5-(4-bromomethyl-phenyl)-2-methyl-2H-tetrazole | 38446-69-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(4-bromomethyl-phenyl)-2-methyl-2H-tetrazole
• 英文别名: 5-[4-(bromomethyl)phenyl]-2-methyl-1,2,3,4-tetraazole；5-[4-(bromomethyl)phenyl]-2-methyl-1,2,3,4-tetrazole；4-(2-methyl-2H-tetrazol-5-yl)phenylmethyl bromide；5-(4-Bromomethylphenyl)-2-methyl-2H-tetrazole；5-[4-(bromomethyl)phenyl]-2-methyltetrazole
• CAS: 38446-69-4
• 化学式: C₉H₉BrN₄
• 分子量: 253.101
• InChiKey: GZTBEQFZDQNDBM-UHFFFAOYSA-N

物化性质

• 沸点：
  384.6±44.0 °C(Predicted)
• 密度：
  1.61±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(4-bromomethyl-phenyl)-2-methyl-2H-tetrazole 、 4-氧代哌啶酮盐酸盐 在 N,N-二异丙基乙胺 作用下， 以 二甲基亚砜 为溶剂， 反应 72.0h， 生成 1-([4-(2-methyl-1,2,3,4-tetrazol-5-yl)phenyl]methyl)piperidin-4-one
  参考文献：
  名称：

  [EN] N-SUBSTITUTED AZACYCLES
  [FR] AZACYCLES N-SUBSTITUES

  摘要：

  公开号：

  WO2005036961A3
• 作为产物：
  描述：

  2-methyl-5-(p-tolyl)-2H-tetrazole 在 过氧化苯甲酰 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氯化碳 为溶剂， 反应 3.5h， 生成 5-(4-bromomethyl-phenyl)-2-methyl-2H-tetrazole
  参考文献：
  名称：

  [EN] N-SUBSTITUTED AZACYCLES
  [FR] AZACYCLES N-SUBSTITUES

  摘要：

  公开号：

  WO2005036961A3

文献信息

• Insecticidal n-(substituted arylmethyl)-4-[bis(substituted phenyl) methyl]p
  申请人：FMC Corporation

  公开号：US05569664A1

  公开（公告）日：1996-10-29

  Compounds of the following structure, the corresponding N-oxides and agriculturally acceptable salts, are disclosed as effective insecticides: ##STR1## in which U is selected from ##STR2## Q is selected from hydrogen, hydroxy, sulfhydryl, and fluorine; R is selected from a heterocycle having 5 or 6 ring atoms, optionally fused to a benzene ring, and ##STR3## wherein V, W, X, Y, Z are as defined in the specification.

  以下结构化合物，对应的N-氧化物和农业可接受的盐，被披露为有效的杀虫剂：##STR1## 其中U从##STR2## 中选择，Q从氢、羟基、硫醇和氟中选择；R从具有5个或6个环原子的杂环中选择，可选地融合到苯环和##STR3## 中选择，其中V、W、X、Y、Z如规范中定义。
• Insecticidal N-(substituted arylmethyl)-4-[bis(substituted
  申请人：FMC Corporation

  公开号：US05639763A1

  公开（公告）日：1997-06-17

  Compounds of the following structure, the corresponding N-oxides and agriculturally acceptable salts, are disclosed as effective insecticides: ##STR1## in which U is selected from --(CH.sub.2).sub.n -- and ethylidene; Q is selected from hydrogen, hydroxy, sulfhydryl, and fluorine; R is ##STR2## in which V is selected from hydrogen, halogen, alkyl, haloalkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsilyloxy, dialkylamino, cyano, nitro, hydroxy, and phenyl; Y and Z are independently selected from hydrogen and alkoxy; W and X taken together is --OCH.sub.2 CH.sub.2 O--, --CH.sub.2 C(CH.sub.3).sub.2 O--, --OC(CH.sub.3).sub.2 O--, or --N.dbd.C(C.sub.2 H.sub.5)O--; R.sup.1 and R.sup.2 are independently selected from phenyl substituted with halogen, alkyl, haloalkyl, haloalkoxy, alkoxyalkyl, hydroxy, arylthio, alkoxy, dialkylamino, dialkylaminosulfonyl, hydroxyalkylaminocarbonyl, alkylsulfonyloxy, and haloalkylsulfonyloxy; and n is 1, 2, or 3.

