4-(1,1-Dimethylethyl)-2,5-dimethyloxazole | 26028-51-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(1,1-Dimethylethyl)-2,5-dimethyloxazole
• 英文别名: 4-Tert-butyl-2,5-dimethyl-1,3-oxazole
• CAS: 26028-51-3
• 化学式: C₉H₁₅NO
• 分子量: 153.224
• InChiKey: LQGYVLRCLBDMEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3--2-(ethanoyloxy)-4,4-dimethyl-2-pentene 625.0 ℃ 、133.32 Pa 条件下， 以93%的产率得到4-(1,1-Dimethylethyl)-2,5-dimethyloxazole
  参考文献：
  名称：

  Synthesis of oxazoles from O-trimethylsilyl acyltrimethylsilane cyanohydrins

  摘要：

  Sequential addition of organolithium reagents and acyl chlorides (or anhydrides) to O-trimethylsilyl acyltrimethylsilane cyanohydrins affords beta-(acyloxy)-N,N-bis(trimethylsilyl) enamines which cyclize to substituted oxazoles under thermolysis or treatment with trimethylsilyl trifluoromethanesulfonate. Oxazoles were prepared containing alkyl and phenyl substituents at C-5, alkyl, alkenyl, and phenyl substituents at C-4, and alkyl, alkenyl, phenyl, and functionalized substituents at C-2.

  DOI：

  10.1021/jo00038a020

文献信息

• BACE INHIBITORS
  申请人：Eli Lilly and Company

  公开号：US20140371212A1

  公开（公告）日：2014-12-18

  The present invention provides a compound of Formula III: wherein A is: and Z, R 1 , R 2 , R 3 , and R 4 are as defined herein, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种III式化合物：其中A是：以及Z、R1、R2、R3和R4如本文所定义，或其药学上可接受的盐。
• STING AGONIST COMPOUNDS AND METHODS OF USE
  申请人：Mersana Therapeutics, Inc.

  公开号：US20210032269A1

  公开（公告）日：2021-02-04

  The present disclosure relates to STING (Stimulator of Interferon Genes) agonist compounds, methods of making the compounds and their methods of use.

  本公开涉及STING（干扰素基因刺激剂）激动剂化合物，制备这些化合物的方法以及它们的使用方法。
• [EN] TRICYCLIC COMPOUNDS AND THEIR USE<br/>[FR] COMPOSÉS TRICYCLIQUES ET LEUR UTILISATION
  申请人：HUTCHISON MEDIPHARMA LTD

  公开号：WO2020244637A1

  公开（公告）日：2020-12-10

  Tricyclic compounds and their use are provided. More specifically, tricyclic compounds, pharmaceutical compositions containing them, methods for preparing them, and their use in therapy are also provided.

  提供了三环化合物及其用途。更具体地，还提供了三环化合物、含有它们的药物组合物、制备它们的方法，以及它们在治疗中的用途。
• FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS
  申请人：Gilead Sciences, Inc.

  公开号：US20150175560A1

  公开（公告）日：2015-06-25

  The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein X, Y, Z, R 2 , R 3 , R 4 , p and q are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

  本公开涉及一类钠通道抑制剂化合物及其在治疗各种疾病状态中的应用，包括心血管疾病和糖尿病。具体实施例中，该化合物的结构由式I给出：其中X、Y、Z、R2、R3、R4、p和q如本文所述，以及制备和使用该化合物的方法以及含有该化合物的药物组合物。
• PYRIDONE COMPOUNDS AND AGRICULTURAL AND HORTICULTURAL FUNGICIDES CONTAINING THE SAME AS ACTIVE INGREDIENTS
  申请人：MITSUI CHEMICALS AGRO, INC.

  公开号：US20200045968A1

  公开（公告）日：2020-02-13

  Pyridine compounds of Formula (1) are provided: wherein R1, R2, X, Y and Het are defined. The pyridine compounds can be used to treat or prevent plant diseases.

  提供了化合物的化学式（1）：其中R1、R2、X、Y和Het均已定义。这些吡啶化合物可用于治疗或预防植物疾病。