1-decanesulfonic acid | 20283-21-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 1-decanesulfonic acid
• 英文别名: Decane-1-sulfonic acid
• CAS: 20283-21-0
• 化学式: C₁₀H₂₂O₃S
• mdl: MFCD25960776
• 分子量: 222.349
• InChiKey: KVGOXGQSTGQXDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 1-decanesulfonic acid 生成 1-decanesulfonic acid methyl ester
  参考文献：
  名称：

  The chemistry of terpenes—VIII

  摘要：

  DOI：

  10.1016/0040-4020(78)80050-7
• 作为产物：
  描述：

  正癸烯 在 甲醇 、 ammonium hydrogen sulfite 、 过氧化苯甲酸叔丁酯 作用下， 生成 1-decanesulfonic acid
  参考文献：
  名称：

  DE819995

  摘要：

  公开号：

文献信息

• [EN] MODULATORS OF DOPAMINE NEUROTRANSMISSION<br/>[FR] MODULATEURS DE LA NEUROTRANSMISSION DE LA DOPAMINE
  申请人：NSAB AF NEUROSEARCH SWEDEN AB

  公开号：WO2009133109A1

  公开（公告）日：2009-11-05

  The present invention relates to novel 1-(2,3-dihydro-1,4-benzodioxin-2-yl)-methanamine derivatives, useful as modulators of dopamine neurotransmission, and more specifically as dopaminergic stabilizers. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

  这项发明涉及新颖的1-(2,3-二氢-1,4-苯并二氧杂环戊烷-2-基)-甲胺衍生物，用作多巴胺神经传导调节剂，更具体地用作多巴胺稳定剂。在其他方面，该发明涉及将这些化合物用于治疗方法以及包括该发明化合物的药物组合物。
• [EN] NOVEL 1 -ALKYL- 3 -HYDROXY- 3 -PHENYLAZETIDINE DERIVATIVES USEFUL AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION<br/>[FR] NOUVEAUX DÉRIVÉS DE 1-ALKYL-3-HYDROXY-3-PHÉNYLAZÉTIDINE UTILES EN TANT QUE MODULATEURS DE LA NEUROTRANSMISSION CATÉCHOLAMINERGIQUE CORTICALE
  申请人：NSAB AF NEUROSEARCH SWEDEN AB

  公开号：WO2010058020A1

  公开（公告）日：2010-05-27

  The present invention relates to novel 3-phenyl-azetidine derivatives, useful for modulating dopamine neurotransmission and extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically for the treatment of central nervous system disorders. In other aspects the invention relates to pharmaceutical compositions comprising the 3-phenyl-azetidine derivatives of the invention and to the use of these compounds for therapeutic applications. X is OH; R1 is F or Cl; R2 is H, F or Cl; and R3 is n-Pr, i-Pr, n-Bu, i-Bu, s-Bu or t-Bu.

  本发明涉及新型3-苯基-氮杂环丙烷衍生物，用于调节哺乳动物大脑的大脑皮层区域中多巴胺神经传导和儿茶酚胺、多巴胺和去甲肾上腺素的细胞外水平，更具体地用于治疗中枢神经系统疾病。在其他方面，本发明涉及包含本发明的3-苯基-氮杂环丙烷衍生物的药物组合物以及利用这些化合物进行治疗应用。X为OH；R1为F或Cl；R2为H、F或Cl；R3为n-Pr、i-Pr、n-Bu、i-Bu、s-Bu或t-Bu。
• NOVEL 1-ALKYL-3-HYDROXY-3-PHENYLAZETIDINE DERIVATIVES USEFUL AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION
  申请人：Sonesson Clas

  公开号：US20110257148A1

  公开（公告）日：2011-10-20

  The present invention relates to novel 3-phenyl-azetidine derivatives, useful for modulating dopamine neurotransmission and extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically for the treatment of central nervous system disorders. In other aspects the invention relates to pharmaceutical compositions comprising the 3-phenyl-azetidine derivatives of the invention and to the use of these compounds for therapeutic applications. X is OH; R 1 is F or Cl; R 2 is H, F or Cl; and R 3 is n-Pr, i-Pr, n-Bu, i-Bu, s-Bu or t-Bu.

