Palladium-Catalyzed Regioselective Synthesis of 3-Arylindoles from <i>N</i>
-Ts-Anilines and Styrenes
作者:So Won Youn、Tae Yun Ko、Young Ho Jang
DOI:10.1002/anie.201702205
日期:2017.6.1
A Pd-catalyzed intermolecular oxidative annulation between N-Ts-anilines and styrenes was developed. This method offers a straightforward and robust approach to a wide range of 3-arylindoles using readily available starting materials with good functional-group tolerance and high regioselectivity and efficiency. Further elaboration of the products obtained from this process provided access to highly
A Tandem Cross-Coupling/S<sub>N</sub>Ar Approach to Functionalized Carbazoles
作者:David J. St. Jean,、Steve F. Poon、Jamie L. Schwarzbach
DOI:10.1021/ol702274y
日期:2007.11.1
A novel route to functionalized carbazoles utilizing a tandem Suzuki cross-coupling/SNAr protocol is described. This process was found to be compatible with a variety of electron-withdrawing groups including aldehydes, esters, and sulfones. Using this method, a concise total synthesis (four steps, 50% overall yield) of the carbazole alkaloid glycosinine was achieved.
Facile one-pot synthesis of 2-aminoindoles from simple anilines and ynamides
作者:Young Ho Kim、Huen Ji Yoo、So Won Youn
DOI:10.1039/d0cc06490d
日期:——
A highly effective and straightforward one-potsynthesis of diversely substituted 2-aminoindoles has been developed, involving sequential Au(I)-catalyzed regioselective hydroamination and CuCl2-mediated oxidative cyclization. This protocol offers an operationally easy, simple, robust, and sustainable approach with the use of readily available starting materials, good functional group tolerance, and
Electrocatalytic Dehydrogenative Cyclization of 2-Vinylanilides for the Synthesis of Indoles
作者:Yun-Tao Zheng、Jinshuai Song、Hai-Chao Xu
DOI:10.1021/acs.joc.1c00988
日期:2021.11.19
Indole is prevalent in bioactive compounds and natural products. The development of efficient and sustainable methods to access this privileged structural scaffold has been a long-standing interest of synthetic chemists. Herein, we report an electrocatalytic method for the synthesis of indoles through dehydrogenative cyclization of 2-vinylanilides. The reactions employ an organic redox catalyst and
Cu-Catalyzed Arylation/Acyl Migration Cascade Reaction of Enaminones: Access to N-Fused Polycyclic and 2,3-Disubstituted Indoles
作者:Weishuang Li、Zhan Dong、Yan Zhang、Zhen Zeng、Muhammad Usman、Wen-Bo Liu
DOI:10.1021/acs.joc.9b00866
日期:2019.6.21
polycyclic and 2,3-disubstitutedindoles by copper-catalyzed direct annulation/acyl migration reaction of enaminones is reported. This strategy features cheap and low loading of the catalyst/ligand, readily available starting materials, and good functional group compatibilities. Notably, allyl-containing substrates are also tolerated, which allows the downstream derivatization toward indole alkaloids.