1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)ethanone | 59942-89-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)ethanone
• 英文别名: 1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)ethanone
• CAS: 59942-89-1
• 化学式: C₁₂H₁₄N₂O
• 分子量: 202.25
• InChiKey: HSVNIJDFSGCUCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  34.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-异丙基吡唑并[1,5-a]吡啶 、 乙酸酐 在 硫酸 sodium hydroxide 、 乙酸乙酯 、 Sodium sulfate-III 、 crude material 、 silica gel 、 hexanes 作用下， 以 ice water 为溶剂， 反应 3.0h， 以to give 11.8 g (87%) of 1-(2-isopropyl-pyrazolo[1,5-a]pyridin-3-yl)-ethanone的产率得到1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)ethanone
  参考文献：
  名称：

  Substituted pyrazolo[1,5-a]pyridine compounds and their methods of use

  摘要：

  本发明涉及取代的吡唑并[1,5-a]吡啶及其合成和使用的相关方法。

  公开号：

  US07585875B2

文献信息

• Substituted pyrazolo [1,5-a] pyridine compounds and their methods of use
  申请人：Gaeta C.A. Federico

  公开号：US20080070912A1

  公开（公告）日：2008-03-20

  The present invention is directed to substituted pyrazolo[1,5-α]pyridines and related methods for their synthesis and use.

  本发明涉及取代的吡唑并[1,5-α]吡啶及其合成和使用的相关方法。
• Novel pyrazolo [1,5-a]pyridines
  申请人：Kyorin Pharmaceutical Co., Ltd.

  公开号：US04028370A1

  公开（公告）日：1977-06-07

  The present invention provides substituted pyrazolo[1,5-a]pyridine derivatives expressed by a compound of the general formula (I), ##STR1## (wherein: X is hydrogen atom or methyl group; R is hydrogen atom, straight or branched lower alkyl group, lower alkoxy group, lower alkylthio group, dialkylamino group, alkyleneimino group, and morpholino group; R.sub.1 is different from R and is hydrogen atom, straight or branched lower alkyl group, lower alkoxy alkyl group, and dialkylamino group). The compound of the present invention can be prepared by reacting a compound of the general formula (II), ##STR2## in which X and R are as shown hereinbefore, with a compound of the general formula (III), in which R.sub.1 is as shown hereinbefore, R.sub.1 COOH (III) or with a functional derivative of the compound of the general formula (III).

  本发明提供了一种通式（I）表示的取代吡唑并[1,5-a]吡啶衍生物，其中：X为氢原子或甲基基团；R为氢原子、直链或支链低碳基基团、低碳基氧基团、低碳基硫基团、二碳基基氨基团、烷基亚氨基团和吗啉基团；R1不同于R，为氢原子、直链或支链低碳基基团、低碳基氧基烷基团和二碳基基氨基团。本发明的化合物可通过将通式（II）表示的化合物与通式（III）表示的化合物反应制备而成，其中X和R如上所示，R1如上所示，R1为COOH（III）或通式（III）的功能衍生物。
• Pyrazolo\x9b1,5-a!pyridines \n'
  申请人：Kyorin Pharmaceutical Co., Ltd.

  公开号：US04097483A1

  公开（公告）日：1978-06-27

  The present invention provides substituted pyrazolo\x9b1,5-a!pyridine \n' derivatives expressed by a compound of the general formula (I), ##STR1## (wherein: X is hydrogen atom or methyl group; R is hydrogen atom, straight or branched lower alkyl group, lower alkoxy group, lower alkylthio group, dialkylamino group, alkyleneimino group, and morpholino group; R.sub.1 is different from R and is hydrogen atom, straight or branched lower alkyl group, lower alkoxy alkyl group, and dialkylamino group). The compound of the present invention can be prepared by reacting a compound of the general formula (II), ##STR2## in which X and R are as shown hereinbefore, with a compound of the general formula (III), in which R.sub.1 is as shown hereinbefore, R.sub.1 COOH (III) or with a functional derivative of the compound of the general formula (III).

  本发明提供了由通式（I）的化合物表达的取代的吡唑并[1,5-a]吡啶衍生物，其中：X为氢原子或甲基基团；R为氢原子、直链或支链低级烷基基团、低级烷氧基基团、低级烷基硫基团、二烷基氨基基团、烷基亚氨基基团和吗啉基团；R1与R不同，为氢原子、直链或支链低级烷基基团、低级烷氧基烷基基团和二烷基氨基基团。本发明的化合物可通过将通式（II）的化合物与通式（III）的化合物反应制备而成，其中X和R如上所示，R1如上所示，R1为COOH或通式（III）的官能衍生物。
• Substituted pyrazolo[1,5-a]pyridine compounds and their methods of use
  申请人：Avigen, Inc.

  公开号：US07585875B2

  公开（公告）日：2009-09-08

  The present invention is directed to substituted pyrazolo[1,5-a]pyridines and related methods for their synthesis and use.

  本发明涉及取代的吡唑并[1,5-a]吡啶及其合成和使用的相关方法。
• Ameliorating composition for dysmnesia
  申请人：KYORIN SEIYAKU KABUSHIKI KAISHA

  公开号：EP0368343A2

  公开（公告）日：1990-05-16

  An ameliorating composition for dysmnesia, comprising as an active ingredient at least one pyrazolo[1,5-a]pyridine derivative represented by the general formula: wherein R¹ and R² are independently hydrogen or a lower alkyl of 1 - 4 carbons, R³ is hydrogen or a lower alkyl of 1 - 3 carbons or a lower alkoxy of 1 - 3 carbons.

  一种改善失忆症的组合物，其活性成分包括至少一种由通式表示的吡唑并[1,5-a]吡啶衍生物： 其中 R¹ 和 R² 独立地为氢或 1 - 4 个碳原子的低级烷基，R³ 为氢或 1 - 3 个碳原子的低级烷基或 1 - 3 个碳原子的低级烷氧基。