2-(羟基甲氧基)乙酸甲酯 | 109745-70-2

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-(羟基甲氧基)乙酸甲酯
• 英文名称: Methyl hydroxymethoxyacetate
• 英文别名: methyl 2-(hydroxymethoxy)acetate
• CAS: 109745-70-2；19757-97-2
• 化学式: C₄H₈O₄
• 分子量: 120.1
• InChiKey: RNVVYVPDHMKDTL-UHFFFAOYSA-N

物化性质

• 沸点：
  117-120 °C
• 密度：
  1.174±0.06 g/cm3(Predicted)
• 闪点：
  67°C
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(羟基甲氧基)乙酸甲酯 、 (S)-(+)-2-(苯胺甲基)吡咯烷 在 水 作用下， 以 苯 为溶剂， 反应 0.5h， 以there were obtained 1.38 g of 2-carbomethoxy-3-phenyl-1,3-diazabicyclo[3,3,0]octane的产率得到2-methoxycarbonyl-3-phenyl-1,3-diazabicyclo<3.3.0>octane
  参考文献：
  名称：

  Process for preparing .alpha.-hydroxyaldehyde

  摘要：

  一种光学活性或外消旋的α-羟基醛，由通式（2）表示，其中R1代表C6-C14芳基，C1-C10烷基，C3-C10烯基，C2-C10炔基，C7-C14芳基烷基或含有有机部分的官能团的基团，R2代表C1-C10烷基，C2-C10烯基，C2-C10炔基，C7-C14芳基烷基，C6-C14芳基或含有有机部分的官能团的基团，该化合物是制备药物和农药的重要中间体，通过将通式（1）表示的光学活性或外消旋化合物（其中A代表C6-C14芳基或C1-C4烷基或烷氧基或卤素取代的C6-C14芳基，R1如上所定义）与格氏试剂反应，然后水解反应产物制备而成。

  公开号：

  US04383122A1

文献信息

• Process for preparing .alpha.-hydroxyaldehyde
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04383122A1

  公开（公告）日：1983-05-10

  An optically active or racemic .alpha.-hydroxyaldehyde represented by the general formula (2), ##STR1## wherein R.sub.1 represents a C.sub.6 -C.sub.14 aryl group, C.sub.1 -C.sub.10 alkyl group, C.sub.3 -C.sub.10 alkenyl group, C.sub.2 -C.sub.10 alkynyl group, C.sub.7 -C.sub.14 aralkyl group, or a group containing a functional group in the organic portion of said groups and R.sub.2 represents a C.sub.1 -C.sub.10 alkyl group, C.sub.2 -C.sub.10 alkenyl group, C.sub.2 -C.sub.10 alkynyl group, C.sub.7 -C.sub.14 aralkyl group, C.sub.6 -C.sub.14 aryl group, or a group containing a functional group in the organic portion of these groups, which is an important intermediate for preparation of pharmaceuticals and agricultural chemicals, and prepared by allowing an optically active or racemic compound represented by the general formula (1), ##STR2## (wherein A represents a C.sub.6 -C.sub.14 aryl group or a C.sub.1 -C.sub.4 alkyl or alkoxy group- or halogen-substituted C.sub.6 -C.sub.14 aryl group and R.sub.1 is as defined above) to react with a Grignard reagent, and thereafter hydrolyzing the reaction product.

  一种光学活性或外消旋的α-羟基醛，由通式（2）表示，其中R1代表C6-C14芳基，C1-C10烷基，C3-C10烯基，C2-C10炔基，C7-C14芳基烷基或含有有机部分的官能团的基团，R2代表C1-C10烷基，C2-C10烯基，C2-C10炔基，C7-C14芳基烷基，C6-C14芳基或含有有机部分的官能团的基团，该化合物是制备药物和农药的重要中间体，通过将通式（1）表示的光学活性或外消旋化合物（其中A代表C6-C14芳基或C1-C4烷基或烷氧基或卤素取代的C6-C14芳基，R1如上所定义）与格氏试剂反应，然后水解反应产物制备而成。
• Synthesis of 6-hydroxychroman-2-methanol derivatives
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04424389A1

