3-Ethyl-2-oxaspiro[4.4]nonan-1-one | 65757-11-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 3-Ethyl-2-oxaspiro[4.4]nonan-1-one
• CAS: 65757-11-1
• 化学式: C₁₀H₁₆O₂
• 分子量: 168.23
• InChiKey: CDDCQHGDBLKBQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE
  申请人：Temple University Of The Commonwealth System Of Higher Education

  公开号：EP3738955A1

  公开（公告）日：2020-11-18

  Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

  本发明的药物组合物包括在治疗与 5-羟色胺受体 7 活性失调有关的疾病方面具有疾病调节作用的官能化内酯衍生物。
• 5-hydroxytryptamine receptor 7 activity modulators and their method of use
  申请人：TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US10287274B2

  公开（公告）日：2019-05-14

  Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

  本发明的药物组合物包括在治疗与 5-羟色胺受体 7 活性失调有关的疾病方面具有疾病调节作用的官能化内酯衍生物。
• Modulators of the sigma-2 receptor and their method of use
  申请人：Temple University-Of the Commonwealth System of Higher Education

  公开号：US10961249B2

  公开（公告）日：2021-03-30

  Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity.

  本发明的药物组合物包括在治疗与 sigma-2 受体活性失调有关的疾病时具有疾病调节作用的官能化内酯衍生物。
• NOVEL SIGMA-2 RECEPTOR BINDERS AND THEIR METHOD OF USE
  申请人：Temple University-Of The Commonwealth System of Higher Education

  公开号：US20180221365A1

  公开（公告）日：2018-08-09

  Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity.
• NOVEL MODULATORS OF THE SIGMA-2 RECEPTOR AND THEIR METHOD OF USE
  申请人：Temple University-Of the Commonwealth System of Higher Education

  公开号：US20200039985A1

  公开（公告）日：2020-02-06

  Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity.