2-(2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinyl)-4-(2,4-dichlorophenyl)thiazole | 1334025-48-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinyl)-4-(2,4-dichlorophenyl)thiazole
• 英文别名: 4-(2,4-dichlorophenyl)-N-[[1-[(2,4-dichlorophenyl)methyl]indol-3-yl]methylideneamino]-1,3-thiazol-2-amine
• CAS: 1334025-48-7
• 化学式: C₂₅H₁₆Cl₄N₄S
• 分子量: 546.307
• InChiKey: LTXYCTBYNFAEEA-UHFFFAOYSA-N

物化性质

• 熔点：
  185 °C
• 沸点：
  710.0±70.0 °C(predicted)
• 密度：
  1.48±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  70.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4-二氯苯乙酮 在 aluminum (III) chloride 、 溴 、 三乙胺 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 0.5h， 生成 2-(2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinyl)-4-(2,4-dichlorophenyl)thiazole
  参考文献：
  名称：

  Synthesis and biological evaluation of substituted 4-arylthiazol-2-amino derivatives as potent growth inhibitors of replicating Mycobacterium tuberculosis H37RV

  摘要：

  In search of potential therapeutics for tuberculosis, we describe herein synthesis and biological evaluation of some substituted 4-arylthiazol-2-amino derivatives as modified analogues of the antiprotozoal drug Nitazoxanide (NTZ), which has recently been reported as potent inhibitor of Mtb H(37)Rv (Mtb MIC = 52.12 mu M) with an excellent ability to evade resistance. Among the synthesized derivatives, the two compounds 7a ( MIC = 15.28 mu M) and 7c (MIC = 17.03 mu M) have exhibited about three times better Mtb growth inhibitory activity over NTZ and are free from any cytotoxicity (Vero CC50 of 244 and 300 mu M respectively). These two compounds represent promising leads for further optimization. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.06.076

文献信息

• [EN] SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF<br/>[FR] 4-ARYLTHIAZOLES SUBSTITUÉS ET PROCÉDÉ DE PRÉPARATION DE CES DERNIERS
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2012164572A1

  公开（公告）日：2012-12-06

  The present invention relates to novel substituted 4-arylthiazoles, their preparation, and to their use as therapeutic agents, particularly in the prevention or treatment of tuberculosis. The resent invention articularl relates to com ounds of formula A:

  本发明涉及新型取代的4-芳基噻唑化合物，其制备以及作为治疗剂的用途，特别是在预防或治疗结核病方面。该发明特别涉及公式A的化合物。
• SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF
  申请人：Singh Supriya

  公开号：US20140235863A1

  公开（公告）日：2014-08-21

  The present invention relates to novel substituted 4-arylthiazoles, their preparation, and to their use as therapeutic agents, particularly in the prevention or treatment of tuberculosis. The present invention particularly relates to compounds of formula A:

  本发明涉及新型取代的4-芳基噻唑，其制备方法，以及其作为治疗剂的用途，特别是在结核病的预防或治疗方面。本发明特别涉及A式化合物。