1H,3'H-2,4'-Biimidazole | 144648-45-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1H,3'H-2,4'-Biimidazole
• 英文别名: 2-(1H-imidazol-5-yl)-1H-imidazole
• CAS: 144648-45-3
• 化学式: C₆H₆N₄
• 分子量: 134.14
• InChiKey: XWHKSDHUFQIWQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.4
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Methods for inhibiting deacetylase activity
  申请人：Bedaloy Antonio

  公开号：US20050079995A1

  公开（公告）日：2005-04-14

  A method for identifying a compound that inhibits the NAD + -dependent deacetylase activity of a SIR2 protein is disclosed. These compounds are useful for the treatment of cancers and other diseases, through the activation of silenced genes, through the promotion of apoptosis in cancerous cells, and through the inhibition of transcriptional repressor activity in oncogenes.

  揭示了一种用于识别抑制SIR2蛋白的NAD+-依赖性去乙酰化酶活性的化合物的方法。这些化合物通过激活沉默基因、促进癌细胞凋亡以及抑制癌基因转录抑制因子活性，对治疗癌症和其他疾病有用。
• PQS: A NEW HYDROTROPE FOR SOLUBILIZING LIPOPHILIC COMPOUNDS IN WATER
  申请人：Lipshutz H. Bruce

  公开号：US20070208088A1

  公开（公告）日：2007-09-06

  The present invention provides a solubilizing agent of the general formula: wherein R 11 , R 12 and R 13 are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl. L1 and L2 are linker moieties, which are members independently selected from substituted or unsubstituted alkyl and substituted or unsubstituted heteroalkyl. Y1 and Y2 are hydrophilic moieties, which are members independently selected from polyethers, polyalcohols and derivatives thereof. Z1, Z2, Z3 and Z4 are members independently selected from 0 and 1, wherein at least one of Z1 and Z2 is 1.

  本发明提供了一种通式为的溶解剂剂：其中，R11、R12和R13分别是H、取代或未取代的烷基、取代或未取代的杂烷基、取代或未取代的环烷基、取代或未取代的杂环烷基、取代或未取代的芳基和取代或未取代的杂芳基中的独立成员。L1和L2是连接基，分别是取代或未取代的烷基和取代或未取代的杂烷基中的独立成员。Y1和Y2是亲水性基团，分别是聚醚、多元醇及其衍生物中的独立成员。Z1、Z2、Z3和Z4是独立选择的成员0和1，其中至少一个Z1和Z2为1。
• Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases
  申请人：——

  公开号：US20040162318A1

  公开（公告）日：2004-08-19

  The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.

  本发明涉及新型苯并呋喃衍生物和类似物，以及含有它们的组合物，以及将它们用于治疗或预防与病毒感染有关的疾病，特别是由丙型肝炎病毒引起的病毒感染和相关疾病的用途。
• IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS
  申请人：Bodmer Vera Q.

  公开号：US20130018039A1

  公开（公告）日：2013-01-17

  Disclosed are compounds having the formula: wherein R 1A , R 1B , R 2 and R 3 are defined herein, and methods of making and using the same.

  本发明涉及具有以下式的化合物：其中R1A，R1B，R2和R3如本文所定义，并且涉及其制备和使用的方法。
• INSECTICIDAL N-(HETEROARYLALKYL) ALKANEDIAMINE DERIVATIVES
  申请人：FMC CORPORATION

  公开号：EP1689231A2

  公开（公告）日：2006-08-16