2-phenythiosemicarbazide | 13207-43-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-phenythiosemicarbazide
• 英文别名: 2-phenyl thiosemicarbazide；2-Phenyl-thiosemicarbazid；1-phenyl-hydrazinecarbothioamide；Phenylhydrazinecarbothioamide；1-amino-1-phenylthiourea
• CAS: 13207-43-7
• 化学式: C₇H₉N₃S
• 分子量: 167.235
• InChiKey: UIGWHMHFJHXQQM-UHFFFAOYSA-N

物化性质

• 沸点：
  309.9±25.0 °C(Predicted)
• 密度：
  1.356±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-phenythiosemicarbazide 在 乙醇 作用下， 生成 苯胺基硫脲
  参考文献：
  名称：

  Pellizzari, Gazzetta Chimica Italiana, 1911, vol. 41 II, p. 39

  摘要：

  DOI：
• 作为产物：
  描述：

  2-phenyl-carbazonitrile 在 硫化氢 、 氨 作用下， 生成 2-phenythiosemicarbazide
  参考文献：
  名称：

  2-Phenylselenosemicarbazide and Related Compounds. Dipole Moment and Spectroscopic Measurements on Analogous Ureides, Thioureides, and Selenoureides^1,2

  摘要：

  DOI：

  10.1021/ja01582a029

文献信息

• [EN] INHIBITORS OF MALT1 PROTEASE<br/>[FR] INHIBITEURS DE LA PROTÉASE MALT1
  申请人：HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT GMBH

  公开号：WO2014086478A1

  公开（公告）日：2014-06-12

  The present invention relates to compounds which are inhibitors of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALTl) and to their use in therapy, in particular in the treatment or prevention of a disease or disorder which is treatable by an inhibitor of a paracaspase. The present invention also relates to pharmaceutical compositions containing such compounds.

  本发明涉及作为粘膜相关淋巴组织淋巴瘤易位蛋白1（MALT1）抑制剂的化合物及其在治疗中的应用，尤其是在治疗或预防可通过抑制paracaspase治疗的疾病或失调中的应用。本发明还涉及含有该化合物的药物组合物。
• PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS
  申请人：Incyte Corporation

  公开号：US20170275290A1

  公开（公告）日：2017-09-28

  This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

  这个应用涉及到Formula I的化合物： 或其药用可接受的盐，这些化合物是TAM激酶的抑制剂，可用于治疗癌症等疾病。
• [EN] PYRIDAZINE DERIVATIVES AND THEIR USE AS CYCLOOXYGENASE-2 INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIDAZINE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE CYCLOOXYGENASE-2
  申请人：ABIDA

  公开号：WO2021124344A1

  公开（公告）日：2021-06-24

  The present invention relates to compound of formula I and II, or its pharmaceutically acceptable salt; wherein R is selected from the group consisting of -H, -F, -Cl, -Br, -I, -NO2, -CH3, or -C2H5; R1 is selected from the group consisting of –H, or -CH3; R2 is selected from the group consisting of –H or a group of Formula III; wherein R3 and R4 are selected from the group consisting of –H, -CH3, -C2H5, -F, -Cl, -Br, -I, or -NO2; the dotted line in compound of formula I and II indicates that the ring structure may contain a double bond.

  本发明涉及公式I和II的化合物，或其药学上可接受的盐；其中R选自-H、-F、-Cl、-Br、-I、-NO2、-CH3或-C2H5组成的群体；R1选自-H或-CH3组成的群体；R2选自-H或Formula III中的一组；其中R3和R4选自-H、-CH3、-C2H5、-F、-Cl、-Br、-I或-NO2组成的群体；在公式I和II的化合物中，虚线表示环结构可能含有双键。
• Synthesis, anticancer activity and mechanism of action of new thiazole derivatives
  作者：Temístocles Italo de Santana、Miria de Oliveira Barbosa、Paulo André Teixeira de Moraes Gomes、Anne Cecília Nascimento da Cruz、Teresinha Gonçalves da Silva、Ana Cristina Lima Leite

  DOI：10.1016/j.ejmech.2017.12.040

  日期：2018.1

  antiproliferative. The present work reports the synthesis of 22 new substances belonging to two classes of compounds: thiosemicarbazones and thiazoles, with the purpose of developing new drugs that present high specificity for tumor cells and low toxicity to the organism. A cytotoxic screening was performed to evaluate the performance of the new derivatives in five tumor cell lines. Eight compounds were shown to

  噻唑衍生物被认为具有多种生物活性，如抗寄生虫，抗真菌，抗微生物和抗增殖。本工作报道了属于两类化合物的22种新物质的合成：硫代半脲和噻唑，目的是开发对肿瘤细胞具有高特异性且对生物体毒性低的新药物。进行了细胞毒性筛选，以评估新衍生物在五种肿瘤细胞系中的性能。至少在三种肿瘤细胞系中，显示出八种化合物很有前途。这些化合物的IC 50在72小时内确定，并评估了活性结构比。然后评估最佳化合物对PBMC的影响和溶血活性测定。化合物1d 被认为是最有希望的测试样本，并评估了其对细胞周期，DNA片段化和线粒体去极化的影响。
• [EN] USE OF DYNAMIC MIXTURES FOR A CONTROLLED RELEASE OF FRAGRANCES<br/>[FR] UTILISATION DE MELANGES DYNAMIQUES POUR LIBERATION CONTROLEE DE FRAGRANCES
  申请人：FIRMENICH & CIE

  公开号：WO2006016248A1

  公开（公告）日：2006-02-16

  The present invention relates to a delivery system in the form of a dynamic mixture obtained by reacting together, in the presence of water, at least one hydrazine derivative with at least one perfuming, flavoring, insect repellent or attractant, bactericide and/or fungicide aldehyde or ketone. The invention's mixture is capable of releasing in a controlled and prolonged manner said aldehyde or ketone in the surrounding environment. Furthermore, the present invention concerns also the use of said dynamic mixtures as perfuming ingredients as well as the perfuming compositions or perfumed articles comprising the invention's mixtures.

  本发明涉及一种交互反应得到的动态混合物形式的递送系统，所述动态混合物是通过在水的存在下，将至少一种肼衍生物与至少一种香料、调味剂、驱虫剂或诱引剂、杀菌剂和/或杀菌醛或酮一起反应而获得的。本发明的混合物能够在周围环境中以受控和持久的方式释放所述的醛或酮。此外，本发明还涉及将所述动态混合物用作香料成分，以及包含本发明混合物的香水组合物或香水制品的用途。