1-[(3E)-3-prop-2-enylidene-2H-indol-1-yl]ethanone | 121359-36-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-[(3E)-3-prop-2-enylidene-2H-indol-1-yl]ethanone
• CAS: 121359-36-2
• 化学式: C₁₃H₁₃NO
• 分子量: 199.252
• InChiKey: MAVIRSWBPFUSAE-WDZFZDKYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-碘乙酰苯胺 在 palladium diacetate 、 三苯基膦 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 1-[(3E)-3-prop-2-enylidene-2H-indol-1-yl]ethanone
  参考文献：
  名称：

  Palladium Catalysed Tandem Cyclisation–Anion Capture Processes. Part 4: Organotin(IV) Transfer Agents

  摘要：

  Palladium(0) catalysed cascade mono- and bis-cyclisation-anion capture involving a wide variety of starter species, terminating species and organotin(IV) anion capture reagents are reported leading to a range of bridged, fused and spirocyclic products. The diastereoselectivity of the bis-cyclisation processes is explained in terms of steric effects in the transition states. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00659-1

文献信息

• Regiospecific palladium catalysed tandem cyclisation-anion capture processes. Stereospecific group transfer from organotin reagents.
  作者：Barry Burns、Ronald Grigg、Piniti Ratananukul、Visuvanathar Sridharan、Paul Stevenson、Sukanthini Sukirthalingam、Tanachat Worakun

  DOI：10.1016/s0040-4039(00)80814-x

  日期：1988.1
• Palladium Catalysed Tandem Cyclisation–Anion Capture Processes. Part 4: Organotin(IV) Transfer Agents
  作者：Paul Fretwell、Ronald Grigg、Jose M Sansano、Visuvanathar Sridharan、Sukanthini Sukirthalingam、David Wilson、James Redpath

  DOI：10.1016/s0040-4020(00)00659-1

  日期：2000.9

  Palladium(0) catalysed cascade mono- and bis-cyclisation-anion capture involving a wide variety of starter species, terminating species and organotin(IV) anion capture reagents are reported leading to a range of bridged, fused and spirocyclic products. The diastereoselectivity of the bis-cyclisation processes is explained in terms of steric effects in the transition states. (C) 2000 Elsevier Science Ltd. All rights reserved.