  本发明涉及新颖的3-苯基-氮杂环丙烷衍生物，用于调节哺乳动物大脑的脑皮层区域中多巴胺神经传递和儿茶酚胺、多巴胺和去甲肾上腺素的细胞外水平，更具体地用于治疗中枢神经系统疾病。在其他方面，本发明涉及包含本发明的3-苯基-氮杂环丙烷衍生物的药物组合物，以及利用这些化合物进行治疗应用。其中，X为OH；R1为F或Cl；R2为H、F或Cl；R3为n-Pr、i-Pr、n-Bu、i-Bu、s-Bu或t-Bu。
• Colorant compounds
  申请人：Banning H. Jeffrey

  公开号：US20060020141A1

  公开（公告）日：2006-01-26

  Compounds of the formula wherein M is either (1) a metal ion having a positive charge of +y wherein y is an integer which is at least 2, said metal ion being capable of forming a compound with at least two chromogen moieties, or (2) a metal-containing moiety capable of forming a compound with at least two chromogen moieties, z is an integer representing the number of chromogen moieties associated with the metal and is at least 2, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , a, b, c, d, Y, and z are as defined herein, Q − is a COO − group or a SO 3 — group, A is an organic anion, and CA is either a hydrogen atom or a cation associated with all but one of the Q − groups.

  式中的化合物，其中M是一个带有正电荷+y的金属离子，其中y是至少为2的整数，该金属离子能够与至少两个色团基团形成化合物，或者M是一个含金属基团的基团，能够与至少两个色团基团形成化合物，z是表示与金属相关的色团基团数量的整数，至少为2，R1、R2、R3、R4、R5、R6、R7、a、b、c、d、Y和z的定义如上所述，Q-是一个COO-基团或SO3-基团，A是一个有机阴离子，CA是一个氢原子或与除一个Q-基团之外的所有Q-基团相关联的阳离子。
• PROCESS FOR PRODUCING AMINOALKYLSULFONIC ACID AND METHOD OF SALT EXCHANGE FOR SALT THEREOF
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：EP1548002A1

  公开（公告）日：2005-06-29

  The present invention relates to a method for efficiently producing an aminoalkylsulfonic acid in an industrial scale, and provides    "a process for producing an aminoalkylsulfonic acid represented by the general formula [2]:    wherein R1 and R2 are each independently a hydrogen atom, an alkyl group, an aryl group or an aralkyl group; and R3 and R4 are each independently a hydrogen atom or an alkyl group, comprising reacting an aminoalkylsulfonate salt represented by the general formula [1]:    wherein M is an alkali metal atom, an organic ammonium ion or an ammonium ion; and R1 to R4 are the same as described above,    an aqueous solution thereof, or a solution dissolving any one of them in a water-soluble organic solvent, selected from alcohols having 1 to 3 carbon atoms, carboxylic acids having 2 to 12 carbon atoms and dimethylformamide, with an organic acid; and    a method of salt exchange for an aminoalkylsulfonate salt represented by the general formula [1']:    wherein M' is an alkali metal atom, an organic ammonium ion or an ammonium ion; and R1 and R4 are the same as described above, comprising reacting an aminoalkylsulfonate salt represented by the above general formula [2] with a hydroxide represented by the general formula [6]:         M'OH     [6]    wherein M' is the same as described above, in an alcohol or water".

  本发明涉及一种在工业规模上高效生产氨基磺酸的方法，并提供“一种生产由通式[2]表示的氨基磺酸的方法：其中R1和R2分别是氢原子、烷基、芳基或芳基烷基；R3和R4分别是氢原子或烷基的氨基磺酸盐发生反应所得的方法，通式[1]表示如下：其中M是碱金属原子、有机铵离子或铵离子；R1至R4与上述相同，其水溶液或将任何一种溶解于水溶性有机溶剂中的溶液，所选的有1至3个碳原子的醇、有2至12个碳原子的羧酸和二甲基甲酰胺，与有机酸反应；以及氨基磺酸盐交换的方法，通式[1']表示如下：其中M'是碱金属原子、有机铵离子或铵离子；R1和R4与上述相同，包括将上述通式[2]表示的氨基磺酸盐与通式[6]表示的氢氧化物发生反应：M'OH [6]其中M'与上述相同，在醇或水中”。