5-(2,4-Dimethyl-phenyl)-oxazole | 243455-54-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(2,4-Dimethyl-phenyl)-oxazole
• 英文别名: 5-(2,4-Dimethylphenyl)oxazole；5-(2,4-dimethylphenyl)-1,3-oxazole
• CAS: 243455-54-1
• 化学式: C₁₁H₁₁NO
• 分子量: 173.214
• InChiKey: IURMPDFUUFVEQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,4-二甲基苯甲醛 、 alkaline earth salt of/the/ methylsulfuric acid 在 四丁基氢氧化铵 作用下， 以 甲醇 、 乙二醇二甲醚 为溶剂， 以42%的产率得到5-(2,4-Dimethyl-phenyl)-oxazole
  参考文献：
  名称：

  A solid-phase equivalent of van Leusen's TosMIC, and its application in oxazole synthesis

  摘要：

  Polystyrene-SH resin, prepared from Merrifield resin in two steps, was converted to polystyrene-SO2-CH2-NC in three steps. This resin functions as a solid-phase equivalent of p-tolylsulfonylmethyl isocyanide (TosMIC). Thus, reaction with aromatic aldehydes and tetrabutylammonium hydroxide as base yields 5-aryloxazoles. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01049-7

文献信息

• Solution-phase parallel oxazole synthesis with TosMIC
  作者：Bheemashankar A. Kulkarni、A. Ganesan

  DOI：10.1016/s0040-4039(99)01050-3

  日期：1999.7

  A quaternary ammonium hydroxide ion exchange resin catalyzes the reaction of p-tolylsulfonylmethyl isocyanide (TosMIC) with aromatic aldehydes to give 5-aryloxazoles. The base and the p-tolylsulfinic acid byproduct are removed by simple filtration, resulting in oxazoles in high yield and purity.

  季铵氢氧化物离子交换树脂催化对甲苯磺酰基甲基异氰酸酯（TosMIC）与芳族醛的反应，生成5-芳基恶唑。通过简单的过滤除去碱和对甲苯基亚磺酸副产物，从而以高收率和纯度得到恶唑。
• A solid-phase equivalent of van Leusen's TosMIC, and its application in oxazole synthesis
  作者：Bheemashankar A. Kulkarni、A. Ganesan

  DOI：10.1016/s0040-4039(99)01049-7

  日期：1999.7

  Polystyrene-SH resin, prepared from Merrifield resin in two steps, was converted to polystyrene-SO2-CH2-NC in three steps. This resin functions as a solid-phase equivalent of p-tolylsulfonylmethyl isocyanide (TosMIC). Thus, reaction with aromatic aldehydes and tetrabutylammonium hydroxide as base yields 5-aryloxazoles. (C) 1999 Elsevier Science Ltd. All rights reserved.