2-α-(benzyloxycarbonyl)-glycinyl)-amino>-benzophenone | 106849-44-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-α-(benzyloxycarbonyl)-glycinyl)-amino>-benzophenone
• 英文别名: 2-α-(benzyloxycarbonyl)glicynyl)amino>benzophenone；2-N-(α-Isopropylthio-N-benzyloxycarbonylglycinyl)aminobenzophenone；2-{N-[α-(isopropylthio)-N^α-(benzyloxycarbonyl)-glycinyl]-amino}-benzophenone；2-[N-(alpha-(Isopropylthio)-N-(benzyloxycarbonyl)-glycinyl)amino]benzophenone；benzyl N-[2-(2-benzoylanilino)-2-oxo-1-propan-2-ylsulfanylethyl]carbamate
• CAS: 106849-44-9
• 化学式: C₂₆H₂₆N₂O₄S
• 分子量: 462.569
• InChiKey: NDECXFVTCVUMRZ-UHFFFAOYSA-N

物化性质

• 沸点：
  686.7±55.0 °C(Predicted)
• 密度：
  1.247±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-α-(benzyloxycarbonyl)-glycinyl)-amino>-benzophenone 在 palladium on activated charcoal 甲酸 、 ammonium acetate 、 氨 、 mercury dichloride 作用下， 以 四氢呋喃 、 甲醇 、 溶剂黄146 为溶剂， 反应 8.5h， 生成 3-氨基-5-苯基-1,3-二氢-2H-1,4-苯并二氮杂革-2-酮
  参考文献：
  名称：

  Synthesis and resolution of 3-amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-ones

  摘要：

  DOI：

  10.1021/jo00391a010
• 作为产物：
  描述：

  氨基甲酸苄酯 在 N-甲基吗啉 、 氯甲酸异丁酯 作用下， 反应 12.25h， 生成 2-α-(benzyloxycarbonyl)-glycinyl)-amino>-benzophenone
  参考文献：
  名称：

  An expedient synthesis of 3-amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one

  摘要：

  DOI：

  10.1016/s0040-4039(00)95879-9

文献信息

• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：——

  公开号：US20020045747A1

  公开（公告）日：2002-04-18

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  公开了抑制β-淀粉样肽释放和/或其合成的化合物，因此可用于治疗阿尔茨海默病。还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这些药物组合物预防性和治疗性治疗阿尔茨海默病的方法。
• Process for 3-acylamino benzodiazepines
  申请人：Merck & Co., Inc.

  公开号：US04628084A1

  公开（公告）日：1986-12-09

  The present invention provides an improved process for producing 3-acylamino benzodiazepines of the formula: ##STR1## wherein: R is loweralkyl of from 1-6 carbon atoms, aryl such as phenyl and halophenyl, aralkyl, alkyloxy, aralkyloxy, indolyl or substituted indolyl; R' is hydrogen, loweralkyl of from 1-6 carbon atoms, carboxymethyl or carbalkoxymethyl wherein the alkoxy groups contain from 1-4 carbon atoms; X is hydrogen or halogen; Y is hydrogen or halogen. These compounds are useful because of their activity as cholecystokinin (CCK) inhibitors.

  本发明提供了一种改进的方法，用于生产公式为：##STR1## 的3-酰胺基苯二氮平衍生物，其中：R是1-6个碳原子的低碳基，如苯基和卤苯基，芳基烷基，烷氧基，芳基烷氧基，吲哚基或取代吲哚基；R'是氢，1-6个碳原子的低碳基，羧甲基或卡巴洛甲氧基，其中烷氧基含有1-4个碳原子；X是氢或卤素；Y是氢或卤素。这些化合物因其作为胆囊收缩素（CCK）抑制剂的活性而有用。
• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting B-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：——

  公开号：US20020173504A1

  公开（公告）日：2002-11-21

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明涉及抑制&bgr;-淀粉样肽的释放和/或合成的化合物，因此具有治疗阿尔茨海默病的效用。还公开了包含抑制&bgr;-淀粉样肽释放和/或合成的化合物的药物组合物，以及使用这种药物组合物预防和治疗阿尔茨海默病的方法。
• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-Amyloid peptide release and/or its synthesis by use of such compounds
  申请人：——

  公开号：US20020111343A1

  公开（公告）日：2002-08-15

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明涉及一种抑制β-淀粉样肽释放和/或合成的化合物，因此具有治疗阿尔茨海默病的效用。本发明还涉及包含抑制β-淀粉样肽释放和/或合成的化合物的制药组合物，以及使用这种制药组合物预防和治疗阿尔茨海默病的方法。
• Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：——

  公开号：US20030130188A1

  公开（公告）日：2003-07-10

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明揭示了一些化合物，可以抑制&bgr;-淀粉样肽的释放和/或合成，因此在治疗阿尔茨海默病方面具有实用性。本发明还揭示了包含抑制&bgr;-淀粉样肽释放和/或合成的化合物的制药组合物，以及使用这些制药组合物预防和治疗阿尔茨海默病的方法。