[4-(2-carbazol-9-yl ethoxy)phenyl]carbamic acid 4-nitrophenyl ester | 1374216-27-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [4-(2-carbazol-9-yl ethoxy)phenyl]carbamic acid 4-nitrophenyl ester
• 英文别名: (4-nitrophenyl) N-[4-(2-carbazol-9-ylethoxy)phenyl]carbamate
• CAS: 1374216-27-9
• 化学式: C₂₇H₂₁N₃O₅
• 分子量: 467.481
• InChiKey: WZGPSWAIQXFDAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  98.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [4-(2-carbazol-9-yl ethoxy)phenyl]carbamic acid 4-nitrophenyl ester 、 乙硫醇钠 以 二氯甲烷 为溶剂， 反应 24.0h， 以70%的产率得到[4-(2-carbazol-9-ylethoxy)phenyl]thiocarbamic acid S-ethyl ester
  参考文献：
  名称：

  Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages

  摘要：

  Series of carbamate and thiocarbamate derivatives were designed and synthesized and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. Several thoicarbamate derivatives revealed promising inhibitory activity. The structure-activity relationship study of these compounds is also reported. Among these compounds, compound 12b was the most potent with 6.5 mu M of IC50. They inhibited NO production through the suppression of iNOS protein and mRNA expression and nuclear translocation of p65. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.03.010
• 作为产物：
  描述：

  9-咔唑乙醇 在 palladium 10% on activated carbon 、 氢气 、 sodium hydride 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 20.0~70.0 ℃ 、101.33 kPa 条件下， 反应 56.0h， 生成 [4-(2-carbazol-9-yl ethoxy)phenyl]carbamic acid 4-nitrophenyl ester
  参考文献：
  名称：

  Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages

  摘要：

  Series of carbamate and thiocarbamate derivatives were designed and synthesized and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. Several thoicarbamate derivatives revealed promising inhibitory activity. The structure-activity relationship study of these compounds is also reported. Among these compounds, compound 12b was the most potent with 6.5 mu M of IC50. They inhibited NO production through the suppression of iNOS protein and mRNA expression and nuclear translocation of p65. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.03.010

文献信息

• Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages
  作者：Guo Hua Jin、Hwa Jin Lee、Hyo Jin Gim、Jae-Ha Ryu、Raok Jeon

  DOI：10.1016/j.bmcl.2012.03.010

  日期：2012.5

  Series of carbamate and thiocarbamate derivatives were designed and synthesized and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. Several thoicarbamate derivatives revealed promising inhibitory activity. The structure-activity relationship study of these compounds is also reported. Among these compounds, compound 12b was the most potent with 6.5 mu M of IC50. They inhibited NO production through the suppression of iNOS protein and mRNA expression and nuclear translocation of p65. (C) 2012 Elsevier Ltd. All rights reserved.