2-[((4,5-二氢-2-噻唑基)硫代]-1-(3,4-二羟基苯基)乙酮盐酸盐 | 1173023-52-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-[((4,5-二氢-2-噻唑基)硫代]-1-(3,4-二羟基苯基)乙酮盐酸盐
• 英文名称: Retra
• 英文别名: 2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-(3,4-dihydroxyphenyl)ethanone;hydrochloride
• CAS: 1173023-52-3
• 化学式: C11H12ClNO3S2
• 分子量: 305.8
• InChiKey: ZZAVDVMJZKDBIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.54
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• USE OF DIANHYDROGALACTITOL OR ANALOGS AND DERIVATIVES IN COMBINATION WITH VEGF INHIBITORS TO TREAT CANCER
  申请人：DEL MAR PHARMACEUTICALS (BC) LTD.

  公开号：US20200062839A1

  公开（公告）日：2020-02-27

  Methods and compositions employing dianhydrogalactitol or a derivative or analog of dianhydrogalactitol together with a vascular endothelial growth factor (VEGF) inhibitor or other anti-neoplastic agents can be used for treatment of glioma. In particular, methods and compositions according to the invention can decrease the invasiveness of gliomas. Further disclosed are methods of using the compositions for treating a malignancy that has failed a VEGF inhibitor treatment.