  公开了具有以下结构的化合物，相应的N-氧化物和农业可接受的盐作为有效的杀虫剂：##STR1## 其中U从--(CH.sub.2).sub.n--和乙烯基中选择；Q从氢、羟基、硫醇和氟中选择；R从##STR2## 中选择，其中V从氢、卤素、烷基、卤代烷基、烷氧基、烷基硫基、烷基亚砜基、烷基硅氧基、二烷基氨基、氰基、硝基、羟基和苯基中选择；Y和Z独立地从氢和烷氧基中选择；W和X结合在一起是--OCH.sub.2 CH.sub.2 O--，--CH.sub.2 C(CH.sub.3).sub.2 O--，--OC(CH.sub.3).sub.2 O--或--N.dbd.C(C.sub.2 H.sub.5)O--；R.sup.1和R.sup.2独立地从用卤素、烷基、卤代烷基、卤代烷氧基、烷氧基烷基、羟基、芳基硫基、烷氧基、二烷基氨基、二烷基氨基磺酰基、羟基烷基氨基羰基、烷基砜氧基和卤代烷基砜氧基取代的苯基中选择；n为1、2或3。
• [EN] N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL) PIPERIDINES AND PYRIDINES<br/>[FR] N-(ARYLMETHYL SUBSTITUE)-4-(METHYL DISUBSTITUE) PIPERIDINES ET PYRIDINES ASSOCIEES
  申请人：FMC CORP

  公开号：WO2004060371A1

  公开（公告）日：2004-07-22

  It has now been found that certain novel N-(substituted aryl)-4(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected fronn 0 or 1 ; and p is 0, 1, 2, or 3; A is C or CH; and B, D, E, R, R1, R2, R3, R4, R5, R6, R7 and R8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  现在已经发现，某些新型的N-(取代芳基)-4(二取代甲基)哌啶和吡啶衍生物具有意想不到的杀虫活性。这些化合物由公式(I)表示：其中m、n、q、r和s分别独立地从0或1中选择；p为0、1、2或3；A为C或CH；B、D、E、R、R1、R2、R3、R4、R5、R6、R7和R8在此处均有完整描述。此外，还披露了包含公式I中至少一种化合物的杀虫有效量的组合物，以及可选地含有至少一种第二化合物的有效量，其中至少一种杀虫兼容载体；以及控制昆虫的方法，包括将上述组合物应用于昆虫存在或预计存在的地点。
• Sulfonamide compounds for the treatment of neurodegenerative disorders
  申请人：Brodney A. Michael

  公开号：US20050222254A1

  公开（公告）日：2005-10-06

  The present invention relates to compounds of the Formula I wherein R 1 , R 2 , R 3 , m, and n are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-peptide. The invention also relates to pharmaceutical compositions and methods for treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.

  本发明涉及公式I中的化合物，其中R1、R2、R3、m和n如所定义。公式I的化合物具有抑制Aβ-肽产生活性。本发明还涉及含有公式I化合物的药物组合物和治疗疾病和疾病的方法，例如，神经退行性和/或神经系统疾病，例如阿尔茨海默病，在哺乳动物中。
• N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines
  申请人：Ding Ping

  公开号：US20060135504A1

  公开（公告）日：2006-06-22

  It has now been found that certain novel N-(substituted aryl)-4(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected from 0 or 1; and p is 0, 1, 2, or 3; A is C or CH; and B, D, E, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  现已发现某些新型N-(取代芳基)-4(二取代甲基)哌啶和吡啶衍生物具有出乎意料的杀虫活性。这些化合物由式(I)表示：其中m、n、q、r和s独立地选自0或1；p为0、1、2或3；A为C或CH；B、D、E、R、R1、R2、R3、R4、R5、R6、R7和R8在此完整描述。此外，还公开了包含式(I)中至少一种化合物的杀虫有效量和可选的第二种化合物的有效量，以及至少一种杀虫兼容载体的组合物；以及控制昆虫的方法，包括将所述组合物应用于昆虫存在或预计存在的地点。