  公开（公告）日：1984-01-03

  A process for producing chroman, a compound of the formula, ##STR1## or an optically active compound thereof wherein R.sub.2, R.sub.3 and R.sub.4 are each a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, which comprises reacting a compound of the formula, ##STR2## or an optically active compound thereof wherein A is an aryl group and R.sub.5 is a C.sub.1 -C.sub.4 alkyl group, with a compound of the formula, ##STR3## wherein R.sub.1 is a C.sub.1 -C.sub.3 alkyl group, X is a halogen atom and R.sub.2, R.sub.3 and R.sub.4 are as defined above, to obtain a compound of the formula, ##STR4## or an optically active compound thereof wherein A, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined above, reacting the resulting compound with methylmagnesium halide and then hydrolyzing to obtain the corresponding 4-aryl substituted 2-hydroxy-2-methylbutanal, or an optically active compound thereof, reducing the resulting compound to obtain a diol, or an optically active compound thereof, and then oxidizing the resulting compound to obtain a compound of the formula, ##STR5## or an optically active compound thereof wherein R.sub.2, R.sub.3 and R.sub.4 are as defined above, followed by reduction. Chromans, the objective compounds of this invention, are an intermediate for the synthesis of tocopherols, particularly .alpha.-tocopherol.

  一种生产香豆素的方法，该化合物的式子为##STR1##或其手性活性化合物，其中R.sub.2，R.sub.3和R.sub.4均为氢原子或C.sub.1-C.sub.4烷基；包括将式子##STR2##或其手性活性化合物与式子##STR3##反应，其中A为芳基且R.sub.5为C.sub.1-C.sub.4烷基，R.sub.1为C.sub.1-C.sub.3烷基，X为卤原子，R.sub.2，R.sub.3和R.sub.4如上定义，以获得式子##STR4##或其手性活性化合物，其中A，R.sub.1，R.sub.2，R.sub.3和R.sub.4如上定义，然后将所得化合物与甲基镁卤反应，然后水解以获得相应的4-芳基取代的2-羟基-2-甲基丁醛，或其手性活性化合物，还原所得化合物以获得二醇，或其手性活性化合物，然后氧化所得化合物以获得式子##STR5##或其手性活性化合物，其中R.sub.2，R.sub.3和R.sub.4如上定义，最后还原。香豆素是本发明的目标化合物，是合成生育酚特别是α-生育酚的中间体。
• .alpha.-Hydroxyaldehyde and a process for preparing the same
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04337346A1

  公开（公告）日：1982-06-29

  An optically active or racemic .alpha.-hydroxyaldehyde represented by the general formula (2), ##STR1## wherein R.sub.1 represents a C.sub.6 -C.sub.14 aryl group, C.sub.1 -C.sub.10 alkyl group, C.sub.3 -C.sub.10 alkenyl group, C.sub.2 -C.sub.10 alkynyl group, C.sub.7 -C.sub.14 aralkyl group, or a group containing a functional group in the organic portion of said groups and R.sub.2 represents a C.sub.1 -C.sub.10 alkyl group, C.sub.2 -C.sub.10 alkenyl group, C.sub.2 -C.sub.10 alkynyl group, C.sub.7-C.sub.14 aralkyl group, C.sub.6 -C.sub.14 aryl group, or a group containing a functional group in the organic portion of these groups, which is an important intermediate for preparation of pharmaceuticals and agricultural chemicals, and prepared by allowing an optically active or racemic compound represented by the general formula (1), ##STR2## (wherein A represents a C.sub.6 -C.sub.14 aryl group or a C.sub.1 -C.sub.4 alkyl or alkoxy group- or halogen-substituted C.sub.6 -C.sub.14 aryl group and R.sub.1 is as defined above) to react with a Grignard reagent, and thereafter hydrolyzing the reaction product.

  一种光学活性或外消旋的α-羟基醛，由通式（2）表示，其中R1代表C6-C14芳基，C1-C10烷基，C3-C10烯基，C2-C10炔基，C7-C14芳基烷基或含有所述基有机部分中的功能基团的基团，R2代表C1-C10烷基，C2-C10烯基，C2-C10炔基，C7-C14芳基烷基，C6-C14芳基或含有这些基有机部分中的功能基团的基团。该化合物是制备药物和农药的重要中间体，通过使通式（1）表示的光学活性或外消旋化合物（其中A表示C6-C14芳基或C1-C4烷基或烷氧基或卤素取代的C6-C14芳基，R1如上所述）与格氏试剂反应，然后水解反应产物制备而成。
• MUKAIYAMA, TERUAKI;SAKITO, YOJI
  作者：MUKAIYAMA, TERUAKI、SAKITO, YOJI

  DOI：——

  日期：——
• SEHNTO, IODZI;SUDZUKAMO, KATAO
  作者：SEHNTO, IODZI、SUDZUKAMO, KATAO

  DOI：——

  日期：——