5-ethylthiazole | 17626-73-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-ethylthiazole
• 英文别名: 5-ethyl-thiazole；5-Aethyl-thiazol；5-Aethylthiazol；5-Ethyl-thiazol；5-Ethylthiazol；5-ethyl-1,3-thiazole
• CAS: 17626-73-2
• 化学式: C₅H₇NS
• 分子量: 113.183
• InChiKey: ASAMCDOTLOUAAR-UHFFFAOYSA-N

物化性质

• 沸点：
  162.9±9.0 °C(Predicted)
• 密度：
  1.078±0.06 g/cm3(Predicted)
• LogP：
  1.249 (est)
• 保留指数：
  914;917;914;917

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-ethylthiazole 在 氘氧化钠 、 四丁基溴化铵 作用下， 以 氘代苯 为溶剂， 反应 3.0h， 生成 2-deuterio-5-ethyl-thiazole
  参考文献：
  名称：

  噻唑中的氢-氘交换通过相转移催化

  摘要：

  已经在相转移条件下检查了15种噻唑和许多其他杂芳族化合物（吡啶，噻吩和咪唑）的氢-氘交换。研究了11种季铵盐，铵盐和son盐以及17种溶剂的影响。盐的链长的[我（CH效果2）Ñ ] 4 [省略了图形]溴- （Ñ = 1-5）已审查。报告了七种噻唑的一级动力学（在噻唑中）。本发明的方法提供了一种具体的途径，可用于特定的和更高的氘代（D 90％）噻唑和其他芳族化合物。

  DOI：

  10.1039/p19810001763
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 5-ethylthiazole
  参考文献：
  名称：

  Preparation of thiazoles

  摘要：

  公开号：

  US02263014A1

文献信息

• Ganapathi; Venkataraman, Proceedings - Indian Academy of Sciences, Section A, 1945, # 22, p. 362,376
  作者：Ganapathi、Venkataraman

  DOI：——

  日期：——
• Poite,M.; Metzger,J., Bulletin de la Societe Chimique de France, 1962, p. 2078 - 2085
  作者：Poite,M.、Metzger,J.

  DOI：——

  日期：——
• Analogs of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor
  作者：A. Wissner、M. L. Carroll、K. E. Green、S. S. Kerwar、W. C. Pickett、R. E. Schaub、L. W. Torley、S. Wrenn、C. A. Kohler

  DOI：10.1021/jm00087a023

  日期：1992.5

  A series of aryl phosphoglyceride (3, 19-6 1) and bis-aryl phosphate (67-135) antagonists of platelet activating factor (PAF) were prepared. A group of four bifunctional phosphorus reagents (5a-c and 7) were developed that allowed the preparation of these aryl phosphates in which the position of aromatic substitution can be varied. These compounds were examined for their ability to inhibit PAF-induced platelet aggregation of rabbit platelets. Selected compounds were also evaluated for their ability to displace [H-3]PAF from its receptor on rabbit platelets. These in vitro data were compared to similar data obtained for a number of known PAF antagonists. The compounds were evaluated in vivo, in both the mouse and rabbit, for their ability to prevent death induced by a lethal challenge of PAF. The relationships between the biological activity and the nature, lipophilicity, and position of substituents of the aromatic rings were studied. Compound 105 (CL 184005) has been selected to undergo further development as a potential therapeutic agent for the treatment of septic shock in man.

表征谱图