N-lauroyl-N-methyl-alanine | 111389-50-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-lauroyl-N-methyl-alanine
• 英文别名: N-Lauroyl-N-methyl-alanin；2-[Dodecanoyl(methyl)amino]propanoic acid
• CAS: 111389-50-5
• 化学式: C₁₆H₃₁NO₃
• 分子量: 285.427
• InChiKey: LBWWHVIOWSHHLG-UHFFFAOYSA-N

物化性质

• 熔点：
  65-65.5 °C
• 沸点：
  421.5±28.0 °C(Predicted)
• 密度：
  0.977±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  月桂酰氯 、 N-Methylalanin 在 sodium hydroxide 作用下， 生成 N-lauroyl-N-methyl-alanine
  参考文献：
  名称：

  The Preparation of Long Chain N-Acylamino Acids

  摘要：

  DOI：

  10.1021/ja01582a049

文献信息

• SKIN EXTERNAL PREPARATIONS AND COSMETICS
  申请人：Aoki Hirobumi

  公开号：US20100280111A1

  公开（公告）日：2010-11-04

  An object of the present invention is to provide skin external preparations and cosmetics which contain a branched acyl carnitine and have excellent formulation stability. A skin external preparation of the present invention includes a carnitine derivative represented by the following Formula (1) and/or a carnitine derivative salt represented by the following Formula (2), and an amphoteric surfactant. In Formula (1), R 1 and R 2 are each independently a C1-18 optionally branched, saturated or unsaturated aliphatic hydrocarbon group. In Formula (2), R 1 and R 2 are the same as in Formula (1), X − is a specific anion and Y + is a specific cation.

  本发明的一个目的是提供含有支链酰基肉碱并具有优异配方稳定性的皮肤外用制剂和化妆品。本发明的皮肤外用制剂包括以下式（1）所表示的肉碱衍生物和/或以下式（2）所表示的肉碱衍生物盐，以及一种两性表面活性剂。在式（1）中，R1和R2分别独立地是C1-18的可选支链、饱和或不饱和脂肪烃基。在式（2）中，R1和R2与式（1）中相同，X−是特定的阴离子，Y+是特定的阳离子。
• SKIN AGENT FOR EXTERNAL USE AND COSMETIC AGENT INCLUDING UBIQUINONE DERIVATIVE OR SALT THEREOF AND METHOD USING THE SAME
  申请人：Aoki Hirobumi

  公开号：US20100074879A1

  公开（公告）日：2010-03-25

  A skin agent for external use and a cosmetic agent are provided, by transdermal administration of which expected actions and effects of ubiquinone derivatives, salts thereof, ubiquinones and ubiquinols are effectively obtained. The skin agent for external use includes a ubiquinone derivative or a salt thereof as an active ingredient. The ubiquinone derivative is represented by the formula (1): wherein R 1 and R 2 are each a hydrogen atom or a phosphoric group, at least one of R 1 and R 2 is a phosphoric group, and n is an integer in the range of 1 to 9.

  提供了一种外用皮肤剂和化妆品剂，通过经皮给药，可以有效地获得辅酶Q衍生物、其盐、辅酶Q和辅酶QH的预期作用和效果。外用皮肤剂包括辅酶Q衍生物或其盐作为活性成分。辅酶Q衍生物由式（1）表示：其中R1和R2分别是氢原子或磷酸基团，R1和R2中至少有一个是磷酸基团，n是1到9范围内的整数。
• [EN] TOPICAL SLIMMING PREPARATION AND A COSMETIC CONTAINING A CARNITINE DERIVATIVE<br/>[FR] PRÉPARATION EXTERNE POUR L'AMINCISSEMENT DE LA PEAU ET PRODUIT COSMÉTIQUE CONTENANT CETTE PRÉPARATION
  申请人：SHOWA DENKO KK

  公开号：WO2005115326A1

  公开（公告）日：2005-12-08

  The invention provides a slimming skin external preparation and a cosmetic that contain a carnitine derivative having excellent skin affinity and percutaneous absorption properties and capable of enhancing the fat metabolism, and that can treat, reduce or prevent the obesity by functioning as a lipolytic agent to enhance the fat metabolism of general or local subcutaneous fat tissues. The slimming skin external preparation contains a particular carnitine derivative such as a cylcarnitines and alcohol carnitine esters and preferably other slimming and skin-care ingredients.

