9-Ethyl-9H-pyrido[2,3-b]indole-3-carboxylic acid ethyl ester | 189182-83-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9-Ethyl-9H-pyrido[2,3-b]indole-3-carboxylic acid ethyl ester
• 英文别名: Ethyl 9-ethyl-9H-pyrido[2,3-B]indole-3-carboxylate；ethyl 9-ethylpyrido[2,3-b]indole-3-carboxylate
• CAS: 189182-83-0
• 化学式: C₁₆H₁₆N₂O₂
• 分子量: 268.315
• InChiKey: WLJPDGAXGDESRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-amino-1-ethyl-3-thioformylindole 、 丙炔酸乙酯 110.0 ℃ 、2.0 kPa 条件下， 反应 48.0h， 以60%的产率得到9-Ethyl-9H-pyrido[2,3-b]indole-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  Reaction of heteroaromatic o-aminothioaldehydes with alkynes: a novel entry to b-fused pyridines

  摘要：

  o-Aminothioaldehydes derived from benzo[b]furan, benzo[b]thiophene, indole and furan rings smoothly react with mono- and disubstituted electron deficient alkynes to give b-fused dihydropyridines which can be converted to corresponding pyridines upon heating under vacuum. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00274-8

文献信息

• CN117263933
  申请人：——

  公开号：——

  公开（公告）日：——
• Reaction of heteroaromatic o-aminothioaldehydes with alkynes: a novel entry to b-fused pyridines
  作者：Alessandro Degl'Innocenti、Maria Funicello、Patrizia Scafato、Piero Spagnolo

  DOI：10.1016/s0040-4039(97)00274-8

  日期：1997.3

  o-Aminothioaldehydes derived from benzo[b]furan, benzo[b]thiophene, indole and furan rings smoothly react with mono- and disubstituted electron deficient alkynes to give b-fused dihydropyridines which can be converted to corresponding pyridines upon heating under vacuum. (C) 1997 Published by Elsevier Science Ltd.