申请人：Spirogen Limited
公开号：US20030120069A1
公开（公告）日：2003-06-26
Compounds of the formulae Ia and Ib:
1
wherein:
A is CH
2
, or a single bond;
R
2
is selected from: R, OH, OR, CO
2
H, CO
2
R, COH, COR, SO
2
R, CN;
R
6
, R
7
and R
9
are independently selected from H, R, OH, OR, halo, amino, NHR, nitro, Me
3
Sn;
and R
8
is selected from H, R, OH, OR, halo, amino, NHR, nitro, Me
3
Sn, where R is as defined above, or the compound is a dimer with each monomer being the same or different and being of formula Ia or Ib, where the R
8
groups of the monomers form together a bridge having the formula —X—R′—X— linking the monomers, where R′ is an alkylene chain containing from 3 to 12 carbon atoms, which chain may be interrupted by one or more hetero-atoms and/or aromatic rings and may contain one or more carbon-carbon double or triple bonds, and each X is independently selected from O, S, or N;
except that in a compound of formula Ia when A is a single bond, then R
2
is not CH═CH(CONH
2
) or CH═CH(CONMe
2
). Other related compounds are also disclosed.
Ia和Ib的化合物的公式：
其中：
A为CH
2
，或者是一个单键；
R
2
从以下选取：R、OH、OR、CO
2
H、CO
2
R、COH、COR、SO
2
R、CN；
R
6
、R
7
和R
9
独立地从H、R、OH、OR、卤素、氨基、NHR、硝基、Me
3
Sn中选取；
而R
8
从H、R、OH、OR、卤素、氨基、NHR、硝基、Me
3
Sn中选取，其中R如上所定义，或者该化合物是一个二聚体，每个单体相同或不同，且具有Ia或Ib的式，其中单体的R
8
基共同形成具有式—X—R′—X—的桥，连接单体，其中R′是含有3至12个碳原子的烷基链，该链可以被一个或多个杂原子和/或芳香环打断，并且可以含有一个或多个碳-碳双键或三键，每个X独立地从O、S或N中选取；
除了在Ia的化合物中，当A是一个单键时，那么R
2
不是CH═CH(CONH
2
)或CH═CH(CONMe
2
)。还披露了其他相关化合物。