  本发明提供了一种减肥皮肤外用制剂和化妆品，其中包含一种肉碱衍生物，具有优异的皮肤亲和性和经皮吸收性能，能够增强脂肪代谢，并且能够作为脂肪分解剂，促进一般或局部皮下脂肪组织的脂肪代谢，从而治疗、减少或预防肥胖。该减肥皮肤外用制剂包含特定的肉碱衍生物，如环肉碱和醇肉碱酯，并且最好还包含其他减肥和护肤成分。
• EMULSION PREPARATION FOR EXTERNAL APPLICATION TO SKIN AND COSMETIC PREPARATION
  申请人：Showa Denko K.K.

  公开号：EP2238970A1

  公开（公告）日：2010-10-13

  An object of the present invention is to provide emulsified skin external preparations and cosmetics which contain a branched acyl carnitine and have excellent emulsion stability. An emulsified skin external preparation according to the present invention includes 0.01 to 10% by mass of a carnitine derivative represented by the following Formula (1) and/or a carnitine derivative salt represented by the following Formula (2), and 0.01 to 20% by mass of a nonionic surfactant. In Formula (1), R1 and R2 are each independently a C1-18 optionally branched, saturated or unsaturated aliphatic hydrocarbon group. In Formula (2), R1 and R2 are the same as in Formula (1), X- is a specific anion and Y+ is a specific cation.

  本发明的一个目的是提供含有支链酰基肉碱且具有优异乳化稳定性的乳化皮肤外用制剂和化妆品。根据本发明的乳化皮肤外用制剂包括下列式（1）所表示的肉碱衍生物和/或下列式（2）所表示的肉碱衍生物盐，以及非离子表面活性剂，其质量百分含量分别为0.01至10%和0.01至20%。在式（1）中，R1和R2各自独立地是C1-18的可选支链、饱和或不饱和脂肪烃基。在式（2）中，R1和R2与式（1）中相同，X-是特定阴离子，Y+是特定阳离子。
• [EN] HYDROXYCITRIC ACID DERIVATIVES AND SKIN EXTERNAL PREPARATIONS CONTAINING THE SAME<br/>[FR] DERIVES D'ACIDE HYDROXYCITRIQUE ET PREPARATIONS EXTERNES POUR LA PEAU LES CONTENANT
  申请人：SHOWA DENKO KK

  公开号：WO2006033476A1

  公开（公告）日：2006-03-30

  Hydroxycitric acid derivatives and salts thereof are provided which are useful as active ingredients of skin external preparations and cosmetics. Also provided are processes for production of the hydroxycitric acid derivatives, and skin external preparations and cosmetics containing the hydroxycitric acid derivatives. Specific hydroxycitric acid derivatives or salts thereof are produced wherein at least one of the hydroxyl groups of hydroxycitric acid, or least one of the hydroxyl groups and at least one carboxyl group of hydroxycitric acid are modified to linkage moieties breakable by biological enzyme reaction. The hydroxycitric acid derivatives or salts thereof are added in skin external preparations and cosmetics.

  提供了羟基柠檬酸衍生物及其盐，可用作皮肤外用制剂和化妆品的活性成分。还提供了生产羟基柠檬酸衍生物的方法，以及含有羟基柠檬酸衍生物的皮肤外用制剂和化妆品。生产特定羟基柠檬酸衍生物或其盐，其中羟基柠檬酸的至少一个羟基或至少一个羟基和至少一个羧基被修饰为可被生物酶反应断裂的连接基团。将羟基柠檬酸衍生物或其盐添加到皮肤外用制剂和化妆品中。