3-methoxy-4-heptanon | 64549-29-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methoxy-4-heptanon
• 英文别名: 3-Methoxy-4-heptanone；3-methoxyheptan-4-one
• CAS: 64549-29-7
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: PPVIGLHWNQLEQO-UHFFFAOYSA-N

物化性质

• 沸点：
  134 °C(Press: 746 Torr)
• 密度：
  0.876±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-methoxy-4-heptanon 、 异丙基溴化镁 生成 4-isopropyl-3-methoxy-heptan-4-ol
  参考文献：
  名称：

  通过乙二醇和相关化合物的阳极裂解合成羰基化合物

  摘要：

  DOI：

  10.1016/s0040-4039(01)83310-4
• 作为产物：
  描述：

  2-methoxybutanenitrile 、 丙基溴化镁 在 乙醚 作用下， 生成 3-methoxy-4-heptanon
  参考文献：
  名称：

  Synthesis of 1-Methoxypropyl Ketones

  摘要：

  DOI：

  10.1021/ja01174a060

文献信息

• New general synthesis of α-alkoxyketones via α′-alkylation, α-alkylation and α,α′-dialkylation of α-alkoxyketimines
  作者：Filip Colpaert、Sven Mangelinckx、Maria Teresa Rocchetti、Norbert De Kimpe

  DOI：10.1039/c0ob00662a

  日期：——

  important intermediates in organic synthesis and flavor compounds in food chemistry, were synthesized by deprotonation of N-(1-alkoxy-2-propylidene)isopropylamine, prepared by condensation of the corresponding α-alkoxyacetone with isopropylamine, and subsequent reaction of the corresponding 1-azaallylic anions with alkyl halides to afford α′-alkylated, α-alkylated and α,α′-dialkylated ketimines. Hydrolysis

  α-甲氧基和α-乙氧基酮是食品化学中有机合成和香料化合物的重要中间体，是通过将相应的α-烷氧基丙酮与N-（1-烷氧基-2-亚丙基）异丙胺脱质子化反应制得的异丙胺然后，使相应的1-氮杂烯丙基阴离子与烷基卤反应，得到α'-烷基化，α-烷基化和α，α'-二烷基化的酮亚胺。亚氨基官能团的水解产生所需的取代的α-烷氧基酮。α-，α'-和α，α'-（二）烷基化化合物的比例取决于所用碱的量和烷基化试剂的性质。
• Compounds and oligomeric compounds comprising novel nucleobases
  申请人：——

  公开号：US20040033973A1

  公开（公告）日：2004-02-19

  The present invention relates to nucleoside compositions comprising novel nucleobases and oligomeric compounds comprising at least one such nucleoside. These oligomeric compounds typically have enhanced binding affinity properties compared to oligomeric compounds without the modification. The oligomeric compounds are useful, for example, for investigative and therapeutic purposes.

  本发明涉及包含新型核碱基的核苷酸组合物以及包含至少一种此类核苷酸的寡聚合物化合物。这些寡聚合物化合物通常具有比没有这种修饰的寡聚合物化合物更强的结合亲和性能。这些寡聚合物化合物可用于调查和治疗等用途。
• NUCLEOBASE HETEROCYCLIC COMBINATORIALIZATION
  申请人：——

  公开号：US20020009748A1

  公开（公告）日：2002-01-24

  Mixtures of chemical compounds are provided having antibacterial and other utility. The mixtures are formed, preferably in solution phase, from the reaction of a purine or pyrimiding heterocyclic scaffold with a set of related chemical substituients, optionally through employment of a tether moiety. Libraries formed in accordance with the invention have utility per se and are articles of commerce. They can be used to screen for pesticides, drugs and other biologically active compounds.

  提供具有抗菌和其他用途的化合物混合物。这些混合物通常在溶液相中形成，由嘌呤或嘧啶杂环支架与一组相关的化学取代物反应而成，可选地通过使用连接基团。根据本发明形成的文库本身具有实用性并且是商业产品。它们可用于筛选杀虫剂、药物和其他生物活性化合物。
• Methods of enhancing renal uptake of oligonucleotides
  申请人：——

  公开号：US20040009938A1

  公开（公告）日：2004-01-15

  2′-O-Modified ribosyl nucleosides and modified methods containing such nucleosidic monomers are disclosed. Methods are disclosed that have increased binding affinity as shown by molecular modeling experiments. Methods are also disclosed for enhancing the renal uptake of oligomeric compounds as shown using a two-step HRP imunohistochemistry assay. The 2′-O-modified nucleosides of the invention include ring structures that position the sugar moiety of the nucleosides preferentially in 3′ endo geometries.

  本发明揭示了包含2'-O-修饰核糖核苷和含有这种核苷单体的修饰方法。通过分子建模实验证明，所述方法具有增强的结合亲和力。还揭示了一种方法，用于通过使用两步酶联免疫组织化学检测法显示增强寡聚化合物的肾脏摄取。本发明的2'-O-修饰核苷包括环结构，将核苷的糖基团体优先定位在3'-内部几何构型中。
• AMINOOXY-MODIFIED NUCLEOSIDIC COMPOUNDS AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
  申请人：——

  公开号：US20030088079A1

  公开（公告）日：2003-05-08

  Nucleosidic monomers and oligomeric compounds prepared therefrom are provided which have increased nuclease resistance, substituent groups (such as 2′-aminooxy groups) for increasing binding affinity to complementary strand, and regions of 2′-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H. Such oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics.

  提供具有增强核酸酶抵抗性的核苷酸单体和由此制备的寡聚化合物，这些化合物具有取代基团（例如2'-氨氧基基团）以增加与互补链的结合亲和力，并具有激活RNase H的2'-脱氧-赤霉糖核苷酸区域。这些寡聚化合物可用于诊断和其他研究目的，用于调节生物体中蛋白质的表达，并用于对易受寡核苷酸治疗的其他疾病进行诊断、检测和治疗。