R3、R4、R6和R7可以是氢；R4可以是—NR2；以及其中R1和R2、R2和R3、R3和R4、R3和R5以及R6和R7可以连接成环状结构。
• Pyrazole derivative
  申请人：Kanaya Naoaki

  公开号：US20060128685A1

  公开（公告）日：2006-06-15

  The present invention is directed to a strong platelet aggregation-inhibiting agent which does not inhibit COX-1 or COX-2. The present invention provides compounds represented by formula (I) or formula (II), salts of the compounds, and solvates of the compounds or the salts. Also provided are medicaments containing any of the compounds, salts, or solvates and preventive and/or therapeutic agents for ischemic diseases, containing any of the compounds, salts, or the solvates.

  本发明旨在提供一种强的血小板聚集抑制剂，其不抑制COX-1或COX-2。本发明提供了由式（I）或式（II）表示的化合物，化合物的盐以及化合物或盐的溶剂。还提供了包含任何一种化合物、盐或溶剂的药物以及预防和/或治疗缺血性疾病的制剂，其中包含任何一种化合物、盐或溶剂。